|1.||Kupfahl, Claudio: 4 articles (09/2011 - 10/2006)|
|2.||Kontoyiannis, Dimitrios P: 4 articles (02/2008 - 01/2005)|
|3.||Hof, Herbert: 3 articles (10/2009 - 10/2006)|
|4.||Komanduri, Krishna V: 3 articles (10/2007 - 01/2005)|
|5.||Waring, Paul: 3 articles (04/2005 - 08/2002)|
|6.||Bhatnagar, Ira: 2 articles (01/2015 - 01/2014)|
|7.||Pardo, Julian: 2 articles (05/2012 - 09/2007)|
|8.||Müllbacher, Arno: 2 articles (05/2012 - 09/2007)|
|9.||Lass-Flörl, Cornelia: 2 articles (09/2011 - 04/2008)|
|10.||Heinekamp, Thorsten: 2 articles (08/2011 - 10/2006)|
01/01/2015 - "Under the light of obtained results, the present study holds immense promise for the biomedical implication of the fungal metabolite, Gliotoxin in medicine for treating various clinical cases of renal fibrosis."
01/01/2015 - "Gliotoxin from Aspergillus fumigatus reverses epithelial to mesenchymal transition: implications in renal fibrosis."
07/01/2008 - "In contrast, C1-3-targeted gliotoxin stimulated a 5-fold increase in non-parenchymal cell apoptosis, depleted liver myofibroblasts by 60%, did not affect the number of monocytes/macrophages and significantly reduced fibrosis severity. "
07/01/2008 - "Injection of free gliotoxin stimulated a 2-fold increase in non-parenchymal cell apoptosis and depleted liver myofibroblasts by 30% and monocytes/macrophages by 50% but had no effect on fibrosis severity in the sustained injury model employed. "
08/01/2003 - "In conclusion, gliotoxin reduces hepatic fibrosis, an effect accompanied by reduction of the numbers of activated hepatic stellate cells in the liver."
07/01/2006 - "In trinitrobenzene sulfonic acid colitis, gliotoxin administration significantly improved the clinical and histopathological symptoms. "
12/01/2000 - "On day 7, gliotoxin treatment significantly improved various indices of colitis, including colonic cytokine levels. "
07/01/2006 - "In this report, the authors investigated the mechanism whereby gliotoxin has anti-inflammatory properties in vitro and in trinitrobenzene sulfonic acid-induced colitis. "
05/01/2002 - "Gliotoxin-treated rats also had partially normalized biochemical indices of colitis, such as colonic cytokine levels. "
07/01/2006 - "Notably, gliotoxin also induced HO-1 in the colonic mucosa and zinc protoporphyrin IX reversed the protective effects of gliotoxin in trinitrobenzene sulfonic acid colitis. "
07/01/2006 - "The current results also demonstrate that gliotoxin may be an effective agent for the treatment of diseases characterized by mucosal inflammation."
06/01/2005 - "The preferential death by necrosis for epithelial cells (CHSE-214) and by apoptosis for macrophages (RTS11) could be a beneficial host response to gliotoxin-producing fungi, leading respectively to the development and then resolution of inflammation."
04/01/2000 - "Here we examined the effects of gliotoxin, a fungal metabolite known to inhibit NF-kappaB activity, on cytokine production by a mouse cell system in vitro and on intestinal inflammation and NF-kappaB activation in vivo. "
08/15/2008 - "Therefore, gliotoxin, blocking inflammation pathway and enhancing irradiation-induced apoptosis, is a promising agent to increase the radiotherapy of tumor cells."
04/01/2000 - "In vivo, gliotoxin treatment of mice was begun on day 3 of 5% DSS application dissolved in the drinking water and continued until day 8. Gliotoxin treatment dose-dependently down-regulated colonic inflammation as assessed histologically and in parallel there was a suppression of colonic TNF-alpha and IL-1alpha mRNA expression on day 8 as analysed by semiquantitative reverse transcriptase-polymerase chain reaction (P < 0.01). "
|5.||Demyelinating Diseases (Demyelinating Disease)
10/01/2003 - "The results of this study therefore indicate that both direct infusion and systemic delivery of rhGGF-2 do not alter remyelination in a nonimmune, gliotoxin model of demyelination. "
10/01/2003 - "Using a gliotoxin model of demyelination we were therefore able to ascertain the in vivo effect of rhGGF-2 following local CNS delivery in a model that is not confounded by the concurrent presence of an immune-mediated process. "
10/01/2003 - "If this enhanced remyelination was due to direct effects of rhGGF-2 on cells of the oligodendrocyte lineage then one would expect rhGGF-2 to induce a similar proremyelinating response in nonimmune, gliotoxin models of demyelination. "
10/01/1999 - "To resolve this issue we have compared remyelination in young and old adult rat CNS following gliotoxin-induced demyelination. "
10/01/1999 - "Remyelination occurs as extensively but more slowly in old rats compared to young rats following gliotoxin-induced CNS demyelination."
|5.||sodium sulfate (sodium bisulfate)
|6.||Glutathione (Reduced Glutathione)
|9.||Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
|2.||Transplantation (Transplant Recipients)
|5.||Heterologous Transplantation (Xenotransplantation)