Guanethidine

Subscribe to Selected New Research on Guanethidine

579 relevant articles (29 outcomes, 48 trials/studies) found for this Drug

Description: An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.

Also Known As:

((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine; Guanethidine Monosulfate; Guanethidine Sulfate; Guanethidine Sulfate (1:1); Guanethidine Sulfate (1:2); Guanethidine Sulfate (2:1); Guanethidine Sulfate (2:1), 14C-Labeled; Ismelin; Isobarin; Octadine; Oktadin; Monosulfate, Guanethidine; Sulfate, Guanethidine; Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-

Relationship Network

Drug Context: Research Results

Organic Chemicals: 40

dichloro(guanethidine)platinum(II)

guanethidine N-oxide

Experts

1.	Paraskevas, Kosmas I: 2 articles (09/2006 - 07/2005)
2.	Samara, Maria: 2 articles (09/2006 - 07/2005)
3.	Briana, Despina D: 1 article (09/2006)
4.	Michaloglou, Alexandra A: 1 article (09/2006)
5.	Trigka, Aikaterini A: 1 article (07/2005)
6.	Nozawa, Takashi: 1 article (08/2003)
7.	Igawa, Akihiko: 1 article (08/2003)
8.	Inoue, Hiroshi: 1 article (08/2003)
9.	Asanoi, Hidetsugu: 1 article (08/2003)
10.	Fujii, Nozomu: 1 article (08/2003)

Related Diseases

1.	Pain (Aches) 03/01/1996 - "RESULTS: There were no significant differences between groups, but the group receiving guanethidine showed greater improvement in pain relief at all three follow up visits compared with those receiving placebo (9% v 7% at one week; 15% v 6% at four weeks and 36% v 16% at eight weeks)" 01/01/1994 - "The results of this preliminary study suggest that electromotive administration of the the sympatholytic agent, guanethidine, may be useful in the treatment of some types of neuropathic pain" 06/01/1994 - "The present study investigated, for the first time whether pain suppressing, as typically occurring under the IT, would correlate in RSD to the pain relieving effect following a diagnostic guanethidine blockade" 11/29/1991 - "In the present study we have used a recent rat model for neuropathic pain to investigate the effect of the sympatholytic drug guanethidine on changes in behavioural responses evoked by mechanical, heat and cold stimuli and on self-mutilating behaviour" 12/01/1986 - "Compared to placebo, guanethidine produced a decrease in pain (p less than 0.025) and an increase in pinch strength (less than 0.025) over the 2-week duration of the study" Order ALL the reference details at left...
2.	Open-Angle Glaucoma (Glaucoma, Open Angle) 09/01/1972 - "Local guanethidine drops in the treatment of chronic simple glaucoma." 08/01/1971 - "Guanethidine in chronic simple glaucoma." 05/01/1978 - "We present the results of a double-blind trial comparing the efficacy of a single dose combination of guanethidine 3% and adrenaline 0.5% with that of adrenaline 1% alone in reducing the intraocular pressure of eyes suffering from chronic open-angle glaucoma" 04/01/1977 - "Low dosage combined adrenaline-guanethidine formulations in the management of chronic simple glaucoma." 01/01/1979 - "This study showed that an association of adrenaline and guanethidine in drop form, used in cases of open-angle glaucoma, achieved a rapid and lasting stabilisation of intraocular pressure" Order ALL the reference details at left...
3.	Hypertension (High Blood Pressure) 07/01/1976 - "This study refutes the common belief that guanethidine must be reserved only for the treatment of more severe degrees of hypertension." 03/01/1962 - "Guanethidine in the long-term management of hypertension: clinical studies." 08/20/1960 - "Clinical and pharmacological studies with guanethidine in the treatment of hypertension." 10/01/1991 - "To assess the role of the sympathetic nervous system in the development of genetic hypertension, blood pressure (BP) was recorded in conscious adult Lyon hypertensive (LH) and normotensive (LN) rats that had received daily injections of saline or guanethidine at 1-13 wk of age" 12/01/1984 - "Only combined adrenal demedullation and guanethidine pretreatment prevented ABD-induced hypertension, and autonomic blockade normalized MAP in ABD rats" Order ALL the reference details at left...
4.	Reflex Sympathetic Dystrophy (Reflex Sympathetic Dystrophy Syndrome) 12/01/1991 - "The regional guanethidine blocks seemed to be a good treatment for algodystrophy after failure of other treatments." 07/01/1983 - "Regional intravenous guanethidine vs. stellate ganglion block in reflex sympathetic dystrophies: a randomized trial." 06/15/2001 - "Use of intravenous guanethidine for the treatment of complex regional pain syndrome type I is of variable efficacy" 11/01/1996 - "BACKGROUND: Intravenous regional guanethidine Bier block (IVRGBB) has been used predominantly in Europe for treating reflex sympathetic dystrophy (RSD)" 11/01/1996 - "Intravenous guanethidine in patients with reflex sympathetic dystrophy." Order ALL the reference details at left...
5.	Causalgia (Syndrome, Causalgia) 10/01/1987 - "A 25-year-old female developed causalgia following a nerve injury in the left hand, and this was treated successfully with a series of intravenous guanethidine blocks" 04/01/1989 - "Intravenous regional sympathetic block with guanethidine caused only limited improvement in a patient with longstanding causalgia" 05/18/1992 - "Guanethidine blockade was employed in 22 patients with causalgia, hyperpathia and reflex dystrophy in an upper limb" 08/11/1979 - "Relief of causalgia in limbs yb regional intravenous guanethidine." 01/01/1978 - "The causalgia syndrome treated with regional intravenous guanethidine." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Epinephrine (Adrenaline)
2.	Lidocaine (Xylocaine)
3.	Guanethidine
4.	Phentolamine (Z-Max)
5.	Methylprednisolone
6.	Methyldopa (Aldomet)
7.	Reserpine (Serpasil)
8.	Bethanidine (Batel)
9.	Miotics
10.	Carbonic Anhydrase Inhibitors

Related Therapies and Procedures

1.	Sympathectomy (Sympathectomies)
2.	Ligation
3.	Adrenalectomy
4.	Vagotomy
5.	Ganglionectomy

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