Glutathione Transferase (Glutathione S-Transferase)

A transferase that catalyzes the addition of aliphatic, aromatic, or heterocyclic FREE RADICALS as well as EPOXIDES and arene oxides to GLUTATHIONE. Addition takes place at the SULFUR. It also catalyzes the reduction of polyol nitrate by glutathione to polyol and nitrite.

Also Known As:

Glutathione S-Transferase; Transferase, Glutathione; Glutathione Organic Nitrate Ester Reductase; Glutathione S-Transferase 3; Glutathione S-Transferase A; Glutathione S-Transferase B; Glutathione S-Transferase C; Glutathione S-Transferase III; Glutathione S-Transferase P; Glutathione Transferase E; Glutathione Transferase mu; Glutathione Transferases; Heme Transfer Protein; Ligandin; Yb-Glutathione-S-Transferase; Glutathione Lyase, S-Hydroxyalkyl; Glutathione S Alkyltransferase; Glutathione S Aryltransferase; Glutathione S Epoxidetransferase; Glutathione S Transferase; Glutathione S Transferase 3; Glutathione S Transferase A; Glutathione S Transferase B; Glutathione S Transferase C; Glutathione S Transferase III; Glutathione S Transferase P; Lyase, S-Hydroxyalkyl Glutathione; P, Glutathione S-Transferase; Protein, Heme Transfer; S Hydroxyalkyl Glutathione Lyase; S-Alkyltransferase, Glutathione; S-Aryltransferase, Glutathione; S-Epoxidetransferase, Glutathione; S-Transferase 3, Glutathione; S-Transferase A, Glutathione; S-Transferase B, Glutathione; S-Transferase C, Glutathione; S-Transferase III, Glutathione; S-Transferase P, Glutathione; S-Transferase, Glutathione; Transfer Protein, Heme; Transferase E, Glutathione; Transferase mu, Glutathione; Transferases, Glutathione; Glutathione S-Alkyltransferase; Glutathione S-Aryltransferase; Glutathione S-Epoxidetransferase; Ligandins; S-Hydroxyalkyl Glutathione Lyase; RX:glutathione R-transferase

Networked: 4015 relevant articles (66 outcomes, 519 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Alkyl and Aryl Transferases: 180
      - Glutathione Transferase: 4015
        glutathione S-transferase M1: 506
        Glutathione S-Transferase pi: 425
        glutathione S-transferase T1: 228
        glutathione S-transferase alpha: 107
        leukotriene-C4 synthase: 37
        microsomal glutathione S-transferase-I: 14
        glutathione S-transferase Mu 2: 6
        glutathione transferase M3-3: 2
        sulfobromophthalein-glutathione conjugase: 2
        glutathione S-transferase 9.5-2: 1
        glutathione S-transferase Yc: 1
        mGSTA4-4: 1
        Arabidopsis DHAR1 protein
        Arabidopsis GST1 protein
        Arabidopsis GST11 protein
        Arabidopsis GSTF2 protein
        Arabidopsis GSTF6 protein
        Arabidopsis GSTF8 protein
        Arabidopsis GSTF9 protein
        Arabidopsis GSTU13 protein
        Arabidopsis GSTU19 protein
        Arabidopsis GSTU26 protein
        Arabidopsis GSTZ1 protein
        Arabidopsis TRANSPARENT TESTA 19 protein
        C elegans cblc-1 protein
        C elegans GSTO-1 protein
        Culicoides variipennis sonorensis cvgst1 protein
        cyanocobalamin beta-ligand transferase
        Drosophila GstE1 protein
        Drosophila Gste14 protein
        Drosophila GSTE6 protein
        Drosophila GSTE7 protein
        Drosophila GstO1 protein
        E coli YfcF protein
        E coli YfcG protein
        glutathione S-transferase 9.5-1
        human glutathione S-transferase A3-3
        human glutathione transferase T1-1
        human GSTA1 protein
        human GSTK1 protein
        human GSTM3 protein
        human GSTM4 protein
        human GSTM5 protein
        human GSTO1 protein
        human GSTO2 protein
        human GSTT2 protein
        human GSTZ1 protein
        Leukotriene C4 Synthase Deficiency
        MdGST-6A
        mouse disulfide-bond A oxidoreductase-like protein DsbA-L
        mouse glutathione S-transferase M5
        mouse glutathione transferase kappa
        mouse GSTA2 protein
        mouse GSTA3 protein
        mouse GSTA4-4 protein
        mouse Gsto1 protein
        mouse Gsto2 protein
        mouse Gstt2 protein
        mouse Gstz1 protein
        mouse MGST2 protein
        Octopus S-crystallin protein
        Periplaneta americana Per a 5 allergen
        Plasmodium falciparum GST1 protein
        rat glutathione transferase 5-5
        rat Gsta3 protein
        rat Gstt2 protein
        rat Gstz1 protein
        rat kappa glutathione S-transferase 1-1
        recombinant GST-Nef protein
        recombinant GST-RAP protein
        S cerevisiae 1-Cys thiol transferase protein
        Schistosoma haematobium 28 kDa gluthathione S-transferase antigen
        Schistosoma mansoni 28-kilodalton glutathione S-transferase antigen
        Xenopus glutathione transferase sigma
        Xenopus GSTM1-1 protein
        zebrafish gstr protein

Experts

1.	Pljesa-Ercegovac, Marija: 18 articles (03/2022 - 05/2010)
2.	Savic-Radojevic, Ana: 18 articles (03/2022 - 05/2010)
3.	Simic, Tatjana: 18 articles (03/2022 - 05/2010)
4.	Fukushima, Shoji: 15 articles (10/2018 - 08/2003)
5.	Matic, Marija: 13 articles (03/2022 - 05/2010)
6.	Nelson, William G: 11 articles (01/2021 - 01/2002)
7.	Saadat, Mostafa: 11 articles (01/2017 - 06/2006)
8.	Sultana, Sarwat: 11 articles (09/2013 - 08/2004)
9.	Coric, Vesna: 10 articles (03/2022 - 04/2014)
10.	Wanibuchi, Hideki: 10 articles (10/2018 - 08/2003)

Related Diseases

1.	Neoplasms (Cancer) 02/25/2010 - "Out of the single gene perturbations, activation of glutathione S-transferase P (GSTP1) gene was by far the most effective in blocking the cancer phenotype. " 05/01/2006 - "The 24-mo fermentation was the most effective in preventing cancer by decreasing tumor formation and increasing natural killer cell activity in spleens and glutathione S-transferase activity in livers of mice. " 11/01/2020 - "This study shows that a vital component of the pathway CRAF is directly impacted by an end product of the cascade, glutathione transferases (GST) P1 (GSTP1), driving a previously unrecognized autocrine cycle that sustains proliferation of mKRAS and mBRAF cancer cells, independent of oncogenic stimuli. " 01/01/2020 - "The aim of this study is to investigate the effect of Glutathione S-transferase A1 (GSTA1) on the prognosis of HCC and to understand its role in tumor progression and the possible mechanism. " 01/01/2019 - "In this study, we investigated specific genetic variants of three candidate genes belonging to the glutathione-S-transferase superfamily that have been implicated in increased risk of cancers. "
2.	Body Weight (Weight, Body) 05/01/1987 - "SKF525-A given intraperitoneally (50 mg/kg body weight) to Sprague-Dawley rats in a single dose promoted a significant reduction in cytosolic glutathione S-transferase (GST) activities 0.5 and 1 h after injection. " 05/27/2022 - "Total body weight (TBW) and a single-nucleotide polymorphism of glutathione-S-transferase A1 (GSTA1 SNP) displayed a significant impact on volume of distribution and metabolite clearance, respectively. " 01/01/2019 - "The animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. " 07/01/2008 - "Occurrence of glutathione S-transferase placental form (GST-P)-positive hepatocytes was examined, using 15 Wistar rats of both sexes each orally administered 2,3,7,8-tetrabromo-dibenzo-p-dioxin (TBDD) by gavage at a single dose of 0, 10, 30, 100 or 300 microg/kg body weight. " 11/01/2001 - "Body weight, lung weight and tissue glutathione-S-transferase activity were, however, not altered. "
3.	Carcinogenesis 07/01/2015 - "The aim of the study is to investigate the clinical significance of glutathione-S-transferase GSTM1, GSTT1, and NQO1 c.609C>T (rs1800566) genetic polymorphisms in cervical carcinogenesis. " 01/01/2011 - "The present study evaluated the roles of glutathione S-transferase omega 1 (GSTO1) and GSTO2 polymorphisms in UC carcinogenesis. " 01/01/2010 - "However, mice, a major animal model for the study of AFB1 carcinogenesis, are resistant, due to high constitutive expression, in the mouse liver, of glutathione S-transferase A3 subunit (mGSTA3) that is lacking in humans. " 01/01/2002 - "Enhancement of the activities of their phase II counterparts, such as glutathione S-transferase might have also played a critical role in post-initiation suppression in a study of tongue carcinogenesis. " 02/08/1980 - "Recent studies include the possible role of ligandin in chemical carcinogenesis, diagnosis of inflammatory and neoplastic disease of the liver and kidney, and participation in intracellular transport. "
4.	Infections 01/01/1992 - "Sm28, a glutathione-S-transferase, induces significant protection against schistosome infection in rodents and nonhuman primates. " 10/31/2023 - "Glutathione transferase photoaffinity labeling displays GST induction by safeners and pathogen infection." 12/22/2021 - "Following HSV-1 infection of human corneal epithelial cells (HCECs), endogenous Rac1 activity was upregulated by glutathione S-transferase (GST) pulldown assay. " 09/01/2021 - "Glutathione-S-transferase omega 1 and nurse cell formation during experimental Trichinella infection." 02/01/2021 - "An Ixodes scapularis glutathione S-transferase plays a role in cell survival and viability during Langat virus infection of a tick cell line."
5.	Inflammation (Inflammations) 12/17/2019 - "Omega class glutathione transferases, GSTO1-1 and GSTO2-2, exhibit different activities involved in regulation of inflammation, apoptosis and redox homeostasis. " 05/01/2013 - "Yet, little remains known about the regulation of allergic inflammation by glutathione S-transferase P1 in human asthmatics. " 01/01/2013 - "At sacrifice, the livers of SD rats treated with DEN and HFD exhibited marked development of glutathione S-transferase placental form (GST-P)-positive foci, a hepatic preneoplastic lesion, and this was associated with hepatic steatosis, oxidative stress and inflammation, and hepatocyte proliferation. " 11/15/2008 - "Mutated glutathione-S-transferase reduced airway inflammation by limiting oxidative stress and Th2 response." 01/01/2007 - "Down-regulation of glutathione transferase A1 (GSTA1) expression has profound implications in cytoprotection against toxic by-products of lipid peroxidation produced during inflammation. "

Related Drugs and Biologics

1.	Enzymes
2.	Glutathione (Reduced Glutathione)
3.	Superoxide Dismutase
4.	Glutathione Peroxidase
5.	Catalase
6.	Nitric Oxide (Nitrogen Monoxide)
7.	Antioxidants
8.	Glutathione Reductase (Glutathione-Disulfide Reductase)
9.	Proteins (Proteins, Gene)
10.	Malondialdehyde (Propanedial)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Oral Administration
3.	Chemoprevention
4.	Lenses
5.	Neoadjuvant Therapy