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Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal)

A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
Also Known As:
Glomerulosclerosis, Focal; Glomerulosclerosis, Focal Segmental; Hyalinosis, Segmental; Segmental Glomerular Hyalinosis; Focal Glomerulosclerosis; Focal Sclerosing Glomerulonephritides; Focal Sclerosing Glomerulonephritis; Glomerular Hyalinosis, Segmental; Glomerulonephritides, Focal Sclerosing; Sclerosing Glomerulonephritides, Focal; Sclerosing Glomerulonephritis, Focal; Segmental Glomerulosclerosis, Focal; Segmental Hyalinosis; Glomerulonephritis, Focal Sclerosing; Hyalinosis, Segmental Glomerular
Networked: 1587 relevant articles (77 outcomes, 122 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Nephrotic Syndrome (Syndrome, Nephrotic)
2. Proteinuria
3. Membranous Glomerulonephritis (Membranous Nephropathy)
4. Glomerulonephritis
5. IGA Glomerulonephritis (IGA Nephropathy)

Experts

1. Kopp, Jeffrey B: 21 articles (04/2015 - 02/2006)
2. Reiser, Jochen: 19 articles (12/2015 - 07/2005)
3. Wei, Changli: 15 articles (12/2015 - 07/2005)
4. Trachtman, Howard: 15 articles (11/2015 - 10/2004)
5. Ghiggeri, Gian Marco: 15 articles (09/2014 - 02/2003)
6. Bagga, Arvind: 11 articles (03/2014 - 04/2003)
7. Wetzels, Jack F M: 10 articles (01/2015 - 07/2002)
8. Hattori, Motoshi: 9 articles (09/2014 - 12/2003)
9. Caridi, Gianluca: 9 articles (05/2014 - 02/2003)
10. Freedman, Barry I: 8 articles (01/2016 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Focal Segmental Glomerulosclerosis:
1. Cyclosporine (Ciclosporin)FDA LinkGeneric
2. Idiopathic minimal change nephrotic syndromeIBA
3. Prednisone (Sone)FDA LinkGeneric
4. Cyclophosphamide (Cytoxan)FDA LinkGeneric
5. Tacrolimus (Prograf)FDA LinkGeneric
6. MethylprednisoloneFDA LinkGeneric
7. Prednisolone (Predate)FDA LinkGeneric
8. SteroidsIBA
9. rituximab (Mabthera)FDA Link
10. CreatinineIBA

Therapies and Procedures

1. Plasmapheresis
2. Kidney Transplantation
3. Transplantation (Transplant Recipients)
4. Transplants (Transplant)
5. Homologous Transplantation (Allograft)