Glomus Jugulare Tumor

A paraganglioma involving the glomus jugulare, a microscopic collection of chemoreceptor tissue in the adventitia of the bulb of the jugular vein. It may cause paralysis of the vocal cords, attacks of dizziness, blackouts, and nystagmus. It is not resectable but radiation therapy is effective. It regresses slowly, but permanent control is regularly achieved. (From Dorland, 27th ed; Stedman, 25th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1603-4)

Also Known As:

Networked: 86 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Paraganglioma (Paragangliomas)
3.	Carcinoid Tumor (Carcinoid)
4.	Cranial Nerve Injuries
5.	Wounds and Injuries (Trauma)

Experts

1.	Maciunas, Robert J: 3 articles (08/2009 - 11/2005)
2.	Megerian, Cliff A: 3 articles (08/2009 - 11/2005)
3.	Al-Mefty, Ossama: 2 articles (01/2022 - 10/2021)
4.	Ibn Essayed, Walid: 2 articles (01/2022 - 10/2021)
5.	Beyzadeoglu, Murat: 2 articles (01/2015 - 03/2014)
6.	Dincoglan, Ferrat: 2 articles (01/2015 - 03/2014)
7.	Sager, Omer: 2 articles (01/2015 - 03/2014)
8.	Einstein, Douglas B: 2 articles (08/2009 - 11/2005)
9.	Miller, Jonathan P: 2 articles (08/2009 - 01/2009)
10.	Adler, John R: 2 articles (01/2007 - 06/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Glomus Jugulare Tumor:

1.	Explosive Agents (Explosives)IBA 01/01/1980 - "A patient with a long history of explosive diarrhea, facial flushing, and violent headaches, the symptom of carcinoid syndrome, was cured after removal of his large glomus jugulare tumor. "
2.	Hormones (Hormone)IBA 10/13/2021 - "Paragangliomas (PGLs) are benign hypervascular tumors that can develop in head and neck at different locations, primarily in the carotid bifurcation, jugular bulb, tympanic plexus, and vagal ganglia.1 Different gene mutations have been linked to the familial inherited forms, which can represent approximately 30% of all PGLs.1,2 These are classified into 5 different clinical syndromes: PGL 1 to 5.1 These patients have increased risk for synchronous and metachronous lesions requiring an extensive work-up for hormone secretion and other associated neoplasms, as well as attentive follow-up for lifelong management.1,3 Surgical resection is the best treatment option as it can be curative when the resection is total.2-4 Preservation of the lower cranial nerve function is central to the management of head and neck PGLs, given the gravity of bilateral injuries.3 Irradiation therapy should be considered if the risk for bilateral lower cranial nerve injuries is high.5 Surgically, intrabulbar resection with preservation of the medial wall of the jugular bulb protects the lower cranial nerve function.3 Other technical finesses, including maintaining the facial nerve in its bony fallopian canal (facial bridge), avoiding carotid artery sacrifice, preservation of the ear canal, and preoperative embolization, contributed markedly to outcome improvement.2,3 We report a case of a 34-yr-old male with PGL 3 with a left glomus jugulare tumor that recurred and a right carotid body tumor. "
3.	ethyleneIBA 02/01/2014 - "The authors of this study describe their experience with cranial neuropathy following transarterial embolization of glomus jugulare tumors using ethylene vinyl alcohol (Onyx, eV3 Inc.). "
4.	CatecholaminesIBA 08/01/2014 - "We describe our perioperative management for catecholamine-secreting glomus jugulare tumor. " 08/01/2014 - "To treat patients with a catecholamine-secreting glomus jugulare tumor, perioperative management is important. " 08/01/2014 - "Perioperative management of catecholamine-secreting glomus jugulare tumors." 12/01/2013 - "Secretory glomus jugulare tumors are often resected surgically to control the systemic effects of the catecholamines they produce. " 12/01/2013 - "Successful management of a catecholamine-secreting glomus jugulare tumor with radiosurgery alone."
5.	Norepinephrine (Noradrenaline)FDA LinkGeneric 08/01/1975 - "Noradrenaline-secreting glomus jugulare tumor with cyclic change of blood pressure." 07/01/1971 - "Norepinephrine in a glomus jugulare tumor. " 01/01/1996 - "[Noradrenaline secreting glomus jugulare tumor (intracranial pheochromocytoma)]." 06/01/1995 - "Therefore, the tumor was classified as a noradrenaline-secreting glomus jugulare tumor fed by the carotid artery. " 06/01/1995 - "Intracranial pheochromocytoma--a case of noradrenaline-secreting glomus jugulare tumor."
6.	CholesterolIBA 01/01/1992 - "This procedure is to be used for lesions falling under the three following categories: glomus jugulare tumors, infralabyrinthine cholesteatomas, and cholesterol cysts of the temporal bone. " 10/01/2004 - "Of the 31 patients with causative lesions on MRI there were 24 vestibular schwannomas, 2 glomus jugulare tumors, 2 ectatic basilar arteries with brainstem compression, 1 petrous apex cholesterol granuloma, 1 case of possible demyelinating disease, and 1 parietal lobe mass. " 09/01/2013 - "We report the unique finding of a petrous apex cholesterol granuloma associated with a paraganglioma, also known as a glomus jugulare tumor, in a 52-year-old woman who presented to our department with pulsatile tinnitus, hearing loss, aural fullness, and disequilibrium. " 01/01/1989 - "Our present material included 9 cholesteatomas, 1 cholesterol cyst, 3 primary epidermoid carcinomas, 2 metastatic neoplasms, 1 glomus jugulare tumor and 4 facial neurinomas. " 01/01/2006 - "Primary tumors include glomus jugulare tumors, schwannomas, meningiomas and peripheral primitive neuroectodermal tumors, while secondary tumors comprise chordomas, chondrosarcomas, chondroblastomas, giant-cell tumors, cholesterol granulomas, giant cholesterol cyst, endolymphatic sac tumors, reactive myofibroblastic tumors, temporal bone carcinomas and metastases. "
7.	Dopamine (Intropin)FDA LinkGeneric 08/01/1984 - "Three cases are reported, including the first documented case of a dopamine secreting glomus jugulare tumor. " 03/01/1998 - "Depression, palpitations, and unilateral pulsatile tinnitus due to a dopamine-secreting glomus jugulare tumor."
8.	Anesthetics (Anesthetic Agents)IBA 07/01/1983 - "Glomus jugulare tumors--origin, pathology, and anesthetic considerations." 08/01/2014 - "Preoperative pharmacologic stabilization and peri- and postoperative anesthetic management are essential for the treatment of a catecholamine-secreting glomus jugulare tumor. "
9.	Vanilmandelic Acid (Vanillylmandelic Acid)IBA 05/01/1988 - "The second patient, a 29-year-old hypertensive male, with a glomus jugulare tumor, had increased vanillylmandelic-acid excretion. "
10.	Radioisotopes (Radionuclides)IBA 06/01/1983 - "The radionuclide angiogram proved safer than contrast angiography and more reliable than clinical examination; it therefore appears to be the method of choice as the primary screening test in patients with suspected carotid-body and glomus-jugulare tumors."

Therapies and Procedures

1.	Radiotherapy 04/01/1992 - "Radiation therapy is an effective treatment for glomus jugulare tumor with minimal late progression of disease in adequately treated patients and no significant long-term complications." 07/01/2023 - "The trend of practice pattern and impact on health care utilization for surgery and radiation therapy (RT) in patients with glomus jugulare tumors (GJTs) is not well defined. " 07/01/2023 - "Trends and Impact of Treatment Modalities (Surgery and Radiation Therapy) on Health Care Utilization in Patients With Glomus Jugulare Tumors (GJTs): An Inverse Probability of Treatment Weight Analysis." 03/01/2014 - "Treatment strategies for glomus jugulare tumors include surgery, preoperative embolization followed by surgical resection, conventionally fractionated external beam radiotherapy, radiosurgery in the form of stereotactic radiosurgery or fractionated stereotactic radiation therapy, and combinations of these modalities. " 01/01/2012 - "[First experience of CyberKnife stereotactic radiotherapy for glomus jugulare tumors]."
2.	Therapeutics 01/01/2013 - "The radiosurgery is a safe and effective therapy for patients with glomus jugulare tumor. " 09/01/2004 - "[Diagnosis and therapy of glomus tympanicum and glomus jugulare tumors]." 11/01/1985 - "Thirty-six patients with glomus jugulare tumors have been managed over a 13-year period using various combinations of skull base surgery and irradiation therapy. " 06/01/1984 - "[Surgical therapy of glomus jugulare tumors]." 01/01/1973 - "Long-term results of therapy of glomus jugulare tumors."
3.	Particle Accelerators 06/01/2003 - "The efficacy of linear accelerator stereotactic radiosurgery in treating glomus jugulare tumors." 03/01/2014 - "In the present study, we evaluate the use of linear accelerator (LINAC)-based stereotactic radiosurgery in the management of glomus jugulare tumors and report our 15-year single center experience. " 03/01/2014 - "Evaluation of linear accelerator-based stereotactic radiosurgery in the management of glomus jugulare tumors."
4.	Mastoidectomy 04/01/1992 - "Inferior mastoidectomy-hypotympanic approach for surgical removal of glomus jugulare tumors: an anatomical and radiologic study emphasizing distances between critical structures."
5.	Catheters 11/01/1979 - "Preoperative percutaneous transfemoral catheter embolization of feeding vessels in glomus jugulare tumors, followed by immediate application of standard surgical techniques, presents the treatment of choice, allowing meticulous microsurgery with virtually complete hemostasis. " 08/01/1973 - "Transfemoral catheter embolization: a method of treatment of glomus jugulare tumors."