|1.||Asthma (Bronchial Asthma)
|5.||Perennial Allergic Rhinitis
|1.||Meltzer, Eli O: 26 articles (09/2015 - 06/2002)|
|2.||Valenta, Rudolf: 26 articles (05/2015 - 01/2002)|
|3.||Okubo, Kimihiro: 24 articles (01/2015 - 02/2005)|
|4.||Durham, Stephen R: 16 articles (04/2015 - 01/2002)|
|5.||Ebner, Christof: 16 articles (01/2015 - 01/2002)|
|6.||Valenta, R: 16 articles (02/2014 - 01/2000)|
|7.||Horak, Friedrich: 15 articles (01/2015 - 06/2002)|
|8.||Wahn, Ulrich: 14 articles (06/2014 - 02/2002)|
|9.||Vieths, Stefan: 14 articles (03/2014 - 11/2002)|
|10.||Ratner, Paul H: 13 articles (09/2015 - 05/2003)|
|1.||Loratadine (Alavert)FDA Link
09/01/1994 - "Prophylactic loratadine therapy was effective in suppressing symptoms of seasonal allergic rhinitis and providing patients with symptom-free days throughout the pollen season."
12/01/1991 - "We conclude that loratadine and intranasal BDP were effective in the treatment of seasonal allergic rhinitis, but the spectrum of individual symptoms controlled was different for the 2 drugs."
12/01/1990 - "Thus loratadine is an effective and safe antihistamine when given once daily for the symptomatic relief of seasonal allergic rhinitis."
08/01/1989 - "Loratadine appears to be a simple, effective and safe therapy for seasonal allergic rhinitis."
06/01/1987 - "Safety and efficacy of loratadine (Sch-29851): a new non-sedating antihistamine in seasonal allergic rhinitis."
01/01/1984 - "Eighty patients with hay fever took part in a double-blind study to compare the efficacy of two doses of terfenadine, namely 60 mg b.d., the standard recommended dose, and 120 mg b.d. "
12/01/1989 - "Terfenadine, 120 mg once daily, is as effective as the currently approved dosage of 60 mg twice daily in the treatment of seasonal allergic rhinitis, and terfenadine, 120 mg once daily, has the added convenience of allowing the patient once a day dosing."
10/27/1988 - "The cumulative results indicate that the nonsedative antihistamine terfenadine, given orally at a dosage of 60 mg twice daily, is effective in the treatment of seasonal allergic rhinitis in both adults and children. "
04/01/1988 - "It is concluded that terfenadine is a safe and effective non-sedating antihistamine in the maintenance therapy of seasonal allergic pollinosis and that tolerance is not noted during continued administration."
09/01/1990 - "terfenadine, given to avoid withdrawals from the trial because of hay fever symptoms. "
|3.||Cetirizine (Zyrtec)FDA LinkGeneric
03/01/1990 - "Cetirizine at a single dose of 10 mg displayed equal efficacy in controlling hayfever symptoms but, in common with other studies, had a significantly greater incidence of drowsiness (p = 0.046)."
04/01/1997 - "Once-daily cetirizine effective in the treatment of seasonal allergic rhinitis in children aged 6 to 11 years: a randomized, double-blind, placebo-controlled study."
07/01/2015 - "FPNS and cetirizine were equally effective in treating fall seasonal allergic rhinitis during a 2-week head-to-head treatment investigation. "
05/01/1998 - "Cetirizine is well tolerated and effective in reducing symptoms of seasonal allergic rhinitis in patients undergoing controlled pollen challenge."
11/01/2002 - "The objective of this study was to evaluate the health-related quality of life (HRQL) effects, safety and efficacy of cetirizine in the treatment of seasonal allergic rhinitis, and impact on self-reported work/school-related productivity and activity impairment (WPAI). "
|4.||fluticasone (Cutivate)FDA LinkGeneric
06/01/1993 - "Fluticasone propionate aqueous nasal spray, a new potent corticosteroid, is effective when given once or twice daily for seasonal allergic rhinitis. "
10/01/1994 - "Intranasal fluticasone propionate, 200 micrograms or 100 micrograms once daily, was significantly more effective than placebo in the treatment of seasonal allergic rhinitis in children. "
08/01/1996 - "Fluticasone propionate aqueous nasal spray, a new topical corticosteroid, has been proved to be an effective treatment for seasonal allergic rhinitis. "
10/01/1993 - "In children as young as 4 years, 100 micrograms of fluticasone propionate aqueous nasal spray given once daily is as effective as 200 micrograms given once daily, the usual adult dose for the treatment of seasonal allergic rhinitis. "
10/01/1993 - "Fluticasone propionate aqueous nasal spray, a new topical corticosteroid preparation, is effective when given as 200 micrograms once daily in patients (> 12 years of age) with seasonal allergic rhinitis. "
|5.||Immunoglobulin E (IgE)IBA
01/01/1998 - "In conclusion, the LMD may be a better "gold standard" for the detection of Japanese cedar pollen-specific IgE than the skin test, and the combination of the nasal provocation test and the LMD is a better diagnostic tool for the detection of Japanese cedar pollen-induced seasonal allergic rhinitis than the combination of the nasal provocation test and the skin test or the CAP."
05/01/2003 - "Factors affecting spontaneous remission include sex, age at the time, serum IgE titer to JCP and age at first onset of JC pollinosis. "
06/01/1999 - "CCDs must be taken into account when evaluating the clinical relevance of positive results in in vitro specific IgE assays, at least in the diagnosis of patients with pollen allergy. "
09/01/2014 - "Seventy-eight 60- to 70-year-old patients with SAR and a confirmed grass pollen allergy according to skin-prick tests, nasal provocation, and measurement of serum IgE were included in the study. "
07/01/2014 - "In this study, we investigated the changes of IgE binding components to tree and weed pollens in pollinosis patients who showed a paradoxical increase of serum sIgE level during pollen-SIT. "
|6.||azelastine (Optivar)FDA LinkGeneric
04/01/1994 - "In this 2-day trial in patients with seasonal allergic rhinitis, we evaluated the onset of action, duration of effect, and safety and efficacy of azelastine nasal solution (Astelin N.S.) in an outdoor, highly allergenic environment. "
04/01/1994 - "Azelastine nasal spray, administered either once or twice daily, was effective in treating the symptoms of seasonal allergic rhinitis and demonstrated a rapid onset of action with a duration of response lasting 12 to 24 hours."
01/01/2013 - "Azelastine has been shown to be effective against seasonal allergic rhinitis (SAR). "
06/01/1999 - "Three multicenter, randomized, double-blind studies were conducted to determine whether patients with moderate-to-severe symptoms of seasonal allergic rhinitis who had responded inadequately to monotherapy with either an oral antihistamine or an intranasal corticosteroid, and who were candidates for combination therapy with both an oral antihistamine and an intranasal corticosteroid, could be effectively treated with azelastine nasal spray monotherapy. "
03/01/1987 - "In addition, azelastine has been shown to have an effect on the upper airways by effective symptom relief in patients with seasonal allergic rhinitis; furthermore, azelastine affords protection against exercise and allergen provocation."
|7.||fexofenadine (Allegra)FDA LinkGeneric
10/01/1999 - "Once-daily fexofenadine HCl, 120 or 180 mg, significantly improved patient-reported quality of life and reduced performance impairment in work and daily activities due to seasonal allergic rhinitis symptoms compared with placebo."
11/01/1997 - "Fexofenadine HCl is both effective and safe for the treatment of ragweed seasonal allergic rhinitis. "
01/01/2011 - "Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials."
06/01/2004 - "To evaluate the safety and efficacy of fexofenadine in children with seasonal allergic rhinitis, data were pooled from three, double-blind, randomized, placebo-controlled, parallel-group, 2-week trials in children (6-11 year) with seasonal allergic rhinitis. "
06/01/2004 - "Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis--a pooled analysis of three studies."
|8.||Histamine Antagonists (Antihistamines)IBA
09/01/2005 - "Although antihistamines are highly effective in alleviating many symptoms associated with seasonal allergic rhinitis (SAR), relief from nasal congestion is variable. "
12/01/2010 - "These findings suggest that preseasonal prophylactic treatment with antihistamines is more effective than on-seasonal administration to patients with pollinosis in reducing nasal symptoms during the peak pollen period by suppressing H1R gene expression in the nasal mucosa."
12/01/2008 - "Recently, prophylactic treatment with antihistamines in patients with pollinosis was reported to be more effective when started before the pollen season. "
07/01/1986 - "There is some danger in using them for efficacy trials because antihistamines are only partially effective treatment for hay fever and the challenge administered could easily overcome the degree of protection. "
08/01/2005 - "Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines."
|9.||montelukast (Singulair)FDA Link
12/01/2006 - "Montelukast treatment provided significant improvement in symptoms and peripheral eosinophil counts of school-age children with seasonal allergic rhinitis; however, it did not show a significant effect on eNO levels."
03/01/2004 - "Montelukast significantly improved daytime nasal symptoms score in patients with seasonal allergic rhinitis, and the effect was greater in patients exposed to higher pollen levels."
09/01/2008 - "Both montelukast 5 mg and 10 mg doses show clinically meaningful efficacy for the treatment of patients with seasonal allergic rhinitis and the safety profiles of those are comparable to that of the placebo."
11/01/2005 - "Montelukast effectively treats the nighttime impact of seasonal allergic rhinitis."
01/01/2005 - "Montelukast has shown efficacy for seasonal allergic rhinitis (SAR); however, onset of action for SAR has not been presented. "
|10.||Beclomethasone (Beclometasone)FDA Link
04/01/1976 - "It is concluded that 400 mug beclomethasone dipropionate a day is a safe and very effective treatment of nasal hay fever symptoms in children."
09/01/1996 - "This paper reviews the results of three clinical reports which show that BDP-ds given once a day is more effective than placebo and as effective as regular-strength beclomethasone dipropionate given twice daily in reducing the nasal symptoms of seasonal allergic rhinitis. "
06/01/1987 - "In conclusion, this study shows that one-dose beclomethasone dipropionate of 400 micrograms is effective in the treatment of seasonal allergic rhinitis."
06/01/1983 - "In conclusion this study showed that two-dose beclomethasone dipropionate with a daily dose of 400 micrograms is effective in the treatment of seasonal allergic rhinitis."
11/01/1995 - "This study assessed the onset of action, level of relief, and efficacy of beclomethasone nasal spray in patients with seasonal allergic rhinitis. "
04/01/2009 - "The clinical efficacy of immunotherapy, either by high dose sublingual-swallow therapy (SLIT) or subcutaneous immunotherapy (SCIT), has been demonstrated in patients with pollinosis but few studies have been carried out analysing differences in these treatments in terms of an improvement of clinical and allergic phlogosis parameters. "
05/01/2004 - "This study was performed to determine clinical efficacy of high dose sublingual swallow immunotherapy (SLIT) by a double-blind placebo-controlled study in children with grass pollen allergy using high dose allergen extracts. "
01/01/2007 - "This review has shown that specific allergen injection immunotherapy in suitably selected patients with seasonal allergic rhinitis results in a significant reduction in symptom scores and medication use. "
11/01/2007 - "Sublingual immunotherapy (SLIT) is accepted as a safe and effective route for the treatment of grass pollen allergy, but clarification of its clinical and biological efficacy requires more study. "
07/01/2001 - "A hybrid peptide comprising 7 T-cell determinants has the potential for inducing T-cell proliferative responses that is superior to the potential of a mixture of the T-cell determinants and comparable with that of Cry j 1 and Cry j 2. The hybrid peptide will be of use in specific immunotherapy against Japanese cedar pollinosis."
11/01/1988 - "Delayed onset of inflammatory nodules following hay fever desensitization injections."
06/01/1962 - "XXI. A study of 29,770 patient-years of symptoms of ragweed pollinosis and 4400 patient-years of injections."
12/01/2013 - "We have previously demonstrated that a majority of hay fever patients are treated with depot-steroid injections in violation of the guidelines. "
11/01/2012 - "Systemic steroid injections are still widely used to treat pollen allergy. "
04/01/2002 - "Thirty-five patients with severe rhinoconjunctivitis (hay fever) to birch pollen were allocated to double-blinded clustered IT with a depot birch pollen extract (Betula verrucosa) or placebo injections. "
|3.||Drug Therapy (Chemotherapy)
11/01/2004 - "[Evaluation of quality of life (QOL) and efficacy of drug therapy on nasal symptoms and QOL disturbances in the patients with Japanese Cedar Pollinosis during the season of 2003 in Kyushu and Okinawa districts]."
08/02/2003 - "To assess the efficacy of enzyme potentiated desensitisation in the treatment of severe summer hay fever poorly controlled by pharmacotherapy. "
06/01/2009 - "The pharmacotherapy is a main treatment tool for pollinosis, and the surgical treatment is not acknowledged to the treatment of pollinosis internationally. "
12/01/2008 - "Although prescribed drugs directly affect patient outcome, the variation in physicians' attitudes towards drug therapy for cedar pollinosis has not been quantitatively assessed. "
07/01/2008 - "Allergen immunotherapy can deliver improvements in hayfever symptoms over and above that which can be achieved by pharmacotherapy. "
09/01/1982 - "In a double-blind, controlled, crossover study involving 47 subjects documented with seasonal allergic rhinitis, repeated intranasal administration of 4% sodium cromoglycate solution was associated with significant reduction in symptoms and decrease in consumption of antihistaminic drugs. "
03/01/1992 - "A 4-week, double-blind, parallel group study compared the safety and efficacy of once-a-day intranasal administration of triamcinolone acetonide (Nasacort) versus placebo in 304 patients (155 adult and 149 adolescent) with seasonal allergic rhinitis. "
03/01/1992 - "Efficacy of once-a-day intranasal administration of triamcinolone acetonide in patients with seasonal allergic rhinitis."
08/01/1977 - "Intranasal administration of a 4% solution of cromolyn sodium for the treatment of ragweed hay fever was tested in an 8-week double-blind matched-pair study involving 66 patients. "
04/01/1977 - "This study indicates that intranasal administration of flunisolide in adult patients is both efficacious and safe in the treatment of seasonal allergic rhinitis."
|5.||Phototherapy (Light Therapy)
12/02/2004 - "As there is a good correlation between SPT and the nasal symptoms in patients with hay fever these data suggest that phototherapy with mUV/VIS light might be an effective and safe treatment modality for immediate type hypersensibility reactions in the skin and nasal mucosa."
07/01/2009 - "Pollen challenge study of a phototherapy device for reducing the symptoms of hay fever."
10/01/2013 - "It has been suggested that intranasal phototherapy represents an alternative choice in the treatment of seasonal allergic rhinitis (SAR). "
03/01/2011 - "We recently showed that intranasal phototherapy represents an efficient therapeutic modality for the treatment of patients with seasonal allergic rhinitis (SAR). "
04/01/2012 - "Re: Endonasal phototherapy for the treatment of allergic rhinitis/hay fever."