Gonadotropins

Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.

Also Known As:

Networked: 5103 relevant articles (123 outcomes, 439 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Young, Jacques: 19 articles (01/2022 - 12/2003)
2.	Atwood, Craig S: 16 articles (01/2021 - 11/2002)
3.	Legro, Richard S: 13 articles (01/2021 - 09/2006)
4.	Smith, Mark A: 13 articles (01/2018 - 11/2002)
5.	Brailly-Tabard, Sylvie: 12 articles (01/2022 - 05/2009)
6.	Bowen, Richard L: 12 articles (01/2021 - 11/2002)
7.	Maggi, Mario: 12 articles (01/2021 - 09/2006)
8.	Huhtaniemi, Ilpo: 12 articles (01/2019 - 01/2003)
9.	Nie, Min: 11 articles (01/2022 - 05/2015)
10.	Tsukamura, Hiroko: 11 articles (01/2022 - 06/2011)

Related Diseases

1.	Infertility (Sterility) 04/01/1987 - "Whereas constant administration of LHRHA by a slow release system seems very useful for long-term reversible suppression of follicular maturation, further studies should evaluate the clinical usefulness of combined LHRHA/gonadotropin treatment in cases of infertility." 10/01/2021 - "This study examined 197 gonadotropin-stimulated IUI cycles of 148 women diagnosed with unexplained infertility from February 2019 to November 2020. " 04/01/2019 - "The aim of this study is to investigate the clinical value of AMH in predicting pregnancy in younger and older women with unexplained infertility undergoing gonadotropin stimulation and IUI. " 10/01/2017 - "This study aims to introduce a new tool (the Follicular Sensitivity Index; FSI) for objective assessment of follicular responsiveness to exogenous gonadotropins and to evaluate its ability to predict the clinical pregnancy rate in women with unexplained infertility or tubal factor undergoing IVF/ICSI. " 01/01/2014 - "Study population consisted of 387 gonadotropin stimulated IUI cycles performed for unexplained infertility. "
2.	Hypogonadism (Hypergonadotropic Hypogonadism) 03/01/2012 - "Treatment with gonadotropins has been shown to be effective in males affected by hypogonadotropic hypogonadism. " 07/01/1980 - "Investigation of the therapeutic efficacy of menopause gonadotropin (MPG), made in the USSR, in patients with hypogonadotropic hypogonadism demonstrated MPG to possess the FSH-activity. " 09/01/1988 - "4. Hypogonadism normalized in 2 patients and improved in one patient, whereas plasma gonadotropins remained low in the 2 postmenopausal women. " 09/12/1985 - "We evaluated the efficacy of gonadotropin treatment in stimulating spermatogenesis in men with hypogonadotropic hypogonadism. " 01/01/2023 - "However, data are often conflicting regarding the severity, timing or even the real clinical relevance of these complications, although these studies often lack essential information such as gonadotropin levels or the underlying cause of hypogonadism. "
3.	Precocious Puberty 08/01/1991 - "A dose of more than 30 micrograms/kg of TAP-144-SR is effective in suppressing gonadotropins and causing improvement of clinical symptoms, and appears to be useful in treating children with central precocious puberty." 02/01/1986 - "Finally, the detailed characterization of children with precocious puberty has helped to define more precisely a subset of patients whose precocity occurs in the absence of demonstrable gonadotropin secretion.(ABSTRACT TRUNCATED AT 400 WORDS)" 12/01/2013 - "The aim of this study was to investigate the diagnostic accuracy of basal gonadotropin levels for girls with suspected precocious puberty and to evaluate the factors affecting positive results of the GnRHST. " 01/01/2011 - "Gonadotropin stimulation test is the gold standard to document precocious puberty. " 05/11/2023 - "The study included 30 patients (29 girls, 1 boy) with idiopathic gonadotropin-dependent precocious puberty. "
4.	Ovarian Hyperstimulation Syndrome 01/01/2015 - "It is as effective as gonadotropins in terms of pregnancy and live birth rates, but without the risks of ovarian hyperstimulation syndrome and multiple pregnancies. " 11/01/2014 - "During assisted reproductive techniques, AMH assay is very useful choosing the ovarian stimulation protocol and the dose of gonadotropins to begin with, in order to limit the risks of ovarian hyperstimulation syndrome or on the other hand, cancellation of cycles due to poor ovarian response. " 01/28/2022 - "Since a minimal or even zero dose of gonadotropins are required in the IVM procedure, the occurrence of ovarian hyperstimulation syndrome (OHSS) is eliminated. " 04/01/2011 - "The subject of the study is to compare the clinical characteristics of recombinant gonadotropins versus urinary ones focused on the daily dose of FSH achieving FSH threshold and the risk of multifollicular development in ovulation induction before intrauterine insemination, number of follicles and oocytes, the risk of ovarian hyperstimulation syndrome (OHSS), total consumption of FSH, cost effectiveness and expected pregnancy rate during in vitro fertilization technique. " 03/01/2011 - "Studies have shown that ovulation and pregnancy rates are comparable between ovulation induction with gonadotropins and LOD, but LOD avoids the risks of multiple pregnancy and ovarian hyperstimulation syndrome. "
5.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 07/08/2022 - "The objective of this study was to manipulate the gonadotropin stimulation protocol to mimic polycystic ovary syndrome (PCOS) and assess the resulting changes in ovarian steroidogenesis. " 01/01/2020 - "In this study, we investigated in an androgenized rat model the involvement of autophagy and mitochondrial dynamics in granulosa cells in the pathogenesis of polycystic ovarian syndrome (PCOS) and its modulation by exogenous gonadotropin (eCG). " 06/01/2004 - "Studies using pharmacological gonadotropin stimulation suggest that ovarian steroidogenesis is abnormal in the polycystic ovary syndrome (PCOS). " 12/01/1995 - "To study ovarian stimulation and response patterns during a gonadotropin step-down dose regimen for induction of ovulation by applying a decremental dose regimen in polycystic ovary syndrome (PCOS) patients. " 10/25/2023 - "Genetic Variants of Steroidogenesis and Gonadotropin Pathways and Polycystic Ovary Syndrome Susceptibility: A Systematic Review and Meta-analysis."

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	Clomiphene (Clomifene)
3.	Hormones (Hormone)
4.	Testosterone (Sustanon)
5.	Androgens
6.	Letrozole (Femara)
7.	Metformin (Glucophage)
8.	Estradiol (Delestrogen)
9.	Steroids
10.	Leuprolide (Lupron)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Duration of Therapy
4.	Diathermy
5.	Combination Drug Therapy (Combination Chemotherapy)