Gonorrhea

03/01/2005 - "This will be very helpful for the further construction of preventive vaccines directed against Neisseria gonorrhoeae infection."
01/01/2019 - "The global spread of multidrug-resistant gonorrhea has spurred efforts to develop a safe and effective vaccine against gonorrhea. "
11/02/2023 - "Herein, we explored the versatile and effective Tag/Catcher-AP205 capsid VLP (cVLP) vaccine platform to address the urgent need for the development of an effective and safe vaccine against gonorrhea. "
01/01/2019 - "While no clinically effective vaccines against gonorrhea have been developed we present direct and indirect evidence that a vaccine is not only possible, but may already exist. "
01/01/2023 - "To explore whether healthy vaccinee bias influenced such findings, we examined the effectiveness of MenB-FHbp, a non-OMV vaccine that is not protective against gonorrhea. "

08/01/1995 - "Our data suggest that most prepubertal children with gonorrhea are symptomatic at initial presentation and are cured after recommended treatment with ceftriaxone. "
10/01/2014 - "If oral treatment were 75% effective against decreased susceptibility gonorrhea, exclusive ceftriaxone use would likely increase cure rates in persons with decreased susceptibility gonorrhea, but could diminish them in persons with gonorrhea overall. "
01/01/2021 - "Following its establishment globally, the lineage has served as a reservoir for the repeated emergence of clones fully resistant to the ESC ceftriaxone, an essential drug for effective treatment of gonorrhea. "
07/01/1989 - "The Centers for Disease Control now recommends ceftriaxone for the first line treatment of gonorrhea but there are no data as to its use in children for this indication. "
10/01/1987 - "We retrospectively analyzed the efficacy of ceftriaxone in a single dose of 125 mg given intramuscularly for treatment of uncomplicated gonorrhea. "

01/01/2020 - "gonorrhea in an immunocompetent host, treated successfully with a prolonged antibiotic course."
10/01/1989 - "A more economic approach would be to use gonorrhea treatment that is effective against both genital and pharyngeal gonorrhea or to obtain pharyngeal cultures in those adolescents returning for test-of-cure cultures after antibiotic treatment for genital gonorrhea."
05/01/2014 - "Full AZM resistance is now emerging in this clone together with reduced susceptibility to 3GC, threatening the future efficacy of these antibiotics as therapeutic options for treatment of gonorrhea. "
08/01/1993 - "Dr Hawley explains how prevention and detection of gonorrhea can be improved and describes new, single-dose treatment with oral antibiotics."
11/01/2018 - "The report emphasizes the importance of gene exchange among neisserial species and development of antibiotic resistance in gonococci, both of which have ramifications for detection of resistance markers and efficacy of antibiotic treatment regimens for gonorrhea."

01/01/1984 - " This study evaluates the efficacy of TAP compared with the standard regimen of Aqueous Procain Penicillin + Probenicid in the treatment of uncomplicated genital gonorrhea in men in Central African Republic. "
01/01/2005 - "The ethical dilemma of inducing a disease with an unpredictable outcome persisted until the 1940s, when gonorrhea could be reliably cured by penicillin."
09/01/1980 - "The efficacy of penicillin regimen in treatment of women with culture positive gonorrhea."
12/01/1975 - "[Is there a possibility for gonorrhea patients who cured themselves with peroral penicillin to escape medical evidence]."
08/01/1986 - "Unique strains of Neisseria gonorrhoeae causing epidemic gonorrhea during the penicillin era: a study of isolates from Denmark."

03/01/1994 - "Azithromycin Gonorrhea Study Group."
01/01/2023 - "Prior Exposure to Azithromycin and Azithromycin Resistance Among Persons Diagnosed With Neisseria gonorrhoeae Infection at a Sexual Health Clinic: 2012-2019."
01/01/2022 - "A test-of-cure is recommended for all cases of pharyngeal gonorrhea and for rectal chlamydia if treated with azithromycin. "
01/01/2022 - "The incidence rates of gonorrhea and azithromycin-resistant N. "
10/19/2021 - "Using free and directed molecular dynamics (MD) simulations, we analyzed the interactions between MtrD and azithromycin, a transport substrate of MtrD, and a last-resort clinical treatment for multidrug-resistant gonorrhea. "

04/01/2014 - "Recent antimicrobial resistance data for Neisseria gonorrhoeae are lacking in Uganda, where, until 2010, ciprofloxacin was the nationally recommended first-line treatment of presumptive gonorrhea. "
08/01/2012 - "The prominence of multidrug resistance suggests that using other classes of antimicrobial drugs for purposes other than treating gonorrhea helped increase the prevalence of ciprofloxacin-resistant strains that are also resistant to those drugs."
04/01/2014 - "In this study, we analyzed historical ciprofloxacin resistance data and gonorrhea incidence data to examine the possible effect of antimicrobial drug resistance on gonorrhea incidence at the population level. "
03/15/2001 - "Although ciprofloxacin is one of the recommended drugs of choice for the treatment of gonorrhea, in vitro resistance to this drug has been observed in surveillance studies and case reports from many parts of the world, including Bangladesh. "
10/24/2023 - "We used a novel CRISPR-based technology to develop a rapid test that does not require laboratory infrastructure for both diagnosing gonorrhea and predicting whether ciprofloxacin can be used in its treatment, a one-time oral pill. "

10/26/2022 - "Cefixime (CFM) is currently not recommended as a first-line treatment for gonorrhea due to the increasing number of resistant strains worldwide. "
01/01/1997 - "A single 400 mg oral dose of cefixime was effective for the treatment of gonorrhea and was well tolerated by the pregnant women."
09/01/1993 - "Single-dose cefixime 400 mg orally is effective in the treatment of uncomplicated gonorrhea. "
01/01/1997 - "Open study of the safety and efficacy of a single oral dose of cefixime for the treatment of gonorrhea in pregnancy."
09/01/1993 - "To assess the efficacy of 200 mg cefixime in the treatment of uncomplicated gonorrhea. "

01/01/2022 - "The emerging cephalosporin-resistant Neisseria gonorrhoeae poses an urgent threat to the continued efficacy of the last-line monotherapy for gonorrhea. "
10/01/2008 - "Following anecdotal reports of the treatment failure of gonorrhea with oral extended-spectrum cephalosporins, the current study was undertaken to determine the antimicrobial susceptibility pattern and molecular characteristics of isolates of N. "
01/01/2022 - "The emergence of clinical isolates producing plasmid β-lactamases that can hydrolyze cephalosporins, the mainstay treatment for gonorrhea, may be a serious threat. "
10/01/2016 - "Gonorrhea in Indonesia: High Prevalence of Asymptomatic Urogenital Gonorrhea but No Circulating Extended Spectrum Cephalosporins-Resistant Neisseria gonorrhoeae Strains in Jakarta, Yogyakarta, and Denpasar, Indonesia."
06/01/2013 - "A retrospective comparative study of 2-drug oral and intramuscular cephalosporin treatment regimens for pharyngeal gonorrhea."

04/01/1989 - "Therefore, the combination of epiciline-probenecid is a valid alternative for routine treatment of acute uncomplicated gonorrhea."
04/01/1989 - "We treated 142 patients with acute uncomplicated gonorrhea with a single oral dose of epiciline-probenecid. "
09/05/1968 - "[Gonorrhea therapy with a combination of probenecid and benzylsodiumpenicillin. "
01/01/1976 - "To monitor the efficacy of the 1972 United States Public Health Service recommended treatment regimens for uncomplicated gonorrhea, we studied 9008 patients who were randomly assigned either to aqueous procaine penicillin G, 4.8 million units intramuscularly plus 1 g of oral probenecid, or to one of the three other recommended regimens. "
08/01/1986 - "Cefuroxime axetil alone is effective for urethral gonorrhea in males; rectal gonorrhea probably requires additional probenecid."

08/01/2005 - "To understand why clinical trials failed to demonstrate efficacy of nonoxynol-9 in preventing gonorrhea. "
06/01/1994 - "The use of nonoxynol-9 for protection against cervical gonorrhea."
10/01/1998 - "The first "real-life" controlled trial of the spermicide Nonoxynol 9 (N-9) has indicated that N-9 may be ineffective in reducing rates of HIV, gonorrhea, or chlamydia. "
01/01/1997 - "A 2-year Family Health International (FHI) study concluded that a spermicidal film containing nonoxynol-9 (N-9) is safe, but does not provide any additional protection for women against HIV, gonorrhea, or chlamydia. "
07/01/2001 - "There was a significantly higher incidence of gonorrhea in the nonoxynol-9 group than in the placebo group. "

07/01/2020 - "Unfortunately, Neisseria gonorrhoeae, the etiological agent of gonorrhea, has acquired nearly all known mechanisms of antimicrobial resistance (AMR), thereby compromising the efficacy of antimicrobial therapy. "
01/01/1990 - "Enzymic therapy helped reduce the length of inpatient therapy of a patient by 5.93 days on an average in cases with orchidoepididymitis and by 14.64 days in gonorrhea relapses, with the economic effect per worker being 131.4 and 307.2 rubles, respectively."
11/01/1981 - "All patients received either therapy were cured of gonorrhea. "
03/01/1979 - "Five patients had positive cultures for gonorrhea at the time of initial examination and all were cured by therapy. "
01/01/2022 - "A Statewide Mixed-Methods Study of Provider Knowledge and Behavior Administering Expedited Partner Therapy for Chlamydia and Gonorrhea."

02/01/2004 - "Among 429 participants with known Gc/Ct exposure, consistent condom use was associated with a significant reduction in prevalent gonorrhea and chlamydia (30% vs. 43%; adjusted prevalence odds ratio = 0.42, 95% confidence interval: 0.18, 0.99). "
08/01/1995 - " Furthermore, condom use in a core group is more effective than condom use in the non-core group for reducing the prevalence of gonorrhea and HIV. "
09/01/2001 - "Special NIH review confirms condoms effective against transmission of HIV, gonorrhea."
11/09/2001 - "Irregular condom use was not protective against HIV or STD and was associated with increased gonorrhea/Chlamydia risk (OR, 1.44; 95% CI, 1.06-1.99). "
10/01/2020 - "For a gel-PSI efficacy of 30%, a net reduction in cumulative gonorrhea incidence was projected, relative to the status quo, for any ratio of proportion of condom users "downgrading" to proportion of noncondom users "upgrading" to gel-PSI use of less than 2.6. "

04/21/2009 - "This study was conducted to evaluate antigonococcal activity of 22 Thai medicinal plants selected from the plants popularly used in Thai folk medicine for treatment of gonorrhea. "
09/15/2015 - "In Oriental countries, the dried fruits of Schisandra chinensis are extensively used in traditional medicine to treat asthma, gonorrhea, and other diseases. "
03/01/2010 - "In the traditional medicine of Sri Lanka and India, Salacia reticulata bark is considered orally effective in the treatment of rheumatism, gonorrhea, skin disease and diabetes. "
05/01/2021 - "In China, species from the Paulownia genus (Paulowniaceae) are widely used in traditional medicine for the treatment of infectious diseases, such as gonorrhea and erysipelas. "
11/01/2016 - "In Korean folk medicine, Melandrium firmum Rohrbach (Caryophyllaceae) has been used to treat various diseases, including anuria, breast cancer, and gonorrhea. "

07/01/1985 - "The results suggest that not only barrier methods but also other types of contraception were associated with protection against gonorrhea in females. "
07/01/1985 - " Extrapolation of the findings of this study suggests that nearly 200,000 of the 250,000 cases of gonorrhea reported in the US in 1983 could have been averted by use of barrier methods of contraception on the part of noncontraceptors and those using nonbarrier methods."
07/01/1985 - " In some cases, the relationship observed in this study between use of specific contraceptive methods and lower rates of gonorrhea may be biological. "
01/01/2021 - "We estimated the weighted proportion of providers (or their health center or practice) who required blood pressure measurement, pelvic examination (bimanual examination and cervical inspection), Papanicolaou (Pap) smear, clinical breast examination (CBE), and chlamydia and gonorrhea (CT/GC) screening before initiating hormonal or intrauterine contraception (IUC) for healthy women. "
09/01/2017 - "The following services could be offered: (i) HIV, chlamydia and gonorrhea screening, (ii) hepatitis B virus screening and vaccination, (iii) provision and information about contraceptive methods, (iv) presentation of the university health center services. "

01/01/1994 - "These findings have implications not only for the treatment of gonorrhea but also for other situations where intramuscular injections utilizing a diluent may be necessary."
10/01/1981 - "Twenty-seven episodes of gonorrhea occurring in children less than 15 years of age were treated with an intramuscular injection of cefuroxime, 25 mg/kg. Gonococci were eliminated from genital, pharyngeal, and anal sites in all cases. "
04/01/1984 - "The high plasma levels were parallelled by high concentrations in SBF, with peaks amounting to 8.4 +/- 1.0 micrograms/ml. Peak concentrations in CBF ranged from 8.1 to 15.7 micrograms/ml. Thus, the pharmacokinetic behavior of ceftizoxime given as a single intramuscular injection of 1 g explained the excellent clinical results of this regimen in uncomplicated gonorrhea."
01/01/1978 - "Systemic toxic were encountered in eight of 10,469 patients during or immediately following the intramuscular injection of 4,800,000 units of procaine penicillin G for the treatment of gonorrhea. "
11/10/1944 - "(3) Eight of the patients with gonorrhea and the one patient with urethritis were cured (bacteriologically and clinically) by this single intramuscular injection of penicillin."