Gossypol

A dimeric sesquiterpene found in cottonseed (GOSSYPIUM). The (-) isomer is active as a male contraceptive (CONTRACEPTIVE AGENTS, MALE) whereas toxic symptoms are associated with the (+) isomer.

Also Known As:

Gossypol Dipotassium Salt; Gossypol Sodium Salt; Gossypol, (+)-Isomer; Gossypol, (+-)-Isomer; Gossypol, (-)-Isomer; Dipotassium Salt, Gossypol; Sodium Salt, Gossypol; (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-

Networked: 534 relevant articles (32 outcomes, 119 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lin, Young C: 14 articles (03/2013 - 01/2002)
2.	Wang, Shaomeng: 13 articles (08/2010 - 07/2003)
3.	Xu, Liang: 12 articles (01/2019 - 02/2005)
4.	Ye, Weiping: 10 articles (03/2013 - 05/2006)
5.	Chang, Hsiang-Lin: 7 articles (07/2010 - 01/2002)
6.	Dowd, Michael K: 7 articles (07/2010 - 01/2002)
7.	Kögel, Donat: 6 articles (03/2019 - 07/2010)
8.	Wu, Daocheng: 6 articles (01/2019 - 04/2009)
9.	Yang, Dajun: 6 articles (08/2013 - 07/2003)
10.	Sugimoto, Yasuro: 6 articles (07/2010 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2011 - "(-)-Gossypol, a natural BH3-mimetic and small-molecule Bcl-2 inhibitor, shows promise in ongoing phase II clinical trials for human cancers. " 01/01/2020 - "Our study revealed a previously unknown anti-cancer mechanism of gossypol with potential to develop a new class of neddylation inhibitors." 08/28/2014 - "The in vivo study of the anti-cancer effect of (-)-G-PgSHAs revealed that (-)-G-PgSHAs had a more enhanced tumor-suppression effect and reduced systemic toxicity compared with free (-)-gossypol and (±)-G-PgSHAs (P < 0.05). " 02/01/2012 - "Although previous studies demonstrated anticancer activities of gossypol through the induction of apoptosis, the molecular mechanism(s) responsible for the inhibitory effects of gossypol on the metastatic behavior of cancer cells remain to be elucidated. " 12/01/2009 - "Further studies with endothelial cells should be done to verify the anti-angiogenic effect of gossypol enantiomers in cancer treatment."
2.	Prostatic Neoplasms (Prostate Cancer) 10/01/2010 - "Among different applications of gossypol and irradiation (before, after and concurrent) in prostate cancer cells, the best results were observed by the application of gossypol 24 h before irradiation. " 01/01/2011 - "A natural BH3-mimetic, small-molecule inhibitor of Bcl-2, (-)-gossypol, shows promise in ongoing phase II and III clinical trials for human prostate cancer. " 02/01/2010 - "The current studies were undertaken to examine the chemotherapeutic efficacy of gossypol on human prostate cancer cell lines and prostate tumor-initiating cells. " 10/01/2010 - "Gossypol, a natural polyphenolic compound extracted from the cotton plant, is one of the agents the efficacy of which has been investigated in the treatment of prostate cancer for this purpose. " 02/01/2012 - "The natural BH3-mimetic (-)-gossypol shows promising efficacy in ongoing phase II/III clinical trials for human prostate cancer. "
3.	Inflammation (Inflammations) 01/01/2023 - "Administration of two NCOA3 inhibitors, gossypol (GSP) and SI-2 hydrochloride (SHC), significantly alleviated inflammation and improved the outcomes of CIA mice. " 06/08/2022 - "Gossypol caused intestinal inflammation, oxidative stress, and apoptosis. " 06/08/2022 - "Intestinal Microbiota Mediates Gossypol-Induced Intestinal Inflammation, Oxidative Stress, and Apoptosis in Fish." 03/01/2019 - "Dietary gossypol reduced intestinal immunity and aggravated inflammation in on-growing grass carp (Ctenopharyngodon idella)." 02/01/2013 - "The present data suggest that gossypol suppresses the inflammation in vitro and vivo, and may be a potential therapeutic candidate for the treatment of inflammatory disorders."
4.	Asthenozoospermia 10/01/2023 - "In a gossypol-induced mouse asthenozoospermia model, administration of SC-sEV@miR-24-3p inhibitor significantly improved sperm motility, in vitro fertilization success, and blastocyst formation rates. " 01/01/2022 - "In a gossypol-induced mouse asthenozoospermia model, the administration of an ATP-loaded HFn nanocage through a tail vein injection significantly improved sperm motility. "
5.	Hypokalemia 01/01/1984 - " The following points suggest the main directions for future research in the scope of pharmacology and toxicology: hypokalemia -- exploration of the contributing factor(s), means to prevent its occurrence, mechanism(s) of development, production of animal model; irreversibility; general toxicological assessment; and studies on the mechanism of action, which also may be helpful in the development of gossypol analogue(s) exhibiting satisfactory antifertility and minimal toxic effects." 02/01/2009 - "However, clinical trials showed that the major side effect of gossypol was hypokalemia. " 11/01/1997 - "To study the mechanism of gossypol-induced hypokalemia. " 11/01/1992 - "Gossypol, in clinical trials as an antifertility drug for men in China, was associated with episodes of hypokalemia. " 09/01/1981 - "[Preliminary study on gossypol in causing hypokalemia (author's transl)]."

Related Drugs and Biologics

1.	Cottonseed Oil (Cottonseed)
2.	Phytochemicals
3.	Vitamin E
4.	Potassium
5.	Cisplatin (Platino)
6.	Salts
7.	Doxorubicin (Adriamycin)
8.	Gemcitabine
9.	Temozolomide (Temodar)
10.	apogossypol

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Drug Therapy (Chemotherapy)
4.	Contraception (Birth Control)
5.	Injections