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Guanylyl Imidodiphosphate

A non-hydrolyzable analog of GTP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It binds tightly to G-protein in the presence of Mg2+. The nucleotide is a potent stimulator of adenylate cyclase.
Also Known As:
GMP-P(NH)P; Gpp(NH)p; Guanosine 5'-(Beta,Gamma-Imido)Triphosphate; Guanyl-5'-Imidodiphosphate; P(NH)PPG; Guanyl 5' Imidodiphosphate; Imidodiphosphate, Guanylyl; GMP-PNP; 5'-Guanylic acid, monoanhydride with imidodiphosphoric acid
Networked: 62 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Schreiber, G: 2 articles (12/2001 - 07/2000)
2. Avissar, S: 2 articles (12/2001 - 07/2000)
3. Clack, James W: 1 article (07/2008)
4. Yoo, Ki-Yeon: 1 article (01/2006)
5. Won, Moo Ho: 1 article (01/2006)
6. Shin, Hyung-Cheul: 1 article (01/2006)
7. Hwang, In Koo: 1 article (01/2006)
8. Kim, Do-Hoon: 1 article (01/2006)
9. Jung, Boo Kyoung: 1 article (01/2006)
10. Kang, Tae-Cheon: 1 article (01/2006)

Related Diseases

1. Alzheimer Disease (Alzheimer's Disease)
2. Neoplasms (Cancer)
3. Infection
4. Heart Failure
5. Ischemia

Related Drugs and Biologics

1. GTP-Binding Proteins (G-Protein)
2. Acetylcholine (Acetylcholine Chloride)
3. Muscarinic M2 Receptor
4. Magnesium Chloride
5. oxotremorine M
6. Adenylate Cyclase (Adenylyl Cyclase)
7. Forskolin
8. Isoproterenol (Isoprenaline)
9. Guanosine Triphosphate (GTP)
10. Guanosine

Related Therapies and Procedures

1. Microspheres (Microsphere)