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Gliosis

The production of a dense fibrous network of neuroglia; includes astrocytosis, which is a proliferation of astrocytes in the area of a degenerative lesion.
Also Known As:
Astrocytoses; Glial Scars; Scar, Glial; Astrocytosis; Astrogliosis; Glial Scar
Networked: 7044 relevant articles (292 outcomes, 554 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Inflammation (Inflammations)
2. Neuroinflammatory Diseases
3. Spinal Cord Injuries (Spinal Cord Injury)
4. Cognitive Dysfunction
5. Gliosis

Experts

1. Won, Moo-Ho: 24 articles (01/2021 - 07/2008)
2. Wang, Wei: 24 articles (01/2021 - 04/2006)
3. O'Callaghan, James P: 22 articles (01/2019 - 04/2002)
4. Reichenbach, Andreas: 20 articles (01/2018 - 02/2002)
5. Masliah, Eliezer: 19 articles (07/2020 - 07/2003)
6. Bringmann, Andreas: 19 articles (04/2017 - 02/2002)
7. Roghani, Mehrdad: 17 articles (02/2022 - 01/2012)
8. Fehlings, Michael G: 17 articles (01/2021 - 02/2002)
9. Pekny, Milos: 17 articles (01/2021 - 06/2005)
10. Doré, Sylvain: 17 articles (10/2020 - 11/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gliosis:
1. CytokinesIBA
2. Proteins (Proteins, Gene)FDA Link
09/01/2000 - "Compared to control mice, by 8 weeks postinjury, the TG mice showed a marked decrease in neuron density and increased gliosis in the hippocampal dentate gyrus and CA3 region as well as in the lateral thalamus, while the few remaining CA3 neurons exhibited cytoskeletal alterations, decreased synaptic protein immunoreactivity, and dissolution of NCIs. "
07/05/2022 - "Such differences in the level of astrocyte Ca2+ signaling can explain the different cytoprotective efficacy of SeNPs, which is expressed in the expression of protective proteins and the activation of reactive astrogliosis. "
12/01/2020 - "Thus, building on earlier results of ameliorated neurobehavioral and cognitive abilities in Spirulina supplemented protein deprived rats, the present study incorporates neurochemical and morphometric analysis of glial cells and neurons and revealed that maternal Spirulina consumption partially prevented the PMN associated neuropathological alterations in terms of attenuated oxidative brain damage, reduced reactive gliosis and apoptotic cell population, improved dendritic branch complexity with few damaged neurons and enhanced mushroom shaped spine density. "
01/01/2007 - "Adenovirus transduction of PrxIII eliminated protein nitration and prevented gliosis caused by direct infusion of ibotenate. "
01/01/2021 - "Our study provides new insight into the mechanisms underlying the beneficial effect of voluntary, sustained running on function of the trisomic brain by identifying the involvement of proteins associated with glutamatergic and GABAergic systems and reduction in reactive astrogliosis."
3. Amyloid (Amyloid Fibrils)IBA
4. Retinaldehyde (Retinal)IBA
5. Peptides (Polypeptides)IBA
6. MelatoninIBA
7. Brain-Derived Neurotrophic Factor (BDNF)IBA
8. Minocycline (Cyclops)FDA LinkGeneric
9. Interleukin-6 (Interleukin 6)IBA
10. Glial Fibrillary Acidic ProteinIBA

Therapies and Procedures

1. Transplantation
2. Therapeutics
07/01/2014 - "Type II CD is more detectable by MRI than other types, partly because of the greater extent of associated gliosis in Type II. Although MRI findings were correlated with the pathological CD type and outcome in this study, the majority of patients (58%) did not have MRI findings that could direct surgical therapy, underscoring the need for improved MRI techniques for detection and for the continued use of multimodal evaluation methods in patient selection."
11/01/2023 - "Several therapies have been developed to improve either glial scar or neuron loss; however, few therapies reach the stage of clinical trials and there are no mainstream therapies for SCI. Exploring the key mechanism of SCI is crucial for finding further treatments. "
01/01/2022 - "This study shows that HTH and MSC therapy improves measures of astrogliosis. "
01/01/2022 - "In addition, downregulation of AQP-4 reduces glial scar formation and the inflammatory response after SCI. There is a consensus from numerous studies that AQP-4 may be a potential target for SCI therapy, which guides the ongoing investigation for molecular therapy of SCI. Here, we review the structure of AQP-4, its expression in normal and damaged spinal cord, and its role in SCI, as well as discuss the theoretical basis for the treatment of SCI."
01/01/2021 - "Overall, studies specifically targeting astrocytes to reduce astrogliosis showed beneficial effects on cognition, which indicates that targeting astrocytes should be included in developing novel therapies for AD."
3. Oral Administration
4. Intranasal Administration
5. Treatment Delay