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Glutathione Synthase (Glutathione Synthetase)

One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of glutathione from gamma-glutamylcysteine and glycine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.3.
Also Known As:
Glutathione Synthetase; Synthase, Glutathione; Synthetase, Glutathione; gamma-L-Glutamyl-L-cysteine:glycine ligase (ADP-forming)
Networked: 32 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Wei, Y-H: 1 article (04/2014)
2. Lee, H-T: 1 article (04/2014)
3. Lee, C-S: 1 article (04/2014)
4. Tsai, C-Y: 1 article (04/2014)
5. Lin, C-S: 1 article (04/2014)
6. Daliva, John: 1 article (01/2014)
7. Chen, Yung C: 1 article (01/2014)
8. Oliveira, Juliana G: 1 article (01/2014)
9. Regiani, Vitor R: 1 article (01/2014)
10. Nguyen, Truongson: 1 article (01/2014)

Related Diseases

1. Neoplasms (Cancer)
2. Acidosis
3. Anoxia (Hypoxia)
07/01/1997 - "By contrast, anoxia exposure increased the activities of GR in liver and red muscle (by 52 and 80%), glutathione synthetase (GS) in white muscle (by 300%), and GRN in white muscle (by 400%). "
10/01/1985 - "Survival curves of glutathione synthetase deficient human fibroblasts: correlation between radiosensitivity in hypoxia and glutathione synthetase activity."
08/01/2007 - "During anoxia exposure, there was a boost of antioxidant defenses as shown by an increase of the specific activity of the enzymes catalase, glutathione-S-transferase, glutathione peroxidase, glutathione-synthase, malic enzyme, and NADP-dependent isocitrate dehydrogenase. "
04/01/2014 - "We measured plasma levels of the oxidative DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) and leucocyte mRNA expression levels of the genes encoding the 8-OHdG repair enzyme human 8-oxoguanine DNA glycosylase 1 (hOGG1), the anti-oxidant enzymes copper/zinc superoxide dismutase (Cu/ZnSOD), manganese superoxide dismutase (MnSOD), catalase, glutathione peroxidase-1 (GPx-1), GPx-4, glutathione reductase (GR) and glutathione synthetase (GS), the mitochondrial biogenesis-related proteins mtDNA-encoded ND 1 polypeptide (ND1), ND6, ATPase 6, mitochondrial transcription factor A (Tfam), nuclear respiratory factor 1(NRF-1), pyruvate dehydrogenase E1 component alpha subunit (PDHA1), pyruvate dehydrogenase kinase isoenzyme 1 (PDK-1) and hypoxia inducible factor-1α (HIF-1α) and the glycolytic enzymes hexokinase-II (HK-II), glucose 6-phosphate isomerase (GPI), phosphofructokinase (PFK), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase A (LDHa). "
4. Hepatocellular Carcinoma (Hepatoma)
5. Contagious Ecthyma (Orf)

Related Drugs and Biologics

1. Glutamate-Cysteine Ligase
2. Doxorubicin (Adriamycin)
3. Glutathione (Reduced Glutathione)
4. Enzymes
5. Glutathione Reductase (Glutathione-Disulfide Reductase)
6. gamma-glutamylcysteine
7. Glutathione Peroxidase
8. Buthionine Sulfoximine
9. Pyrrolidonecarboxylic Acid (Pyroglutamic Acid)
10. Oxidoreductases

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)