Guaifenesin

An expectorant that also has some muscle relaxing action. It is used in many cough preparations.

Also Known As:

Breonesin; Glycerol Guaiacolate; Guaiphenezine; Guiatuss; Humibid; Hytuss; My-301; Scott-Tussin; Ether, Guaiacol Glyceryl; Glyceryl Ether, Guaiacol; Guaiacolate, Glycerol; My 301; My301; Scott Tussin; ScottTussin; Guaiacol Glyceryl Ether; Guaiphenesin; 1,2-Propanediol, 3-(2-methoxyphenoxy)-

Networked: 117 relevant articles (25 outcomes, 18 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Catechols: 121
        Guaiacol: 73
        Guaifenesin: 117
        Broncho-binotal: 2
        duopect: 1
        guaifenesin dinitrate: 1
        hexapneumine: 1
        sagittacin: 1
        beta-(2-methoxyphenoxy)lactic acid
        guaiacylglycerol-beta-coniferyl ether
        guaiacylglycerol-beta-guaiacyl ether
        guaifenesin drug combination caffeine acetaminophen
        linctifed
        veratrylglycerol-beta-guaiacyl ether
        Phenyl Ethers: 8
        Guaiacol: 73
        Guaifenesin: 117
        Methocarbamol: 91
        Broncho-binotal: 2
        duopect: 1
        guaifenesin dinitrate: 1
        hexapneumine: 1
        sagittacin: 1
        beta-(2-methoxyphenoxy)lactic acid
        guaiacylglycerol-beta-coniferyl ether
        guaiacylglycerol-beta-guaiacyl ether
        guaifenesin drug combination caffeine acetaminophen
        linctifed
        veratrylglycerol-beta-guaiacyl ether
- Ethers: 242
  - Methyl Ethers: 19
    - Guaiacol: 73
      - Guaifenesin: 117
        Methocarbamol: 91
        Broncho-binotal: 2
        duopect: 1
        guaifenesin dinitrate: 1
        hexapneumine: 1
        sagittacin: 1
        beta-(2-methoxyphenoxy)lactic acid
        guaiacylglycerol-beta-coniferyl ether
        guaiacylglycerol-beta-guaiacyl ether
        guaifenesin drug combination caffeine acetaminophen
        linctifed
        veratrylglycerol-beta-guaiacyl ether
  - Phenyl Ethers: 8
    - Guaiacol: 73
      - Guaifenesin: 117
        Methocarbamol: 91
        Broncho-binotal: 2
        duopect: 1
        guaifenesin dinitrate: 1
        hexapneumine: 1
        sagittacin: 1
        beta-(2-methoxyphenoxy)lactic acid
        guaiacylglycerol-beta-coniferyl ether
        guaiacylglycerol-beta-guaiacyl ether
        guaifenesin drug combination caffeine acetaminophen
        linctifed
        veratrylglycerol-beta-guaiacyl ether

Experts

1.	Miller, Judi E: 4 articles (01/2019 - 01/2018)
2.	Dicpinigaitis, Peter V: 3 articles (01/2017 - 12/2003)
3.	Solomon, Gail: 3 articles (01/2017 - 06/2009)
4.	Dinç, Erdal: 2 articles (02/2022 - 01/2016)
5.	Boltia, Shereen A: 2 articles (07/2019 - 09/2018)
6.	Albrecht, Helmut: 2 articles (01/2019 - 12/2012)
7.	Shea, Tim: 2 articles (01/2019 - 01/2017)
8.	Singer, Ethan: 2 articles (01/2019 - 09/2018)
9.	Storms, William W: 2 articles (01/2018 - 01/2018)
10.	Albrecht, Helmut H: 2 articles (01/2017 - 01/2017)

Related Diseases

1.	Cough 12/01/1982 - "The efficacy of guaifenesin in reducing cough frequency in young adults with acute respiratory disease was evaluated by both an objective cough counting system and a questionnaire. " 01/01/2019 - "This study found that ER guaifenesin was well tolerated and had a favorable safety profile in otherwise healthy patients suffering from symptoms of cough, thickened mucus and chest congestion associated with URTI. " 01/01/2021 - "Honey was less effective than Guaifenesin for reducing cough severity at 60-minutes in adults with non-specific acute viral RTIs. " 01/01/2017 - "Guaifenesin, a mucoactive drug, acts by loosening mucus in the airways and making coughs more productive. " 12/01/2003 - "Our results demonstrate that guaifenesin inhibits cough reflex sensitivity in subjects with URI, whose cough receptors are transiently hypersensitive, but not in healthy volunteers. "
2.	Respiratory Tract Infections (Respiratory Tract Infection) 12/27/2012 - "We compared the efficacy of extended-release guaifenesin with placebo for treatment of symptoms of upper respiratory tract infection using subjective efficacy assessments in a pilot study and confirmed precision of assessments in a validation study. " 12/27/2012 - "Patient-reported outcomes to assess the efficacy of extended-release guaifenesin for the treatment of acute respiratory tract infection symptoms." 01/01/2019 - "The aim of this study was to further elucidate the safety profile of ER guaifenesin in patients with acute upper respiratory tract infection (URTI). " 01/01/2017 - "Progress is being made to establish clinical models and measures that are more appropriate for studying symptomatic relief with guaifenesin in acute respiratory infections. " 05/01/2014 - "Guaifenesin has no effect on sputum volume or sputum properties in adolescents and adults with acute respiratory tract infections."
3.	Chronic Bronchitis 10/23/2019 - "The Role of Guaifenesin in the Management of Chronic Mucus Hypersecretion Associated with Stable Chronic Bronchitis: A Comprehensive Review." 10/23/2019 - "Here we review the pathophysiology and consequences of chronic mucus hypersecretion and examine the evidence for the use of guaifenesin in patients with stable chronic bronchitis." 10/23/2019 - "Although guaifenesin has a Food and Drug Administration Over-the-Counter (OFC) Monograph indication to "help loosen phlegm (mucus) and thin bronchial secretions in patients with stable chronic bronchitis," there is limited published evidence of either mechanism of action or clinical efficacy in this disease state. " 01/01/2018 - "Daily use of guaifenesin (Mucinex) in a patient with chronic bronchitis and pathologic mucus hypersecretion: A case report." 01/01/2019 - "Improved quality of life associated with long-term use of guaifenesin in a patient with chronic obstructive pulmonary disease (COPD) & stable chronic bronchitis: A case report."
4.	Bronchitis 01/01/2017 - "Role of guaifenesin in the management of chronic bronchitis and upper respiratory tract infections." 03/04/2019 - "This exploratory study assessed the safety of the combination of sulfamethoxazole, trimethoprim and guaifenesin (STG) in adult and pediatric patients with acute bronchitis according to local labelling in Peru. " 03/04/2019 - "A pilot study of safety of sulfamethoxazole, trimethoprim and guaifenesin in pediatric and adult patients with acute bronchitis." 01/01/1974 - "Changes in the fibre system and viscosity of the sputum of bronchitis during treatment with bromhexine and guaiphenesin (guaiacol glyceryl ether)." 04/26/2023 - "The efficacy of a new combination drug containing ambroxol, guaifenesin, and levosalbutamol in the treatment of productive cough in adult patients with acute bronchitis is superior to the efficacy of Ascoril Expectorant. "
5.	Common Cold 10/01/2017 - "1. A new oral liquid formulation combining guaifenesin, pseudoephedrine and hydrocodone is effective in improving the symptoms of common cold. " 10/01/2017 - "3. The newly developed oral liquid formulation combining guaifenesin, pseudoephedrine and hydrocodone was safe and well tolerated and might provide a reliable alternative to the branded formulation for patients with common colds." 12/01/2019 - "A rapid, simple and efficient liquid chromatographic method was developed for simultaneous determination of three active ingredients namely, chlorpheniramine maleate, phenylephrine hydrochloride and guaifenesin along with sodium benzoate preservative common cold medications (syrups) and the method was validated based on the International Conference on Harmonization (ICH) and United State Pharmacopeia (USP) guidelines. " 03/01/2010 - "Guaifenesin compound pseudoephedrine hydrochloride oral solution showed significant efficacy and safety in children for treatment of cough, expectoration, nasal congestion and runny nose caused by common cold or acute tracheobronchitis." 08/01/2021 - "The six active pharmaceutical molecules under study, namely, paracetamol, guaifenesin, pseudoephedrine, ibuprofen, chlorpheniramine, and dextromethorphan, are widely used in common cold products. "

Related Drugs and Biologics

1.	Expectorants (Mucolytics)
2.	Dextromethorphan (Racemethorphan)
3.	Antitussive Agents (Antitussives)
4.	Pseudoephedrine
5.	Codeine (Codeine Phosphate)
6.	Hydrocodone (Dihydrocodeinone)
7.	Diphenhydramine (Benadryl)
8.	Glycerol (Glycerine)
9.	Zinc
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Anesthesia
4.	Tourniquets
5.	Operative Surgical Procedures