|1.||Dalbeth, Nicola: 93 articles (01/2016 - 05/2005)|
|2.||Schumacher, H Ralph: 43 articles (01/2016 - 06/2004)|
|3.||Stamp, Lisa K: 37 articles (01/2016 - 11/2009)|
|4.||Choi, Hyon K: 37 articles (10/2015 - 03/2004)|
|5.||Becker, Michael A: 31 articles (10/2015 - 07/2003)|
|6.||Perez-Ruiz, Fernando: 25 articles (01/2016 - 08/2002)|
|7.||Singh, Jasvinder A: 25 articles (12/2015 - 06/2007)|
|8.||Merriman, Tony R: 23 articles (12/2015 - 11/2009)|
|9.||McQueen, Fiona M: 23 articles (09/2015 - 06/2008)|
|10.||Ichida, Kimiyoshi: 22 articles (01/2015 - 01/2008)|
|1.||Uric Acid (Urate)IBA
07/01/2001 - "In addition, after lead chelating therapy, urate clearance markedly improved after a reduction of the BLS of patients with CRI and gout (study group 67.9 +/- 80.0% vs. control group 1.2 +/- 34.0%, P = 0.0056). "
03/01/1992 - "This study supports the hypothesis that genetic factors exert an important control on the renal clearance of urate, which determines some of the familiarity of hyperuricaemia and gout."
07/01/2000 - "In this study it was investigated whether dietary measures, reported to be beneficial in IR, have serum uric acid (SU) and lipid lowering effects in gout. "
06/01/2007 - "Successful management of chronic gout depends on reducing body pools of urate. "
01/01/1998 - "Interestingly, no significant rise in the plasma, urinary and clearance of uric acid was observed in gout patients with uric acid clearance > 6.0 mL/min (lower normal limit). "
|2.||Allopurinol (Remid)FDA LinkGeneric
05/01/2014 - "Gouticin 500 mg twice daily is more effective than the allopurinol 300mg once daily in the management of gout."
03/01/2014 - "Gout is a major health problem in Polynesians and allopurinol, the drug of choice for the management gout, appears to be less effective in Polynesian patients. "
07/01/2014 - "Allopurinol is effective for the control of gout and its long-term complications when taken consistently. "
03/01/2005 - "Therapy with allopurinol has been effective for those manifestations the disease shares with gout. "
09/01/1989 - "We concluded that the intermittent administration of allopurinol as given here is less effective in controlling symptoms of gout than continuous therapy."
12/01/2010 - "Low-dose and high-dose colchicine have comparable efficacy in the treatment of acute gout, but high dose carries significantly greater risk of adverse effects."
01/01/2006 - "Colchicine is regarded as beneficial in the treatment of acute gout, but has a high frequency of gastrointestinal adverse events. "
01/01/2014 - "Based upon only two published trials, there is low-quality evidence that low-dose colchicine is likely to be an effective treatment for acute gout. "
04/10/1987 - "Colchicine has the smallest benefit-to-toxicity ratio of drugs that are effective for acute gout. "
02/02/2011 - "Small doses of colchicine are useful in the treatment of gout. "
03/01/2015 - "In open-label extension studies, 3-5 years' treatment with febuxostat maintained a target sUA level of <6.0 mg/dL in most patients; sustained reduction in sUA level was associated with near elimination of gout flares and improved tophus status. "
11/01/2013 - "Febuxostat, initially introduced in the United States in 2009, was the first new treatment option for gout in over 40 years. "
05/01/2009 - "Febuxostat: a new treatment for hyperuricaemia in gout."
11/01/2013 - "Utilization management strategies likely result in gaps in gout treatment; 35% of patients with a denied febuxostat claim in this study population did not fill a prescription for any chronic gout therapy within a month of the claim denial. "
01/01/2013 - "Preservation of renal function during gout treatment with febuxostat: a quantitative study."
|5.||polyethylene glycol-uricaseFDA Link
01/01/2014 - "This study showed pegloticase is probably beneficial in the management of tophi in gout, in terms of resolution of tophi, but with a high risk of adverse infusion reactions. "
09/01/2012 - "Two recent Phase III trials have found pegloticase to be effective in the management of treatment-failure gout. "
11/01/2011 - "For patients with refractory and tophaceous gout, intravenous pegloticase is a new treatment option. "
11/01/2011 - "For patients with refractory and tophaceous gout, intravenous pegloticase is a new treatment option."
07/01/2012 - "Improved health-related quality of life and physical function in patients with refractory chronic gout following treatment with pegloticase: evidence from phase III randomized controlled trials."
04/01/2014 - "Because we have recently found that two 6-(propan-2-yl)-4-methyl-morpholine-2,5-diones, as novel non-purine xanthine oxidase inhibitors, may give promise to be used in the treatment of gout, in this review we have included a study of molecular interactions of the selected cyclodidepsipeptides with xanthine oxidase using idTarget web server. "
03/15/2015 - "Xanthine oxidase (XO) inhibitors have been widely used for the treatment of gout. "
03/01/2015 - "The results demonstrate that UF-LC-MS combined with HSCCC might provide not only a powerful tool for screening and isolating xanthine oxidase inhibitors in complex samples but also a useful platform for discovering bioactive compounds for the prevention and treatment of gout."
01/01/2015 - "What are the effects of xanthine oxidase inhibitors to prevent gout in people with prior acute episodes? "
09/01/2014 - "We selected Pleurotus ostreatus from among several edible mushrooms because it has high anti-gout xanthine oxidase (XOD) inhibitory activity. "
|7.||Indomethacin (Indometacin)FDA LinkGeneric
01/01/1983 - "Oxametacin, a new non steroidal anti-inflammatory compound, with analgesic, antipyretic and anti-inflammatory properties comparable to those of indomethacin, has been claimed to be effective in treatment of acute attacks of gout. "
01/01/1993 - "It is as safe and effective as indomethacin in the treatment of acute gout, and is particularly useful in patients with contraindications to therapy with nonsteroidal antiinflammatory drugs."
12/12/2013 - "Histopathological results showed that high and medium dose of Shuang-Qi gout capsule and Indomethacin reduced gouty joint inflammatory features, while the high dose of Shuang-Qi gout capsule showed a better therapeutic effect. "
03/01/2008 - "The first group (Group I) included 27 patients taking gout prescription I; the second group (Group II) included 27 patients taking gout prescription II; the third group (Group III) included 28 patients taking gout prescription III; and the fourth group (control group) included 25 patients taking indomethacin and Benzobromarone as a control group. "
11/01/2000 - "This case report describes an elderly man, prescribed indomethacin for gout, who presented with psychosis."
|8.||Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
05/01/2015 - "The remarkable clinical improvement in joint symptoms within 24 h and in glycemic control during a 6-month period gives anakinra a potential therapeutic role in the management of gout and type 2 diabetes. "
01/01/2015 - "Anakinra was effective in most patients (90%), with higher complete clinical response rates for Schnitzler's syndrome, gout, CAPS and AOSD. "
07/01/2015 - "Improved renal function in diabetic patients with acute gout treated with anakinra."
03/01/2011 - "First observation of the efficacy of IL-1ra to treat tophaceous gout of the lumbar spine."
12/01/2010 - "To evaluate the efficacy of anakinra for patients with acute gout. "
08/01/2008 - "An extended adjustment for BMI, creatinine, gout medication, and alcohol intake improved P values to a range of 10(-14) to 10(-20). "
04/01/2015 - "While lower eGFR categories showed significant associations with gout in multivariable-adjusted models (prevalence ratio 1.46 for eGFR <30 compared with eGFR ≥60, 95% confidence interval 1.21-1.77), associations between gout and higher urinary albumin-to-creatinine ratio in this CKD population were not significant. "
01/01/2014 - "The functional state of kidneys in 100 patients with GA was estimated from creatinine clearance (CC) calculated by the Cockroft-Gault formula on day 2 after their examination in a polyclinic and prescription of NAIA to stop the gout attack or during the first days after hospitalization. "
01/01/2013 - "Reduced creatinine clearance is associated with early development of subcutaneous tophi in people with gout."
11/01/2007 - "The genotype AA at polymorphism -863C/A in a recessive model showed a significant association with developing gout independent of hyperuricaemia, abnormal creatinine, higher TG, GPT and alcohol consumption."
|10.||Interleukin-1 (Interleukin 1)IBA
12/01/2009 - "The study of autoinflammatory diseases revealed mechanisms of IL-1 mediated organ damage and provided concepts to a better understanding of the pathogenesis of more common diseases such as gout and Type 2 diabetes which show initial promising results with IL-1 blocking therapy."
01/01/2007 - "The effectiveness of IL-1 inhibition in hereditary autoinflammatory syndromes with mutations in the NALP3 protein suggested that IL-1 inhibition might also be effective in relieving the inflammatory manifestations of acute gout. "
01/01/2011 - "Recent studies suggest that orchestration of the MSU-induced inflammatory response is dependent on the proinflammatory cytokine IL-1β, underlined by promising results in early IL-1 inhibitor trials in gout patients. "
01/01/2005 - "The purpose of this study was to examine whether interleukin-1 receptor antagonist (IL-1Ra) gene polymorphism is a marker of susceptibility to or of the clinical characteristics of gout in Taiwanese patients. "
01/01/2016 - "Uncontrolled IL-1 activation is a central component of some inflammatory diseases, including rare hereditary syndromes with mutations in inflammasome-associated genes or more frequent diseases such as gout, characterized by neutrophil infiltration and IL-1 activation. "
|1.||Chinese Traditional Medicine (Traditional Chinese Medicine)
12/01/2014 - "The roots and rhizomes of Smilax riparia, called 'Niu-Wei-Cai' in traditional Chinese medicine, are believed to be effective in treating the symptoms of gout. "
09/15/2014 - "The roots and rhizomes of Smilax riparia (SR), called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating gout symptoms. "
01/01/2014 - "The roots and rhizomes of Smilax riparia, called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating gout symptoms. "
07/01/2015 - "Qigui Tongfeng tablet (QLTFT) is a traditional Chinese medicine with good effect for treating gout. "
11/18/2014 - "The roots and rhizomes of Smilax riparia (SR), called "Niu-Wei-Cai" in traditional Chinese medicine (TCM), are believed to be effective in treating hyperuricemia and gout symptoms. "
|2.||Transplantation (Transplant Recipients)
08/15/2011 - "Gout and transplantation: new treatment option-same old drug interaction."
04/01/2015 - "In this study, we report a case of a 62-year-old male renal transplant recipient who had tophi as the first clinical sign of gout. "
04/01/2015 - "Dermal tophus: a complication of gout in a kidney transplant recipient."
07/01/2013 - "Managing new-onset gout in pediatric renal transplant recipients: when, how, to what extent."
11/01/2011 - "Acute gout at engraftment following hematopoietic transplantation."
07/01/2015 - "We present a case of recurrent PTLD of the bone in a heart transplant patient that was misdiagnosed as gout for several years. "
01/01/2007 - "Spinal gout in a renal transplant patient: a case report and literature review."
09/01/2006 - "Tophaceous gout of the first costochondral junction in a heart transplant patient."
08/01/2006 - "Of those who returned to work post transplant 48% required time off work because of gout. "
08/01/2006 - "Of those patients who developed gout post transplant 70% had an attack at least every 3 months. "
|4.||Drug Therapy (Chemotherapy)
01/01/2006 - "Although pharmacotherapy is generally safe and effective, there are caveats and limitations to all gout therapies. "
06/01/2003 - "Evidence from well-designed clinical studies evaluating drug therapies for gout is limited. "
06/01/2003 - "Relevant clinical studies and review articles were found using the text- and keyword-search term gout alone and in combination with epidemiology, prevalence, incidence, complications, outcome, quality of life, economics, cost, prevention or drug therapy. "
07/01/2015 - "We should now focus on rational pharmacotherapy to significantly improve gout care. "
03/01/2015 - "In the last decade, there has been major progress in the pharmacotherapy of gout. "
01/01/2000 - "The female patients in this study had a lower mean age at onset of gout than in previous studies, which was attributed to the inclusion of renal transplantation patients. "
10/01/2013 - "Acute gout after renal transplantation with notable hypouricemia."
08/01/2006 - "Hypouricaemic therapy should be considered early in those who develop gout post renal transplantation. "
11/27/2005 - "New-onset gout after kidney transplantation: incidence, risk factors and implications."
11/27/2001 - "Episodes of gout are common in the setting of renal transplantation. "