Glucose Oxidase

An enzyme of the oxidoreductase class that catalyzes the conversion of beta-D-glucose and oxygen to D-glucono-1,5-lactone and peroxide. It is a flavoprotein, highly specific for beta-D-glucose. The enzyme is produced by Penicillium notatum and other fungi and has antibacterial activity in the presence of glucose and oxygen. It is used to estimate glucose concentration in blood or urine samples through the formation of colored dyes by the hydrogen peroxide produced in the reaction. (From Enzyme Nomenclature, 1992) EC 1.1.3.4.

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Networked: 530 relevant articles (18 outcomes, 44 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Huang, Peng: 9 articles (05/2022 - 01/2017)
2.	Lin, Jing: 8 articles (05/2022 - 08/2018)
3.	Zhang, Xian-Zheng: 7 articles (01/2022 - 01/2017)
4.	Li, Na: 5 articles (06/2022 - 11/2018)
5.	Pan, Wei: 5 articles (06/2022 - 11/2018)
6.	Tang, Bo: 5 articles (06/2022 - 11/2018)
7.	Fu, Lian-Hua: 5 articles (12/2021 - 08/2018)
8.	Zhang, Lu: 5 articles (05/2019 - 01/2017)
9.	Liu, Yi: 4 articles (03/2022 - 01/2017)
10.	Liu, Jie: 4 articles (01/2022 - 12/2019)

Related Diseases

1.	Neoplasms (Cancer) 02/10/2022 - "Since glucose oxidase can supply excess H2O2 for RCT to produce ˙OH on one hand, but efficiently cut off the energy supply of tumor cells via ST, on the other hand, our nanosheets exhibit superior tumor therapeutic efficacy to any single treatment benefiting from the cascade and synergy effects between RCT and ST." 12/01/2023 - "Firstly, glucose oxidase (GOx) and Fe3+ loaded in UPGPF nanoreactors are used to directly face the problems of insufficient H2O2 level in tumor tissue and low Fenton reaction efficiency. " 10/01/2023 - "Glucose oxidase (GOD) has a wide range of applications in biosensing and cancer treatment as a result of its unique biocatalytic properties. " 03/01/2021 - "• Glucose oxidase has potential application in cancer treatment." 01/01/2020 - "Cutting off the energy supply by glucose oxidase (GOx) to starve cancer cells has been a feasible and efficient oncotherapy strategy. "
2.	Starvation 01/01/2020 - "Herein, glucose oxidase (GOx) functionalized ancient pigment nanosheets (SrCuSi4 O10 , SC) for programmable near-infrared II (NIR-II) photothermal-enhanced starvation primed CDT is developed. " 06/14/2022 - "The nanoreactor could inhibit autophagy to enhance the glucose oxidase (GOx)-mediated starvation therapy. " 01/01/2022 - "Recently, glucose oxidase (GOx) was reported to be co-delivered with Fenton agent for synergistic starvation therapy (ST) and CDT. " 01/01/2020 - "Programmable NIR-II Photothermal-Enhanced Starvation-Primed Chemodynamic Therapy using Glucose Oxidase-Functionalized Ancient Pigment Nanosheets." 01/01/2020 - "Glucose oxidase (GOx)-mediated starvation circumvents the energy supply for tumor growth, which has been proved as a potent tumor treatment modality. "
3.	Wounds and Injuries (Trauma) 03/01/2009 - "Clinical experience with a glucose oxidase-containing dressing on recalcitrant wounds." 02/01/2005 - "We used a tissue printing procedure with our antibody to determine if larvae secrete glucose oxidase directly at the feeding or wound sites. " 01/01/1972 - "[Antibacterial action of microcide glucose oxidase on the microflora of burn wounds in an experiment]." 05/01/2012 - "Glucose oxidase incorporated collagen matrices for dermal wound repair in diabetic rat models: a biochemical study." 12/12/2022 - "Glucose Oxidase-Integrated Metal-Polyphenolic Network as a Microenvironment-Activated Cascade Nanozyme for Hyperglycemic Wound Disinfection."
4.	Impetigo (Impetigo Contagiosa) 11/01/1994 - "In conclusion, Microcid cream has been documented as a topical alternative to fusidic acid in the treatment of impetigo." 11/01/1994 - "In total, 256 patients with bacteriologically verified impetigo contagiosa were included in three double-blind, parallel group, randomized, multi-centre trials, where the efficacy of hydrogen peroxide cream (Microcid) was compared with that of fusidic acid cream/gel (Fucidin). "
5.	Breast Neoplasms (Breast Cancer) 10/01/2023 - "Glucose oxidase virus-based nanoreactors for smart breast cancer therapy." 06/01/2015 - "Optimizing the design and in vitro evaluation of bioreactive glucose oxidase-microspheres for enhanced cytotoxicity against multidrug resistant breast cancer cells." 10/01/2022 - "Here, dual inhibition on the metabolic plasticity by Glucose oxidase and Telaglenastat loaded liposome (Lip@GOx&Tel) were studied for intervening metabolic pathway on energy and material against breast cancer. " 01/01/2022 - "Liposomal Glucose Oxidase for Enhanced Photothermal Therapy and Photodynamic Therapy against Breast Tumors." 11/01/2009 - "Treatment of MCF-7 human breast cancer cells with glucose oxidase (GO, 0.1 un/ml) induced transient phosphorylation of serine 118 and serine 167. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Enzymes
3.	Hydrogels
4.	Peroxidase (Myeloperoxidase)
5.	Hydrogen Peroxide (Hydroperoxide)
6.	Lactoperoxidase
7.	manganese dioxide
8.	Fusidic Acid (Fucithalmic)
9.	gluconic acid (gluconate)
10.	Hydroxyl Radical

Related Therapies and Procedures

1.	Therapeutics
2.	Photothermal Therapy
3.	Electrodes (Electrode)
4.	Nanospheres
5.	Phototherapy (Light Therapy)