Glycine-tRNA Ligase

An enzyme that activates glycine with its specific transfer RNA. EC 6.1.1.14.

Also Known As:

Gly-tRNA Ligase; Glycyl-tRNA Synthetase; Gly tRNA Ligase; Glycine tRNA Ligase; Glycyl tRNA Synthetase; Ligase, Gly-tRNA; Ligase, Glycine-tRNA; Synthetase, Glycyl-tRNA; Glycyl T RNA Synthetase; Glycine:tRNA(Gly) ligase (AMP-forming)

Networked: 66 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Carbon-Oxygen Ligases
      - Amino Acyl-tRNA Synthetases: 433
        Glycine-tRNA Ligase: 66
        human GARS1 protein
        S cerevisiae GRS1 protein
        S cerevisiae GRS2 protein

Experts

1.	Burgess, Robert W: 9 articles (12/2019 - 09/2006)
2.	Yang, Xiang-Lei: 9 articles (12/2019 - 06/2007)
3.	Talbot, Kevin: 6 articles (01/2018 - 06/2007)
4.	Antonellis, Anthony: 5 articles (12/2019 - 05/2003)
5.	Wei, Na: 5 articles (12/2019 - 10/2015)
6.	Jordanova, Albena: 5 articles (07/2016 - 05/2003)
7.	Kim, Sunghoon: 4 articles (01/2022 - 03/2012)
8.	Bai, Ge: 4 articles (01/2018 - 10/2015)
9.	Seburn, Kevin L: 4 articles (07/2016 - 09/2006)
10.	He, Weiwei: 4 articles (04/2016 - 07/2011)

Related Diseases

1.	Type 2D Charcot-Marie-Tooth disease 01/01/2018 - "Dominant mutations in glycyl-tRNA synthetase (GlyRS) cause a subtype of Charcot-Marie-Tooth neuropathy (CMT2D). " 01/01/2017 - "The mechanism by which dominantly inherited mutations in the housekeeping gene GARS, which encodes glycyl-tRNA synthetase (GlyRS), mediate selective peripheral nerve toxicity resulting in Charcot-Marie-Tooth disease type 2D (CMT2D) is still largely unresolved. " 12/01/2016 - "The findings are similar to those found in CMT2D caused by mutations in the GARS gene, encoding glycyl-tRNA synthetase." 07/15/2016 - "Charcot-Marie-Tooth type 2D neuropathy (CMT2D) is caused by dominant mutations in glycyl tRNA synthetase (GARS). " 04/21/2016 - "Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase."
2.	Peripheral Nervous System Diseases (PNS Diseases) 07/26/2011 - "Here we focus on mutations in glycyl-tRNA synthetase (GlyRS) that cause an axonal form of Charcot-Marie-Tooth (CMT) diseases, the most common hereditary peripheral neuropathies. " 07/01/2009 - "An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy." 01/01/2022 - "Charcot-Marie-Tooth disease type 2D (CMT2D), is a hereditary peripheral neuropathy caused by mutations in the gene encoding glycyl-tRNA synthetase (GARS1). " 08/01/2014 - "Neuropathic pain model of peripheral neuropathies mediated by mutations of glycyl-tRNA synthetase." 09/21/2006 - "Of the many inherited Charcot-Marie-Tooth peripheral neuropathies, type 2D (CMT2D) is caused by dominant point mutations in the gene GARS, encoding glycyl tRNA synthetase (GlyRS). "
3.	Myositis (Idiopathic Inflammatory Myopathies) 08/01/2014 - "Pulmonary pathologic manifestations of anti-glycyl-tRNA synthetase (anti-EJ)-related inflammatory myopathy." 03/01/2021 - "Early predominant inflammatory myopathy in anti-glycyl-tRNA synthetase (EJ) antibody positive antisynthetase syndrome." 04/20/2014 - "Although anti-glycyl-tRNA synthetase antibodies (anti-EJ) are mainly found in patients with inflammatory myopathy, information on their clinical significances is limited, partly due to a lack of commercially available tests. " 11/18/1994 - "Primary structure and functional expression of human Glycyl-tRNA synthetase, an autoantigen in myositis." 01/01/2019 - "This study aimed to clarify the clinical features, the serum level of autoantibodies, and cytokine of myositis patients with anti-EJ antibody, which targets glycyl tRNA-synthetase (GlyRS). "
4.	Type V Distal Hereditary Motor Neuronopathy 11/01/2014 - "Distal spinal muscular atrophy type V (dSMA-V), a hereditary axonal neuropathy, is a glycyl-tRNA synthetase (GRS)-associated neuropathy caused by a mutation in GRS. " 06/13/2006 - "Glycyl-tRNA synthetase mutations are a frequent cause of familial distal hereditary motor neuropathy type V but, because of the reduced penetrance of the disease, could also account for isolated cases." 06/13/2006 - "The G526R glycyl-tRNA synthetase gene mutation in distal hereditary motor neuropathy type V." 01/01/2020 - "Pathogenic variants in the Glycyl-tRNA synthetase gene cause the allelic disorders Charcot-Marie-Tooth disease type 2D and distal hereditary motor neuropathy type V. We describe clinical features in 8 unrelated patients found to have Glycyl-tRNA synthetase variants by Next Generation Sequencing. " 01/01/2018 - "Glycyl-tRNA synthetase (GARS) gene mutations have been reported to be associated with Charcot-Marie-Tooth disease 2D and distal hereditary motor neuropathy type V (dHMN-V). "
5.	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 01/01/2023 - "Gain-of-function mutations in the housekeeping gene GARS1, which lead to the expression of toxic versions of glycyl-tRNA synthetase (GlyRS), cause the selective motor and sensory pathology characterizing Charcot-Marie-Tooth disease (CMT). " 01/01/2021 - "Glycyl-tRNA synthetase mutations are associated to the Charcot-Marie-Tooth disease type-2D. " 01/01/2019 - "We report the first family with a glycyl-tRNA synthetase (GARS) mutation with autosomal dominant intermediate Charcot-Marie-Tooth disease (DI-CMT). " 06/12/2007 - "Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase." 01/01/2018 - "Glycyl-tRNA synthetase (GARS) gene mutations have been reported to be associated with Charcot-Marie-Tooth disease 2D and distal hereditary motor neuropathy type V (dHMN-V). "

Related Drugs and Biologics

1.	Autoantibodies
2.	Cytokines
3.	Histone Deacetylase 6
4.	Enzymes
5.	Gly Transfer RNA
6.	Proteins (Proteins, Gene)
7.	Transfer RNA (tRNA)
8.	Glycine (Aminoacetic Acid)
9.	Antibodies
10.	Amino Acids

Related Therapies and Procedures

1.	Therapeutics