Glycylglycine (Diglycine)

The simplest of all peptides. It functions as a gamma-glutamyl acceptor.

Also Known As:

Diglycine; Glycyl-Glycine; Glycylglycine Hydrochloride; Glycylglycine Monohydrochloride; N-Glycylglycine; Glycyl Glycine; Hydrochloride, Glycylglycine; Monohydrochloride, Glycylglycine; N Glycylglycine; Glycine, N-glycyl-

Networked: 29 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - Glycylglycine: 29
        (glycylglycinato-kappa3O,N,N')(2-methyl-1H-benzimidazole-kappaN3)copper(II) trihydrate
        N-2,4-dinitrophenyl (bis)glycine
        phenylglycylglycine

Experts

1.	Cao, Li: 1 article (05/2022)
2.	Chen, Ligang: 1 article (05/2022)
3.	Duan, Jie: 1 article (05/2022)
4.	Tu, Jiao: 1 article (05/2022)
5.	Xiao, Xiao: 1 article (05/2022)
6.	Hara, Risa: 1 article (01/2021)
7.	Ishigaki, Mika: 1 article (01/2021)
8.	Ito, Atsushi: 1 article (01/2021)
9.	Miyazaki, Shun-Ichi: 1 article (01/2021)
10.	Murayama, Kodai: 1 article (01/2021)

Related Diseases

1.	Dehydration (Water Stress) 05/01/1990 - "We conclude that glycine and glycyl-glycine supplemented oral rehydration solution does not have any therapeutic advantage in the treatment of acute gastroenteritis with moderate dehydration caused predominantly by rotavirus." 12/01/1991 - "One hundred and eight male adults (mean age 33 +/- 1.7 years) presenting with watery diarrhoea of less than 48 hours duration at home prior to hospitalization and with clinically evident (grade II, severe) dehydration were admitted into a randomized double-blind clinical trial; 54 were treated with standard oral rehydration solution (ORS)--WHO formulation containing citrate--and 54 with an improved ORS formulation which contained, in addition to the standard formula, maltodextrin 20 g (instead of glucose), glycine 4 g and glycyl-glycine 4 g. " 01/01/2021 - "Because peptide synthesis can be monitored by evaluating the increasing number of amide bonds with dehydration occurring between amino acids, polyglycine, which has the simplest structure among polyamino acids, was studied, and the key bands whose absorption intensities increased with the elongation of the chain length, such as the bands attributed to glycine, diglycine, triglycine, and tetraglycine, were searched. "
2.	Sudden Infant Death (SID) 12/01/2003 - "A quantum mechanical and molecular mechanical (QM + MM) direct dynamics classical trajectory simulation is used to study energy transfer and fragmentation in the surface-induced dissociation (SID) of N-protonated diglycine, (gly)2H+. The peptide ion collides with the hydrogenated diamond [111] surface. "
3.	Hemorrhage 01/01/1954 - "The effect of glycylglycine on the buffer capacity of the blood after hemorrhage; studies with rabbits."
4.	Neoplasms (Cancer) 02/06/2015 - "We have generated a large set of USP1 structural variants, including a catalytically inactive form (C90S), non-phosphorylatable (S313A) and phosphomimetic (S313D) mutants, deletion mutants lacking potential UAF1 binding sites, a mutant (GG/AA) unable to undergo autocleavage at the well-characterized G670/G671 diglycine motif, and four USP1 mutants identified in tumor samples that cluster around this cleavage site (G667A, L669P, K673T and A676T). " 08/01/2018 - "In present investigation, self-assembled nanomicelles of amphiphilic clotrimazole glycyl-glycine (CLT-GG-SANMs) analogue were customized for augmenting drug delivery, permeability and apoptosis in B16F1 mouse melanoma cancer cells both in vitro and in vivo following intratumoral (i.t.) route of administration. " 04/28/2012 - "To evaluate the biological preference of metallopeptide drugs in cancer cells, a new dinuclear copper(II) complex [Cu(2)(glygly)(2)(ppz)(H(2)O)(4)]·2H(2)O (1) (glygly = glycyl glycine anion and ppz = piperazine), was designed and synthesized as topoisomerase I inhibitor. "
5.	Infections 07/01/1974 - "Effect of systemic infections on glycylglycine absorption rate from the human jejunum in vivo." 12/01/1977 - "With this experimental design the mean rate of histidine absorption was significantly higher in the infection compared with the control group, but mean rates for glycine absorption from glycylglycine were not significantly different. " 05/01/2001 - "The potential for the development of resistance in oxacillin-resistant Staphylococcus aureus (ORSA) to lysostaphin, a glycylglycine endopeptidase produced by Staphylococcus simulans biovar staphylolyticus, was examined in vitro and in an in vivo model of infection. " 12/01/1977 - "Jejunal absorption rates of L-histidine (from a 100 mmole/liter solution) and glycylglycine (from a 50 mmole/liter solution) were determined with a souble-lumen tube perfusion system in vivo in 12 Zambian African men; six had acute bacterial pneumonia (infection group) and six had no clinical evidence of a bacterial infection (control group). "

Related Drugs and Biologics

1.	Glycine (Aminoacetic Acid)
2.	Glucose (Dextrose)
3.	Solutions
4.	maltodextrin
5.	Citric Acid (Citrate)
6.	ORALIT (ORS)
7.	Peptides (Polypeptides)
8.	Diamond
9.	Buffers
10.	Amino Acids

Related Therapies and Procedures

1.	Fluid Therapy (Oral Rehydration Therapy)
2.	Therapeutics