|1.||Tuberous Sclerosis (Bourneville's Disease)
|1.||Shields, Carol L: 12 articles (02/2015 - 05/2003)|
|2.||Shields, Jerry A: 10 articles (02/2015 - 05/2003)|
|3.||Meyer, Carsten H: 5 articles (01/2015 - 11/2005)|
|4.||Kerrigan, John F: 4 articles (02/2015 - 01/2009)|
|5.||Marr, Brian P: 4 articles (01/2015 - 05/2003)|
|6.||Ng, Yu-Tze: 4 articles (07/2013 - 01/2010)|
|7.||Requena, Luis: 4 articles (04/2012 - 02/2006)|
|8.||Kwiatkowski, David J: 4 articles (01/2012 - 08/2005)|
|9.||Moss, Joel: 4 articles (01/2011 - 12/2005)|
|10.||Peter, Silvia: 4 articles (03/2007 - 11/2005)|
05/01/2007 - "Double combined pigment epithelial and retinal hamartomas in a single eye: an optical coherence tomographic study."
04/01/2001 - "Apart from the higher prevalence of flat retinal hamartomas, the findings of this study compare closely with previous large clinic based series of TSC patients. "
07/01/1999 - "Subsequent pathologic study of an enucleated globe was diagnostic of a retinal hamartoma. "
11/01/2015 - "[A retinal hamartoma]."
05/01/2015 - "Spectral-Domain Optical Coherence Tomography of Presumed Solitary Circumscribed Retinal Astrocytic Proliferation Versus Astrocytic Hamartoma."
01/01/2009 - "Plasmin-assisted vitrectomy and membrane peeling in this child with bilateral combined hamartoma resulted in a marked improvement in the clinical and topographical appearance in both eyes and significantly improved visual function. "
01/01/2009 - "Plasmin-assisted vitrectomy for bilateral combined hamartoma of the retina and retinal pigment epithelium: histopathology, immunohistochemistry, and optical coherence tomography."
06/01/2009 - "To determine the surgical outcomes of epiretinal membranes associated with combined hamartoma of the retina and retinal pigment epithelium after pars plana vitrectomy and membrane peeling with or without assistance of autologous plasmin enzyme. "
06/01/2009 - "In the pediatric population, pars plana vitrectomy with membrane peeling with or without the use of autologous plasmin enzyme for epiretinal membrane associated with combined hamartomas of the retina and retinal pigment epithelium can result in improved retinal architecture and visual acuity. "
|3.||Gonadotropin-Releasing Hormone (GnRH)FDA Link
05/04/1984 - "Immunocytochemical studies of the tissue demonstrated luteinizing hormone-releasing hormone (LHRH) granules in the perikaryon of neurons and axons in the hamartoma and axons connecting the hamartoma to the tuber cinereum. "
12/01/2015 - "After the clinical and radiological findings, they started treatment with GnRH analogues and a regression of the puberty signs without progression in the hamartomas size was observed. "
04/01/2010 - "In both patients, the hamartomas were partially removed, by γ-knife and surgical operation in the first case and surgically in the second, and a gonadotropin releasing hormone (GnRH) analogue was prescribed. "
12/01/1999 - "The detection of LHRH-containing neurons in some hamartomas has led to the concept that hamartomas advance puberty because they contain an ectopic LHRH pulse generator. "
03/01/1999 - "The gonadotropin releasing hormone (GnRH) secreting hypothalamic hamartoma (HH) is a congenital malformation consisting of a heterotopic mass of nervous tissue that contains GnRH neurosecretory neurons attached to the tuber cinereum or the floor of the third ventricle. "
|4.||Fluorescein (Funduscein)FDA LinkGeneric
04/01/2014 - "Fluorescein angiography and optical coherence tomography findings were compatible with a congenital simple hamartoma of the retinal pigment epithelium. "
02/01/2013 - "Fluorescein angiography (FA) revealed a combined hamartoma of the retina and retinal pigment epithelium (CHRRPE). "
01/01/2013 - "retinal pigment epithelium hamartoma, fluorescein angiography, optical coherence tomography."
05/01/2009 - "Fundus examination and fluorescein angiography findings were consistent with combined hamartoma of the retina and retinal pigment epithelium. "
05/01/2005 - "Fundus examination, fluorescein angiography, ultrasonography, and OCT were done on two cases of simple RPE hamartoma. "
|5.||Proliferating Cell Nuclear Antigen (PCNA)IBA
06/01/2007 - "In this paper we describe the data which improved our knowledge of the disease: 1) nosologically, cerebral cavernomas belong to the group of cerebral vascular hamartomas which can be associated between themselves ("mixed" lesions); 2) hemodynamically, the annual risk of hemorrhage increases after a first bleeding and in deep located lesions (brainstem); 3) association between cavernomas and developmental venous anomalies may be observed; the later on must be left in place at operation; 4) immunocytochemical studies (PCNA) show that cavernomas should be considered more as a benign vascular tumor than as a malformation; 5) familial forms (20%) are characterized by multiple locations and "de novo" lesions; 6) better understanding of the natural history of cavernomas, which is a dynamic lesion, leads to broader surgical indications (no alternative treatment)."
12/01/1996 - "In one patient immunohistochemical analysis with anti-PCNA (proliferative cell nuclear antigen) antibody was useful in distinguishing leiomyomatous hamartoma from benign metastatic leiomyoma."
03/01/2004 - "Proton MR spectroscopy of the hypothalamic hamartoma was performed for 19 patients and compared with the metabolite profile of the thalamus in 10 normal children and the frontal lobe in 10 normal adults. "
04/01/1995 - "Proton MR spectroscopy might prove useful in the diagnosis of hamartomas."
01/01/2002 - "Gelastic seizure with hypothalamic hamartoma: proton magnetic resonance spectrometry and ictal electroencephalographic findings in a 4-year-old girl."
01/01/2000 - "A parietal hamartoma of a three-month-old boy with tuberous sclerosis was studied with magnetic resonance (MR) imaging, and proton MR spectroscopy. "
04/01/1995 - "Proton MR spectroscopy in a possible enhancing hamartoma in a patient with neurofibromatosis type 1."
|7.||Indocyanine Green (Cardio-Green)FDA LinkGeneric
01/01/2013 - "The optical coherence tomography, fluorescein angiography and indocyanine green angiography results confirmed the diagnosis of retinal pigment epithelium hamartoma. "
01/01/2001 - "Recurrent vitreous hemorrhages due to combined pigment epithelial and retinal hamartoma: natural course and indocyanine green angiographic findings."
12/01/2003 - "As small astrocytic hamartomas can sometimes be missed during routine ophthalmoscopy in patients with tuberous sclerosis, fluorescein and/-or indocyanine green angiography maybe more helpful in identifying such small astrocytomas. "
01/01/2013 - "A 60-year-old man with presumed retinal pigment epithelial hamartoma underwent complete ophthalmologic examination, including fluorescein angiography, indocyanine green angiography, enhanced depth imaging OCT, and SS-OCT. "
11/01/2005 - "To describe fundus autofluorescence (AF), fluorescein angiography (FA) and indocyanine green angiography (ICGA) in different types of retinal astrocytic hamartomas in tuberous sclerosis (Morbus Bourneville-Pringle). "
|8.||N-acetylaspartate (N-acetyl aspartate)IBA
06/01/2003 - "On short-TE proton MR spectra, the N-acetylaspartate concentration in the hamartoma was lower than that in the thalamus but similar to that in the amygdala. "
10/01/1998 - "Five patients were studied and the relative intensity of N-acetylaspartate to creatine (NAA/Cr) was determined for both temporal lobes as well as for the hamartoma. "
01/01/2002 - "Proton magnetic resonance spectrometry of the hypothalamic hamartoma revealed a significant reduction of the N-acetylaspartate/serum creatinine ratio. "
07/16/2000 - "The relative intensity of N-acetylaspartate to creatine (NAA/Cr) and NAA/choline (Ch) were not significantly different from normal control subjects for either temporal lobes, whereas the ratio NAA/Ch was decreased and the ratio NAA/Cr was highly increased in the hamartoma. "
01/01/1995 - "Hamartomas showed N-acetyl aspartate/creatine, creatine/choline, and N-acetyl aspartate/choline ratios similar to those of healthy volunteers. "
|9.||Amyloid (Amyloid Fibrils)IBA
07/01/2006 - "No amyloid deposition, no immature epithelial tubules as in hamartomas, and no normal lung structure as in osseous metaplasia were seen. "
07/01/2006 - "Tumors with osseous elements can be found, such as hamartoma and amyloid tumor, and reactive lesions such as osseous metaplasia. "
10/01/2006 - "Nine tumors were proven benign: hamartoma (4), cystic lymphangioma (1), primary amyloid (1), lipoma (1). "
04/01/2015 - "The final gold standard diagnosis was cancer [non-small cell lung cancer, metastatic, carcinoid, carcinoma in situ (24)], benign disease [sarcoid, amyloid, hamartoma, and chondroid tumor (4)], and benign/nonspecific inflammation (14). "
08/01/2006 - "The section devoted to selected pseudotumoral entities considered representatives of the hamartoma group (neural fibrolipomatous hamartoma, ectopic hamartomatous thymoma, rudimentary meningocele), metabolic diseases (amyloid tumor, nephrogenic fibrosing dermopathy, tophaceous pseudogout, pseudoinfiltrative parathyromatosis), stromal tissue reactions to trauma (fibroosseous pseudotumors of digits) and infections (bacillary angiomatosis), and normal organs (glomus coccygeum). "
|10.||glucuronyl glucosamine glycan sulfate (Vessel)IBA
04/01/2015 - "Angiomyomatous hamartoma in an inguinal lymph node with proliferating pericytes/smooth muscle cells, plexiform vessel tangles, and ectopic calcification."
05/01/2009 - "Complete resection of the mass after second surgery resulted in remission of seizures and histopathology revealed hamartoma with hemangiomatous vessel proliferation. "
11/01/2013 - "Subclavian vein aneurysm secondary to a benign vessel wall hamartoma."
01/01/2015 - "A splenectomy was performed and a histologic examination of the splenectomy specimen revealed the presence of multiple hamartomas. "
01/01/2015 - "It is usually asymptomatic but large hamartomas may present with symptoms such as hemopoetic disorders, which resolve after splenectomy. "
01/01/2012 - "Here we report a case of total laparoscopic splenectomy for a bulky splenic hamartoma in a young male patient."
01/01/2012 - "Laparoscopic splenectomy for splenic hamartoma: a case report."
04/27/2010 - "Here we report the third case of splenic hamartoma managed by laparoscopic splenectomy. "
09/01/2009 - "To validate the safety and efficacy of magnetic resonance imaging (MRI)-guided stereotactic radiofrequency thermocoagulation (SRT) for epileptogenic hypothalamic hamartoma (HH), we evaluated surgical outcomes and revised the MRI classification. "
01/01/2013 - "A case of tracheal hamartoma resected with loop electrocautery."
08/01/2007 - "After magnetic resonance imaging-guided targeting, radiofrequency thermocoagulation of the boundary between the hamartoma and normal hypothalamus was performed to achieve disconnection effects. "
08/01/2007 - "A total of five patients with hypothalamic hamartoma were treated by stereotactic thermocoagulation at our hospital during the period October 1997 through February 2004. "
01/01/2006 - "We are presenting a case of endobronchial hamartoma successfully treated with bronchoscopic electrocautery without a need for surgical removal."
02/01/2010 - "In this interventional retrospective case series study, five patients with combined hamartomas of the retina and retinal pigment epithelium received vitrectomy and epiretinal component peeling. "
12/01/2002 - "Visual improvement after pars plana vitrectomy and membrane peeling for vitreoretinal traction associated with combined hamartoma of the retina and retinal pigment epithelium."
02/01/2002 - "Visual improvement after pars plana vitrectomy and membrane peeling for vitreoretinal traction associated with combined hamartoma of the retina and retinal pigment epithelium."
12/01/1984 - "The authors report an unusual case with vitreous hemorrhage due to a vascular hamartoma of the optic nerve-head and treated by pars plana vitrectomy. "
04/01/2007 - "Pars Plana vitrectomy and epiretinal membrane peeling for vitreoretinal traction associated with combined hamartoma of the retina and retinal pigment epithelium (CHRRPE)."
|4.||Drug Therapy (Chemotherapy)
10/01/2004 - "Clarification of the molecular and structural changes involved in skin hamartomas may unravel targets for pharmacotherapy. "
02/01/2008 - "This ictal fluorodeoxyglucose-positron emission tomography is the second reported study verifying that the main source of the epileptic activity inducing gelastic seizures originates from the hypothalamic hamartoma itself; therefore, a complementary fluorodeoxyglucose-positron emission tomography study should be considered in any patient presenting with intractable gelastic seizures, especially in those associated with hypothalamic hamartoma, in order to localize the region of epileptiform activity amenable to surgical resection if intensive drug therapy fails."
01/01/2013 - "Surprisingly, the combined chemotherapy for metastatic sarcoma resulted in almost complete resolution of the hamartoma in the liver. "
01/01/2013 - "Regression of mesenchymal hamartoma of the liver with sarcoma chemotherapy."
05/01/2012 - "The ability to monitor structural changes over time in astrocytic hamartomas using SD-OCT may be beneficial for monitoring the success of systemic chemotherapy in the treatment of various tuberous sclerosis tumors."
03/01/1987 - "We report our experience in treating 15 children using local steroid injections to accelerate regression of such vascular hamartomas. "
11/01/1984 - "We treated six boys, aged 1-6 yr, with true precocious puberty due to hypothalamic hamartoma for 6-24 months with daily sc injections of LRHa. "
07/01/2010 - "Six months after 3 monthly intravitreal ranibizumab injections, FA and OCT revealed the CNV closure and absence of intraretinal and subretinal fluid on the foveal border of the retinal astrocytic hamartoma. "
07/01/2010 - "To report on a patient with retinal astrocytic hamartoma, who developed a choroidal neovascularization (CNV), effectively treated by intravitreal ranibizumab injections. "
01/01/2013 - "Combined bevacizumab and triamcinolone acetonide injections for macular edema in a patient with astrocytic hamartomas and tuberous sclerosis."