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Glutathione Reductase (Glutathione-Disulfide Reductase)

Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2.
Also Known As:
Glutathione-Disulfide Reductase; Reductase, Glutathione; Reductase, Glutathione-Disulfide; NADPH:oxidized-glutathione oxidoreductase
Networked: 854 relevant articles (16 outcomes, 73 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Sultana, Sarwat: 10 articles (09/2013 - 08/2004)
2. Peng, Wen-Huang: 9 articles (05/2015 - 08/2007)
3. Popova, T N: 8 articles (11/2015 - 06/2002)
4. Stojiljković, Vesna: 5 articles (09/2015 - 08/2008)
5. Todorović, Ana: 5 articles (09/2015 - 08/2008)
6. Kasapović, Jelena: 5 articles (03/2012 - 08/2008)
7. Islam, Fakhrul: 5 articles (01/2011 - 09/2003)
8. Khan, Naghma: 5 articles (07/2005 - 08/2004)
9. Zhang, Yong-An: 4 articles (11/2015 - 08/2015)
10. Jiang, Wei-Dan: 4 articles (11/2015 - 08/2015)

Related Diseases

1. Body Weight (Weight, Body)
2. Hypertension (High Blood Pressure)
01/01/2003 - "The aim of this study was to assess the activity of CAT, GSH-Px, SOD and glutathione reductase in children with a family history of premature CHD who did not present any other major risk factors of CHD (diabetes, obesity, dyslipidaemia or hypertension). "
08/01/1991 - "The duration of nephropathy, the onset of arterial hypertension (AH), a family history of AH, uric syndrome, intravenous urographic evidence, glomerular filtration rate (GFR) determined from endogenous creatinine, the cellular membranes studied in erythrocytes by ureal hemolysis, and blood levels of thiol and disulfide groups by back amperometric titration, red blood cell activity of glutathione reductase and glucoso-6-phosphate dehydrogenase were evaluated in 108 patients with essential hypertension (EH), mesangial proliferative glomerulonephritis who had elevated and normal blood pressures and 18 healthy subjects. "
12/01/1982 - " The following are some results: 1) there was a more varied diet among older women, those with higher education, and those with higher income; 2) 29.5% were obese; 3) obese women were less well educated and had lower incomes; 4) hypertension was found in 14 women; 5) 14 women had hemoglobin values below 12 g/1000 ml, 8 had hematocrit values of less than 38%, 6) 75% were low or deficient in plasma folacin values, 7) erythrocyte folacin values were low in 57.5%; erythrocyte glutathione reductase assays for riboflavin status showed 11 women in the deficient range and plasma carotene values were deficient in 2, low in 9; 8) women taking OCs had lower erythrocyte folacin levels but higher plasma retinol levels; and 9) the more children a woman was raising the poorer was her riboflavin status. "
11/01/2005 - "This study evaluated the activity of cardiac and renal antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione reductase (GR)] and whether chronic treatment with tempol, a cell membrane-permeable SOD mimetic, ameliorates the hypertension of hyperthyroidism. "
06/01/2005 - "This study analyzed whether hypertension induced by N(omega)-nitro-l-arginine methyl ester (L-NAME) is associated with dysregulation of the main antioxidant enzymes (superoxide dismutase [SOD], catalase, glutathione peroxidase [GPX], and glutathione reductase [GR]) and whether chronic administration of tempol ameliorates this hypertension. "
3. Anoxia (Hypoxia)
4. Neoplasms (Cancer)
5. Infection

Related Drugs and Biologics

1. Glutathione Peroxidase
2. Superoxide Dismutase
3. Catalase
4. Glutathione (Reduced Glutathione)
5. Enzymes
6. Glutathione Transferase (Glutathione S-Transferase)
7. Vitamin E
8. Antioxidants
9. Ascorbic Acid (Vitamin C)
10. tempol

Related Therapies and Procedures

1. Oral Administration
2. Drug Therapy (Chemotherapy)
3. Remission Induction
4. Transplantation (Transplant Recipients)
5. Lenses