Heart Arrest (Cardiac Arrest)

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7337 relevant articles (366 outcomes, 872 trials/studies) found for this Disease

Description: Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.

Also Known As:

Cardiac Arrest; Asystole; Arrest, Cardiac; Arrest, Cardiopulmonary; Arrest, Heart; Asystoles; Cardiopulmonary Arrest

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 18509

Heart Diseases: 12346

Heart Arrest: 7337

Cardiac Sudden Death: 1525

Related Diseases

1.	Ventricular Fibrillation
2.	Hypothermia
3.	Heart Arrest (Cardiac Arrest)
4.	Ventricular Tachycardia
5.	Wounds and Injuries (Trauma)

Experts

1.	Tang, Wanchun: 14 articles (10/2008 - 01/2002)
2.	Callaway, Clifton W: 14 articles (08/2008 - 07/2002)
3.	Sterz, Fritz: 13 articles (06/2008 - 04/2002)
4.	Weil, Max Harry: 11 articles (10/2008 - 01/2002)
5.	Lurie, Keith G: 11 articles (07/2008 - 04/2002)
6.	Nichol, Graham: 10 articles (08/2008 - 10/2003)
7.	Böttiger, Bernd W: 10 articles (07/2008 - 03/2002)
8.	Berg, Robert A: 10 articles (04/2008 - 02/2002)
9.	Kochanek, Patrick M: 10 articles (02/2008 - 01/2002)
10.	Wenzel, V: 10 articles (05/2005 - 09/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Heart Arrest:

1.	Epinephrine (Adrenaline)FDA LinkGeneric 01/01/1990 - "A prospective, randomized, blinded study was conducted to evaluate the efficacy of standard compared with high-dose epinephrine in cardiac arrest in dogs" 07/01/1996 - "OBJECTIVE: To compare the efficacy of high-dose epinephrine (HDE) with standard-dose epinephrine (SDE) in the management of cardiac arrest in adults in the prehospital setting" 06/01/1995 - "To compare the efficacy of high-dose epinephrine (HDE) and standard-dose epinephrine (SDE) for out-of-hospital treatment of pediatric cardiopulmonary arrest (CPA)" 10/08/1992 - "High-dose epinephrine was not found to improve survival or neurologic outcomes in adult victims of cardiac arrest." 05/01/1986 - "In both series, pure respiratory arrest had a significantly better outcome than cardiopulmonary arrest, and predictors of nonsurvival were a duration of arrest greater than 15 min and the administration of more than one iv bolus of epinephrine" Order ALL the reference details at left...
2.	Vasopressins (Vasopressin)IBA 10/01/2005 - "Although there is a suggestion that vasopressin may be effective in treatment of asystole, the evidence for this arises from a subgroup analysis that should be viewed as hypothesis generating" 07/01/2006 - "STUDY OBJECTIVE: The use of vasopressin in patients with cardiac arrest presenting with specific rhythms is controversial" 10/01/2005 - "STUDY SELECTION AND DATA EXTRACTION: Prospective, randomized, controlled trials that evaluated efficacy or safety endpoints of vasopressin in the management of cardiac arrest were included" 01/10/2005 - "The objective of this study was to determine the effectiveness of vasopressin in the treatment of cardiac arrest" 11/01/2003 - "We systematically reviewed randomized trials comparing vasopressin to control treatment in the management of cardiac arrest in humans and animals" Order ALL the reference details at left...
3.	Amiodarone (Amiodarona)FDA LinkGeneric 10/01/1998 - "The ARREST trial, a randomized trial comparing IV amiodarone to placebo, found a significant improvement in the proportion of patients surviving to the emergency department following out-of-hospital cardiac arrest in amiodarone-treated patients" 09/01/2001 - "The endpoint of the only cardiac arrest study available shows improved survival when amiodarone is combined with other drugs over placebo until the patient gets to the emergency department, but is not a comparison with other current drugs nor had any effect on long-term survival or functioning neurologic status" 03/01/2006 - "These results should provoke other institutions to question whether amiodarone has improved survival of cardiac arrest under the conditions prevailing in their hospitals" 02/01/2005 - "In the CASCADE trial, carried out in survivors of cardiac arrest, the prescription of amiodarone in patients with IAD significantly reduced the number of defibrillation shocks" 05/01/2004 - "CONCLUSIONS: The present study suggests that amiodarone can be administered undiluted without unmanageable haemodynamical side-effects in the treatment of out-of-hospital cardiac arrest" Order ALL the reference details at left...
4.	OxygenIBA 02/01/1992 - "We conclude that using the pharyngeal lumen of the PtL for continuous delivery of oxygen combined with external chest compressions can provide a safe and effective mode of oxygenation and ventilation during cardiac arrest." 07/01/2000 - "The purpose of this investigation was to test the hypothesis that a head down position may prevent aspiration during chest compressions alone and whether oxygenation can be improved by simply insufflation of oral oxygen 10 min after cardiac arrest" 08/01/2008 - "AIM: This controlled, prospective, randomized porcine study tests the hypothesis that high-dose hyperbaric oxygen (HDHBO2) compared with normobaric oxygen (NBO2) or standard-dose hyperbaric oxygen (SDHBO2), improves return of sustained spontaneous circulation (ROSC) after a normothermic, normobaric, 25-min, non-intervened-upon cardiopulmonary arrest" 06/01/2006 - "Moreover, these findings indicate the need for clinical trials comparing the effects of different ventilatory oxygen levels on neurologic outcome after cardiac arrest." 04/01/2004 - "In the present study seven adult, non-traumatic, out-of-hospital cardiac arrest patients were intubated and mechanically ventilated at 12 min(-1) with 100% oxygen and a tidal volume of 700 ml (10 +/- 2 ml kg(-1))" Order ALL the reference details at left...
5.	Adenosine FDA LinkGeneric 08/01/2000 - "Safety and efficacy of high-dose adenosine-induced asystole during endovascular AAA repair." 08/01/1996 - "TECHNIQUE: In the anesthetized patient, trial doses of intravenous adenosine are delivered until a > or = 20-second period of asystole is recorded" 09/01/2008 - "Asystole duration in relationship to the dosage of adenosine, safety, and side effect profiles was investigated" 12/01/2007 - "With its nosecone removed, a 32-x36-mm Zenith aortic cuff was delivered to the ascending aorta via the left CCA and positioned under transient cardiac arrest initiated with intravenous adenosine" 11/01/2006 - "CONCLUSIONS: In this swine model, adenosine A(1) receptor antagonism accelerated the natural decay in the ECG VF waveform during the circulatory phase of cardiac arrest" Order ALL the reference details at left...
6.	CalciumIBA 01/01/2003 - "The aim of this study was to examine the myocardial histohematic barriers during the rehabilitation period after a cardiac arrest for 10 min. The electron histochemical analysis was applied to evaluate the permeability of histohematic barriers, to assess their ultrastructure and calcium localization" 08/01/1991 - "Recently, however, the use of calcium during cardiac arrest has come into dispute, as there are no controlled clinical trials supporting a favourable haemodynamic effect" 01/01/1985 - "Neurological recovery after cardiac arrest: clinical feasibility trial of calcium blockers." 04/01/1984 - "Additional studies are needed to define the role of calcium and its antagonists in the treatment of asystole and PIVR." 08/01/1983 - "A prospective, controlled, blind study was done to test the effect of a calcium entry blocker on the neurologic integrity of dogs after cardiopulmonary arrest" Order ALL the reference details at left...
7.	Lactic Acid FDA LinkGeneric 11/01/2007 - "Effective lactate clearance is associated with improved outcome in post-cardiac arrest patients." 07/01/2006 - "This retrospective study showed the limitation of PCPS therapy for patients with an episode of cardiac arrest who did not show improvement in their APACHE II score, urine output, serum lactate levels, and catecholamine dose received within 72 hours after PCPS induction" 02/01/2007 - "CONCLUSIONS: This study showed that high serum lactate, high P(a-et)CO(2) and high V(dA)/V(t) during early ROSC in cardiac arrest patients suggest high hospital mortality" 05/01/1988 - "Further studies are needed to evaluate the effects of lowered lactic acid on survival and neurological outcome following cardiac arrest." 11/01/2007 - "CONCLUSIONS: Early, effective lactate clearance is associated with decreased early and overall in-hospital mortality in post-cardiac arrest patients" Order ALL the reference details at left...
8.	Cardioplegic SolutionsIBA 04/01/2005 - "This procedure has traditionally been "invasive", requiring a micro-surgery technique, institution of extra-corporeal circulation, as well as temporary cardiac arrest with a cardioplegic solution" 02/01/2003 - "Cardiac arrest was induced with 4 degrees C St. Thomas cardioplegic solution, at which point the heart was made globally ischemic by withholding perfusion for 45 min followed by 40 min reperfusion" 01/01/2001 - "Cardiac arrest was induced in situ by aortic cross clamping or by additional coronary perfusion with various cardioplegic solutions" 10/01/1996 - "A blood cardioplegic solution at 38 degrees C and 70 mm Hg pressure was infused to maintain asystole during the initial 7 to 10 minutes of reperfusion in all groups" 06/01/1996 - "Hyperkalemic cardioplegic solutions produce cardiac arrest during open heart surgery by depolarizing the sarcolemma" Order ALL the reference details at left...
9.	Adenosine Triphosphate (ATP)IBA 05/01/1982 - "Compared with results in a group undergoing simple ischemic arrest, significantly greater myocardial adenosine triphosphate concentrations were present at 90 and 120 minutes of cardiac arrest in the coronary artery washout group" 04/01/1997 - "The effects of these stimuli on myocardial ATP, ventricular contractility, and the time to cessation of electromechanical function (asystole) during the sustained ischemic period were then examined" 02/01/1997 - "At the end of cardiac arrest, group 1 had significantly higher adenosine triphosphate (19.4 +/- 1.1 mumol/g dry weight and 15.05 +/- 1.8 mumol/g dry weight, respectively) (P = 0.05) and significantly lesser fall in energy charge than group 2 (0.02 +/- 0.01 and 0.05 +/- 0.02, respectively) (P = 0.05)" 11/01/1995 - "These results suggest that ATP incorporated into ICDs is useful in survivors of cardiac arrest and may significantly reduce the number of shocks that these patients would otherwise receive" 11/01/1994 - "Bolus infusion ATP caused < or = 6.4-s asystole that was self-limited" Order ALL the reference details at left...
10.	Atropine (Hyoscyamine)FDA LinkGeneric 09/01/1984 - "Atropine in asystole: human studies." 08/01/2007 - "The patient was given 0.5 mg of atropine, and asystole began and ended" 11/01/2006 - "Atropine was given but cardiac asystole occurred" 02/07/2006 - "When sinus cardiac arrest for 2 s or complete atrio-ventricular block occurred programmed bilateral vagal nerves stimulation (VNS) was performed with the frequency of 12.5 Hz, impulse duration of 0.5 ms, and voltage of 5-8 V. Atropine 0.04 mg/kg was dripped intravenously" 09/01/2005 - "Prompt intravenous atropine failed to regain normal sinus rhythm, and cardiac arrest ensued" Order ALL the reference details at left...

Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR) 09/01/2006 - "OBJECTIVE: Witnessed collapse and bystander CPR are the variables most frequently associated with good outcome from out-of-hospital cardiac arrest (OOHCA)" 03/01/2007 - "Clinical factors suggesting a good outcome are witnessed cardiac arrest in a previously healthy child with immediate initiation of effective CPR and good brain perfusion and function as evidence by substantial bodily movement during CPR" 10/01/2006 - "High quality cardiopulmonary resuscitation (CPR) in the pre-hospital setting has been associated with improved survival rates during cardiopulmonary arrest (CPA)" 06/01/2006 - "CONCLUSION: ITPR-CPR significantly improved hemodynamics, vital organ perfusion pressures and common carotid blood flow compared to STD-CPR in a porcine model of prolonged cardiac arrest and basic life support" 03/01/2005 - "There were no survivors among patients with time since collapse greater than 10 min. Among patients with time since collapse of 4 min or longer, survival was significantly higher with the performance of bystander CPR; there was no survival advantage to bystander CPR among patients with time since collapse less than 4 min. CONCLUSIONS: The performance of bystander CPR prior to defibrillation by EMS personnel is associated with improved survival among patients with time since collapse longer than 4 min but not less than 4 min. These data are consistent with the three-phase model of cardiac arrest." Order ALL the reference details at left...
2.	Resuscitation 04/01/2002 - "STUDY OBJECTIVE: The quality of life in long-term survivors of out-of-hospital cardiac arrest may be a good outcome measure after resuscitation" 09/01/1984 - "The medical antishock trouser (MAST) has been advocated as potentially beneficial in the resuscitation of patients in cardiac arrest" 09/29/2006 - "CONCLUSION: An immediate resuscitation plan consisting of an integrated programme of early defibrillation is feasible and seems to achieve an improved prognosis for patients who have sustained an in-hospital cardiac arrest." 12/01/1999 - "BACKGROUND: The involvement of general practitioners in community based resuscitation of out-of-hospital cardiac arrest has been found to be effective in improving survival rates" 09/01/1981 - "The relative efficacy of these drugs in aiding resuscitation from cardiopulmonary arrest is unknown" Order ALL the reference details at left...
3.	Defibrillators (Defibrillator) 01/01/2006 - "CONCLUSION: Automated external defibrillators deployed in readily accessible, well-marked areas, are really very effective in assisting patients with cardiac arrest" 10/17/2002 - "CONCLUSIONS: Automated external defibrillators deployed in readily accessible, well-marked public areas in Chicago airports were used effectively to assist patients with cardiac arrest" 09/26/2001 - "CONTEXT: Installation of automated external defibrillators (AEDs) on passenger aircraft has been shown to improve survival of cardiac arrest in that setting, but the cost-effectiveness of such measures has not been proven" 01/01/2007 - "SUMMARY: Automated external defibrillators appear to be cost-effective in locations with high incidences of cardiac arrest." 02/05/2004 - "INTERPRETATION: Application of the strategy of public-access defibrillators will not result in significantly improved survival from cardiac arrest in Norway." Order ALL the reference details at left...
4.	Cardiopulmonary Bypass (Heart-Lung Bypass) 06/01/1997 - "Endovascular cardiopulmonary bypass using the endoaortic clamp was effective in achieving cardiac arrest and myocardial protection to allow internal mammary artery to coronary artery anastomosis in a still and bloodless field" 05/01/2003 - "OBJECTIVE: To investigate the myocardial protective effects of beating heart versus heart arrest in goats undergoing open heart surgery with cardiopulmonary bypass (CPB)" 07/01/1978 - "This study describes ultrastructural, enzymatic, and functional assessments of the efficacy of three infusates (Bretschneider, Kirsch, and St. Thomas' Hospital) in a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest" 07/01/2008 - "Utstein style study of cardiopulmonary bypass after cardiac arrest." 05/01/2005 - "In a local, retrospective, observational study, 535 patients had a CABG done with the aid of cardiopulmonary bypass and cardiac arrest" Order ALL the reference details at left...
5.	Decompression 06/01/2003 - "During cardiac arrest, active decompression of the chest and impedance of inspiratory airflow during the recoil of the chest work by increasing negative intrathoracic pressure and, hence, increase refilling of the ventricles and increase cardiac preload, with improvement in survival" 06/01/2008 - "Safety, feasibility, and hemodynamic and blood flow effects of active compression-decompression of thorax and abdomen in patients with cardiac arrest." 12/01/2007 - "We report our experience using the Lund University Cardiac Arrest System (LUCAS, Jolife, Lund, Sweden) which is a gas-driven sternal compression device that incorporates a suction cup for active decompression" 04/01/2005 - "In the emergency department, 28 min after cardiac arrest, spontaneous circulation returned briefly but the patient rapidly became asystolic and mechanical compression-decompression was again applied" 04/01/2005 - "A 62-year-old man suffered out-of-hospital cardiac arrest and was treated with mechanical compression-decompression during transport to the hospital" Order ALL the reference details at left...

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