|2.||Sickle Cell Trait
|1.||Baird, J Kevin: 9 articles (06/2015 - 11/2004)|
|2.||White, Nicholas J: 8 articles (02/2014 - 01/2008)|
|3.||Drakeley, Chris: 7 articles (01/2015 - 01/2009)|
|4.||Leopold, Jane A: 7 articles (02/2013 - 08/2003)|
|5.||Kwiatkowski, Dominic P: 6 articles (10/2015 - 08/2005)|
|6.||Lang, Florian: 6 articles (05/2015 - 01/2002)|
|7.||Bancone, Germana: 6 articles (04/2015 - 01/2008)|
|8.||Bousema, Teun: 6 articles (01/2015 - 01/2009)|
|9.||Matsuoka, Hiroyuki: 6 articles (01/2011 - 01/2006)|
|10.||Huang, Ching-Shan: 6 articles (01/2008 - 07/2002)|
|1.||Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA
06/01/2012 - "In this study we aimed to determine the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in a Lebanese population and the clinical outcomes and associated adverse events encountered amongst affected patients. "
02/01/2011 - "The purpose of this study was to analyze a targeted screening program for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDdef) and clinical outcomes of G6PD-deficient vs G6PD normal newborns. "
08/01/2010 - "This study determined the epidemiological, clinical and laboratory profile of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Baghdad (central Iraq) and compared it with previous data from Mosul (northern Iraq). "
01/01/2009 - "This study aimed to compare the detection rates of glucose-6-phosphate dehydrogenase (G6PD) deficiency in neonates by fluorescent spot test (FST), enzyme assay and molecular methods, and to identify which method was a significant predictor of severe hyperbilirubinaemia. "
05/01/2007 - "The purpose of this study was to evaluate the aetiology of indirect hyperbilirubinaemia and the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in newborns who were admitted to Vali-e-Asr Hospital in Zanjan City during the period 2001-2003. "
11/01/2004 - "This review supports a recommendation for a regimen of 0.5 mg/kg primaquine daily for 14 days, on the basis of superior efficacy and good tolerability and safety in nonpregnant persons without glucose-6-phosphate dehydrogenase deficiency."
01/01/2012 - "Such a shift in practice necessitates investigation of the safety and efficacy of primaquine when administered with those therapies, and the toxicity profile of such combination treatments, particularly in patients with glucose-6-phosphate dehydrogenase deficiency. "
01/01/2015 - "Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency."
01/01/2014 - "Testing for G6PD deficiency is not widely available, and so whilst it is widely recommended, primaquine is often not prescribed. "
01/01/2013 - "Individuals with G6PD deficiency are at risk of undergoing acute haemolysis when exposed to 8‒aminoquinoline-based drugs, such as primaquine. "
|3.||glucose-6-phosphate dehydrogenase A-IBA
01/01/2014 - "It has been documented that G6PD deficiency in sub-Saharan Africa is due to the 202A/376G G6PD A-allele, and association studies have used genotyping as a convenient technique for epidemiological studies. "
04/01/2013 - "A previous study on G6PD deficiency carried out on Tunisian population, led to the finding of seven different mutations with the prevalence of G6PD A- variant. "
08/01/2009 - "Early reports suggested most G6PD deficiency in sub-Saharan Africa was because of the 202A/376G G6PD A- allele, and recent association studies of G6PD deficiency have employed genotyping as a convenient way to determine enzyme status. "
01/01/2009 - "The frequency of G6PD deficiency was similar to other studies performed in Brazil and the finding of a predominant G6PD A(-) variant will help the clinical management of patients with drug-induced haemolysis. "
10/01/2014 - "The G6PD A- mutation (G202A and A376G) does not appear to have a role in G6PD deficiency in a Saudi population."
|4.||Glucose (Dextrose)FDA LinkGeneric
01/01/2011 - "Study 4 found that countries with high rates of glucose-6-phosphate dehydrogenase deficiency (a metabolic disorder related to low glucose levels) also had higher killings rates, both war related and non-war related. "
07/01/2014 - "High frequency of diabetes and impaired fasting glucose in patients with glucose-6-phosphate dehydrogenase deficiency in the Western brazilian Amazon."
05/01/2010 - "G6PD-deficient mice had smaller islets and impaired glucose tolerance compared with control mice, which suggests that G6PD deficiency per se leads to beta-cell dysfunction and death. "
11/01/1978 - "Combined glucose phosphate isomerase and glucose-6-phosphate dehydrogenase deficiency of erythrocytes."
12/03/1964 - "ABNORMAL ORAL GLUCOSE TOLERANCE RESPONSE IN ERYTHROCYTE GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY."
|5.||Vitamin EFDA LinkGeneric
07/01/2008 - "In the present study changes in serum Cu and Zn and role of vitamin E supplementation on these changes were observed in hemolytic anemic patients with G6PD deficiency. "
10/01/1979 - "An examination of the role of vitamin E in glucose-6-phosphate dehydrogenase deficiency."
04/24/1998 - "Treatment includes acidosis correction, high doses of vitamin E and C and avoidance of drugs precipitating hemolytic crises in G6PD deficiency. "
04/28/1983 - "High-dose vitamin E does not decrease the rate of chronic hemolysis in glucose-6-phosphate dehydrogenase deficiency."
08/21/1980 - "Reduced chronic hemolysis during high-dose vitamin E administration in Mediterranean-type glucose-6-phosphate dehydrogenase deficiency."
01/01/2014 - "All studies on neonates and children, except one, recommended a routine screening for G6PD deficiency for this at-risk subpopulation because their immature hepatic function potentially makes them less able to handle any excess bilirubin load. "
07/01/2013 - "Our review of current state of G6PD deficiency screening highlights research gaps and informs specific operational challenges to implement universal newborn G6PD testing concurrent to bilirubin screening in the United States."
06/01/2013 - "Out of the 104 individuals with accompanying bilirubin levels, 41 individuals did not have identifiable UGT1A1 variants that explained their UCH, although glucose-6-phosphate dehydrogenase deficiency and other causes of UCH could not be ruled out. "
08/01/2012 - "The infants with G6PD deficiency had higher bilirubin levels at the time of discharge from the nursery. "
03/01/2005 - "Neonatal bilirubin production-conjugation imbalance: effect of glucose-6-phosphate dehydrogenase deficiency and borderline prematurity."
11/15/2012 - "In 2 clinical trials of antimalarial preparations containing dapsone (4,4'-diaminodiphenylsulfone; 2.5 mg/kg once daily for 3 days), 95 G6PD-deficient hemizygous boys, 24 G6PD-deficient homozygous girls, and 200 girls heterozygous for G6PD deficiency received this agent. "
01/01/2015 - "All male patients were screened for G6PD deficiency before starting dapsone. "
01/01/2008 - "CD+A showed a poor safety profile in individuals with G6PD deficiency most likely as a result of dapsone induced haemolysis. "
05/01/1994 - "Screening for glucose-6-phosphate dehydrogenase deficiency prior to dapsone therapy."
01/01/2009 - "A recent study evaluating the risk of hemolysis in patients with G6PD deficiency found topical dapsone 5% gel to be safe to use in this patient population. "
01/01/2013 - "Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report."
01/01/2014 - "vivax liver stages can be eliminated only by radical treatment with a ≥ seven-day course of an 8-aminoquinoline, with the attendant risk of acute haemolytic anaemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. "
01/01/2012 - "Hypnozoites are only eliminated by using an 8-aminoquinoline (currently only primaquine), which requires compliance with a long regimen as well as care to avoid those at risk of haemolysis due to the common genetic polymorphism, glucose-6-phosphate dehydrogenase deficiency. "
01/01/2014 - "The objective of this systematic review was to assess the risk of adverse effects in people with G6PD deficiency given primaquine or other 8-aminoquinoline (8AQ) as a single dose or short course (less than 7 days). "
01/01/2015 - "Accurate diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is required to avoid the risk of acute hemolysis associated with 8-aminoquinoline treatment. "
05/01/2013 - "The aim of this study was to investigate the prevalence of glucose-6-phospate dehydrogenase (G6PD) deficiency in newborn infants with neonatal hyperbilirubinaemia and to compare the clinical features of G6PD-deficient and G6PD-normal newborn infants. "
10/01/2015 - "Glucose-6-phospahte dehydrogenase deficiency (G6PD) is one of the most common inherited disorders affecting around 400 million people worldwide. "
01/01/2015 - "The elimination effort may further be complicated by possible glucose-6 phosphate dehydrogenase (G6PD) deficiency which would hinder the use of 8-aminoquinolines in the elimination efforts. "
10/01/2013 - "A screen for glucose-6 phosphate dehydrogenase (G6PD) deficiency was negative. "
07/01/2012 - "T, a 28-year-old unmarried male, a diagnosed case of Glucose-6 Phosphate Dehydrogenase (G6PD) deficiency since childhood, presented with 13 years of psychotic illness and disturbed biological functions. "
02/01/2014 - "There was no correlation between G6PD deficiency and umbilical cord blood hemoglobin, white blood count, platelet count, or other hematologic parameters. "
07/01/2011 - "Patients with G6PD deficiency and any known hemoglobin abnormality were excluded. "
11/01/2010 - "At baseline, hemoglobin concentrations were similar among subjects with or without G6PD deficiency. "
04/01/2010 - "Based on enzyme activity less than 1.62 IU/g hemoglobin (Hb), prevalence of G6PD deficiency in three separate measurements was 16.3, 19.1 and 33.3% respectively. "
08/01/2004 - "Total genomic DNAs were isolated from the blood samples of a healthy person and the three persons determined with G6PD deficiency by examining the enzyme activity and hemoglobin ratio. "
|1.||Phototherapy (Light Therapy)
01/01/1989 - "This clinical experience demonstrates that phototherapy is effective and safe for the treatment of non-haemolytic hyperbilirubinaemia or hyperbilirubinaemia associated with G6PD deficiency."
07/01/2013 - "Neonatal testing for G6PD deficiency is not yet routine and the American Academy of Pediatrics recommends testing only in jaundiced newborns who are receiving phototherapy whose family history, ethnicity, or geographic origin suggest risk for the condition, or for infants whose response to phototherapy is poor. "
02/01/2009 - "In the presence of haemolysis or G6PD deficiency, 28% of the infants required re-phototherapy and 8.3% when such factors were absent (p = 0.06). "
09/01/2005 - "One hundred and eight (108) infants were excluded from the nomogram development due to hemolytic diseases (ABO incompatibility 51, G6PD deficiency 34, combined ABO incompatibility and G6PD deficiency 3) and requirement of phototherapy (20). "
01/01/1989 - "Clinical experience with phototherapy in 3,999 infants with non-haemolytic hyperbilirubinaemia and 427 infants with hyperbilirubinaemia associated with G6PD deficiency is presented. "
|3.||Drug Therapy (Chemotherapy)
11/01/2005 - "Reliable field tests for G6PD deficiency are thus needed in chemotherapy studies and their validity has to be assessed. "
11/01/2005 - "As of September 26, 2005, screening for G6PD deficiency should be performed whenever possible prior to chemotherapy administration in patients at risk of developing tumor lysis syndrome."
01/01/2002 - "They must assess patients for G6PD deficiency and signs and symptoms of hypersensitivity reaction before and during chemotherapy or other therapeutic interventions. "
04/01/1992 - "There is some emerging evidence that the genetic burden or survival value associated with G6PD deficiency may be relevant not only in tropical and infectious diseases, but also in their chemotherapy (e.g. "
07/01/2009 - "We present here the case-report of a man with a severe G6PD deficiency revealed after the use of rasburicase (uricolytic drug) during a chemotherapy protocol. "
|4.||Cardiopulmonary Bypass (Heart-Lung Bypass)
08/01/2003 - "Forty-two patients with glucose-6-phosphate dehydrogenase deficiency underwent open heart procedures using cardiopulmonary bypass. "
08/01/2003 - "The purpose of this study was to determine whether the damaging effects of cardiopulmonary bypass, ischemia, and reperfusion would be more pronounced in patients with glucose-6-phosphate dehydrogenase deficiency undergoing cardiac surgery. "
08/01/2003 - "Impaired oxygenation and increased hemolysis after cardiopulmonary bypass in patients with glucose-6-phosphate dehydrogenase deficiency."
10/01/2014 - "The following were found to be statistically significant transfusion predictors (score given): cerebrovascular disease (4), use of aspirin or clopidogril within 7 days of surgery (3), non-elective surgery (2), haematocrit <35% (2), glucose-6-phosphate dehydrogenase (G6PD) deficiency (2), use of cardiopulmonary bypass (2), age > 60 years (1), diabetes mellitus (1) and male gender (-2). "
11/01/2015 - "The factors most frequently associated with neonatal hyperbilirubinemia (in approximately 10% of all studies) were ABO and Rhesus incompatibilities, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, prematurity/low birth weight, infection, birth trauma, and drug-induced labor. "