H-Y Antigen

A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.

Also Known As:

Networked: 108 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fry, Terry J: 3 articles (01/2014 - 04/2009)
2.	Walsh, Meghaan P: 2 articles (01/2013 - 04/2009)
3.	Manjili, Masoud H: 2 articles (04/2011 - 03/2011)
4.	Lattime, Edmund C: 2 articles (10/2003 - 05/2003)
5.	Yang, Arvin S: 2 articles (10/2003 - 05/2003)
6.	Birattari, Federica: 1 article (03/2021)
7.	Brighenti, Tommaso: 1 article (03/2021)
8.	Fasolo, Adriano: 1 article (03/2021)
9.	Franch, Antonella: 1 article (03/2021)
10.	Frigo, Anna Chiara: 1 article (03/2021)

Related Diseases

1.	46,XY Gonadal Dysgenesis (Swyer Syndrome) 04/15/1977 - "In the present article, we report positive results in the first case of 46,XY pure gonadal dysgenesis (Swyer's syndrome) to be typed for H-Y antigen. " 04/01/1988 - "[46,XY gonadal dysgenesis without H-Y antigen--a case report]." 04/01/1986 - "These findings suggest a relation between the tumorization potentiality of the gonadal remnants and the H-Y antigen levels in 46,XY pure gonadal dysgenesis." 07/01/1981 - "Six patients with pure nonmosaic 46,XY gonadal dysgenesis (XY GD) and histocompatibility H-Y antigen titers in the normal male range (H-Y+) are presented. " 01/01/1980 - "H-Y antigen in 46,XY gonadal dysgenesis."
2.	Graves Disease (Basedow Disease) 01/03/1983 - "The H gene theory is superior to the linkage disequilibrium theory in that it accounts for all the known genetic features of Graves' disease, including the female sex preponderance, which is ascribed to the effect of clonal deletions imposed by the H-Y antigen."
3.	Gonadal Dysgenesis (Gonadal Agenesis) 01/01/1981 - "These observations of genetic heterogeneity must be considered when interpreting studies in which individuals with XY gonadal dysgenesis may or may not show H-Y antigen." 06/01/1984 - "Absence of H-Y antigen in a case of sporadic pure gonadal dysgenesis." 01/01/1984 - "The authors describe a case they have personally seen of pure gonadal dysgenesis with caryotype 46 XY (Swyers' syndrome) in which they found absence of HY antigen. " 08/01/1983 - "Thus it appears that, in the X linked form, XY gonadal dysgenesis may be caused by a point deletion or mutation of a gene on the X chromosome, which controls the gonad specific receptor for the H-Y antigen. " 08/01/1983 - "The titres of H-Y antigen in three girls with XY gonadal dysgenesis were in the male control range. "
4.	Neoplasms (Cancer) 04/01/1986 - "After resection of the tumors, H-Y antigen level became intermediate. " 04/01/1986 - "Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. " 04/01/1986 - "Three patients, without gonadal tumor, had female H-Y antigen. " 07/01/1985 - "Since these tumors lack the Y chromosome (required for production of the H-Y antigen that is presumably obligatory for embryonic male sexual differentiation), identifiable male sex organ structures should not be found in the tumor. " 01/01/2014 - "To test this hypothesis, we utilized the clinically relevant male-specific antigen HY and studied the fate of adoptively transferred, HY-CD8(+) T cells (HY-CD8) against a HY-expressing epithelial tumor (MB49) and pre-B cell leukemia (HY-E2APBX ALL) in BMT recipients. "
5.	Ovotesticular Disorders of Sex Development 05/01/1987 - "When the study is done HY antigen is always increased in patients with true hermaphroditism and sometimes slightly increased in their mothers who are phenotypically normal." 01/01/1980 - "H-Y antigen expression in a case of XX true hermaphroditism." 04/17/1979 - "Familial XX true hermaphroditism and the H-Y antigen." 12/01/1976 - "Presence of H-Y antigen and testis in 46, XX true hermaphroditism, evidence for Y-chromosomal function." 07/01/1978 - "The status of H-Y antigen was studied in 10 intersexual cases (three pure gonadal dysgenesis with XY genotype, three Klinefelter's syndrome, two true hermaphroditism with XX genotype, two male hermaphroditism) and in 18 normal adult subjects (nine males and nine females). "

Related Drugs and Biologics

1.	Antigens
2.	Lipids
3.	Immunosorbents
4.	Immunoglobulins (Immunoglobulin)
5.	Enzymes
6.	Cyproterone Acetate
7.	Interleukin-10 (Interleukin 10)
8.	alpha-beta T-Cell Antigen Receptors (T-Cell Receptor alpha-Chain)
9.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
10.	Minor Histocompatibility Antigens

Related Therapies and Procedures

1.	Transplantation
2.	Liver Transplantation
3.	Castration