Open-Angle Glaucoma (Glaucoma, Open Angle)

Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.

Also Known As:

Glaucoma, Open Angle; Pigmentary Glaucoma; Glaucoma, Open-Angle; Chronic Primary Open Angle Glaucoma; Glaucoma, Compensated; Glaucoma, Compensative; Glaucoma, Primary Open Angle; Glaucoma, Secondary Open Angle; Primary Open Angle Glaucoma; Secondary Open Angle Glaucoma; Compensated Glaucoma; Compensative Glaucoma; Open Angle Glaucoma; Open Angle Glaucomas; Open-Angle Glaucomas; Simple Glaucoma; Simplex, Glaucoma; Simplices, Glaucoma; Glaucoma Simplex; Glaucoma, Pigmentary; Glaucoma, Simple

Networked: 6522 relevant articles (515 outcomes, 1213 trials/studies)

Relationship Network

Disease Context: Research Results

Eye Diseases: 3522
- Ocular Hypertension: 3271
  - Glaucoma: 24513
    - Open-Angle Glaucoma: 6522

Related Diseases

1.	Ocular Hypertension (Glaucoma, Suspect)
2.	Glaucoma
3.	Cataract (Cataracts)
4.	Angle-Closure Glaucoma (Glaucoma, Angle Closure)
5.	Exfoliation Syndrome

Experts

1.	Weinreb, Robert N: 54 articles (05/2022 - 03/2004)
2.	Pasquale, Louis R: 53 articles (11/2022 - 08/2003)
3.	Wiggs, Janey L: 41 articles (11/2022 - 01/2002)
4.	Harris, Alon: 36 articles (01/2022 - 03/2002)
5.	Stewart, William C: 35 articles (01/2013 - 05/2002)
6.	Park, Ki Ho: 31 articles (10/2022 - 03/2008)
7.	Siesky, Brent: 27 articles (01/2022 - 03/2002)
8.	Kim, Tae-Woo: 27 articles (04/2021 - 03/2009)
9.	Araie, Makoto: 27 articles (01/2021 - 01/2002)
10.	Ritch, Robert: 26 articles (07/2022 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Open-Angle Glaucoma:

1.	Timolol (Blocadren)FDA LinkGeneric 01/01/1998 - "The efficacy of timoptic depot is assessed in 20 patients with open-angle glaucoma, previously treated with 0.25 and 0.5% timolol. " 10/01/2012 - "The study was undertaken to measure the effects of Beta blocker (Timolol maleate 0.5%) in moderate and advanced stage of primary open angle glaucoma by controlling intra-ocular pressure (IOP) and assessing the visual acuity (VA) and mean sensitivity (MS) of visual field. " 10/01/2009 - "Twenty-five patients with primary open-angle glaucoma (POAG) who were treated with topical timolol 0.5% were included in the study. " 03/01/2009 - "The study included 40 patients (80 eyes) with open angle glaucoma and intraocular pressure (IOP) above 18 mm Hg treated with topical beta blocker (timolol 0.50% twice a day). " 12/01/1996 - "The purpose of this study was to establish whether patients treated with timolol maleate for primary open-angle glaucoma should be reviewed at a specific time of day, within normal clinical hours (9 a.m. "
2.	Latanoprost (Xalatan)FDA Link 07/01/2020 - "In this study, OMDI 0.002% demonstrated a clinically significant reduction in IOP and was well tolerated in patients with primary open-angle glaucoma and OHT who were non-/low responders to latanoprost." 12/01/2018 - "Therapeutic efficacy of latanoprost on primary open angle glaucoma: A protocol for a systematic review of randomized controlled trial." 09/01/2019 - "Materials and methods: New cases of primary open-angle glaucoma treated with topical latanoprost as first-line treatment were enrolled in this prospective study. " 12/01/2018 - "To determine the efficacy of locally produced Latanoprost in reducing the intraocular pressure (IOP) in patients with Primary open-angle glaucoma (POAG). " 12/01/2018 - "Efficacy of locally produced Latanoprost in the control of intraocular pressure in patients with primary open-angle glaucoma."
3.	Travoprost (Travatan)FDA Link 10/01/2014 - "The present study demonstrated the long-term 24-hour efficacy of travoprost for the treatment of primary open-angle glaucoma." 10/01/2014 - "The aim of the study was to evaluate the long-term 24-hour intraocular pressure (IOP) efficacy of travoprost monotherapy in primary open-angle glaucoma patients. " 04/01/2009 - "This study suggests that when both drugs are dosed in the evening the TTFC provides improved intraocular pressure reduction, compared with travoprost, over the 24 h curve and for each individual time point in primary open-angle glaucoma patients." 01/01/2019 - "To study the hypotensive efficacy and safety of Travapress (0.004% travoprost) in patients with primary open-angle glaucoma (POAG). " 06/01/2023 - "Analysing the change in contrast sensitivity post-travoprost treatment in primary open-angle glaucoma patients using Spaeth Richman contrast sensitivity test."
4.	dorzolamide (Trusopt)FDA LinkGeneric 04/01/2002 - "Forty-seven patients with open angle glaucoma were consecutively randomized to dorzolamide versus placebo TID during a 6-week double-masked treatment trial. " 06/01/2018 - "The aim of this prospective crossover study was to evaluate the non-inferiority of PRO-122 (a preservative-free fixed combination) compared with 0.5% timolol + 0.2% brimonidine + 2.0% dorzolamide fixed combination (KOF) by evaluating its efficacy, tolerability and safety in subjects with controlled primary open-angle glaucoma (POAG) previously treated with KOF for at least 2 months. " 10/01/2007 - "To evaluate progression rates with dorzolamide compared with other hypotensive agents in primary open-angle glaucoma. " 04/01/2000 - "Most patients in each group were white, had open-angle glaucoma, and were being treated with a nonselective beta-blocker and dorzolamide. " 06/01/2000 - "In clinical trials, dorzolamide administered 3 times daily was effective in lowering IOP in patients with open-angle glaucoma or ocular hypertension. "
5.	Bimatoprost (Lumigan)FDA Link 11/01/2009 - "Pharmacoeconomic data indicate that bimatoprost is cost effective in the treatment of open-angle glaucoma." 07/01/2009 - "A 12-week study evaluating the efficacy of bimatoprost 0.03% in patients with pseudoexfoliative and open-angle glaucoma." 03/01/2022 - "This longitudinal case-control study included 18 patients with newly diagnosed primary open-angle glaucoma who received topical bimatoprost as a first-line treatment and 20 healthy individuals (age and sex-matched controls). " 06/05/2020 - "Efficacy of bimatoprost for the treatment of primary open-angle glaucoma: A protocol of systematic review and meta-analysis." 01/01/2018 - "[Hypotensive efficacy of bimatoprost in monotherapy of primary open-angle glaucoma]."
6.	Ophthalmic Solutions (Eye Drops)IBA 02/01/1989 - "B antagonists eye drops are most effective for the treatment of chronic open angle glaucoma. " 01/01/2019 - "Thirty-three patients with primary open-angle glaucoma using hypotensive eye drops participated in the study. " 03/01/2015 - "In studies published so far, about 30% decrease of intraocular pressure and a simultaneous 42% reduction of pressure-lowering eyedrops could be achieved in primary and secondary open angle glaucomas. " 05/01/2022 - "To compare the efficacy and safety of brinzolamide1% and timolol0.5% fixed combination eye drops versus dorzolamide2% and timolol0.5% fixed combination eye drops in the treatment of primary open-angle glaucoma. " 05/01/2022 - "Comparative study to assess efficacy and safety of brinzolamide1% and timolol0.5% fixed combination eye drops versus dorzolamide2% and timolol0.5% fixed combination eye drops in management of open-angle glaucoma."
7.	Brimonidine Tartrate (Alphagan)FDA LinkGeneric 05/01/2018 - "Efficacy of three different formulations of brimonidine for control of intraocular pressure in primary open-angle glaucoma: A 6-week randomized trial." 09/01/2001 - "The purpose of this study was to report the acute and chronic effects of brimonidine 0.2% on intraocular pressure (IOP) and pulsatile ocular blood flow (pOBF) in patients with primary open-angle glaucoma (POAG). " 05/01/2018 - "To compare the intraocular pressure (IOP)-lowering efficacy and safety of brimonidine (0.2%), brimonidine purite (0.15%), and brimonidine purite (0.1%) in patients of primary open-angle glaucoma (POAG). " 01/01/2015 - "A 78-year-old male with a history of primary open angle glaucoma presented with symptoms of unilateral blurry vision, irritation, and redness shortly after starting brimonidine exclusively in the right eye. " 04/01/2011 - "Sustained release ocular inserts of brimonidine tartrate for better treatment in open-angle glaucoma."
8.	brinzolamide (Azopt)FDA Link 01/01/2012 - "This study suggests that brinzolamide may be safely added to TTFC therapy to provide further significant reduction in IOP patients with ocular hypertensive or primary open-angle glaucoma." 02/01/2000 - "This study was performed to establish the long-term safety and efficacy of brinzolamide 1.0% two and three times daily for primary open-angle glaucoma and ocular hypertension. " 02/01/2000 - "The long-term safety and efficacy of brinzolamide 1.0% (azopt) in patients with primary open-angle glaucoma or ocular hypertension. " 01/01/2000 - "A multicenter, double-masked, placebo-controlled, parallel trial was conducted to evaluate the optimal intraocular pressure (IOP)-lowering concentration and ocular tolerability of topically administered brinzolamide (0.3%, 1%, 2%, and 3%) in patients with primary, open-angle glaucoma or ocular hypertension. " 09/01/2008 - "Brinzolamide has been introduced to treat ocular hypertension and primary open-angle glaucoma. "
9.	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/01/2021 - "To compare the IOP-lowering efficacy of GATT with mitomycin-C augmented TRAB in patients with uncontrolled open-angle glaucoma. " 03/01/2013 - "To evaluate the safety and preliminary efficacy of intraoperative mitomycin C (MMC) in conjunction with canaloplasty for the treatment of open-angle glaucoma. " 11/01/2019 - "In a prospective monocentric study, 19 eyes with open-angle glaucoma were treated with TE + MMC (mitomycin C). " 08/01/2002 - "To prospectively study and compare the effectiveness and the safety of primary deep sclerectomy with and without the use of mitomycin C in eyes with open-angle glaucoma. " 09/01/2023 - "Ab Externo SIBS Microshunt with Mitomycin C for Open-Angle Glaucoma: Three-Year Results as a Primary Surgical Intervention."
10.	ArgonIBA 06/06/2023 - "Patients with untreated newly diagnosed open-angle glaucoma were treated with three intraocular pressure (IOP)-lowering substances for 1 week and then 360° argon or selective LTP was performed. " 01/01/1985 - "[Hypotensive effect of argon lasertrabeculospasis in the treatment of open-angle glaucoma]." 11/01/1982 - "[Treatment of chronic primary open angle glaucoma with argon laser trabeculo-retraction--preliminary study of 12 eyes]." 01/01/2019 - "[Diode and argon trabeculoplasty in primary open-angle glaucoma treatment]." 01/01/2010 - "Both Argon and Yag lasers are now-a-days commonly used in the treatment of angle-closure and open-angle glaucomas. "

Therapies and Procedures

1.	Trabeculectomy (Trabeculoplasty) 12/01/1988 - "It appears that in cases of primary open angle glaucoma of this severity the risk of delaying operation are significantly greater than those of performing trabeculectomy as the primary treatment." 01/01/2004 - "NPDS appears to be an effective and safe filtering procedure for lowering IOP and could be an alternative to trabeculectomy in open angle glaucoma with the advantage of having fewer complications." 07/01/2023 - "Gonioscopy-assisted transluminal trabeculotomy can be a safe and effective conjunctival-sparing surgery for treating various forms of open-angle glaucoma at 4 years. " 06/21/2023 - "Gonioscopy-assisted transluminal trabeculotomy (GATT) has been used as a safe and effective procedure in the treatment of open angle glaucoma. " 01/01/2023 - "Trabeculectomy using MMC applied by injection is a safe and effective surgical method for the treatment of primary and secondary forms of open-angle glaucoma. "
2.	Lasers (Laser) 01/01/2018 - "The combined laser treatment involving LIE and SLT was effective in treating primary and advanced pigmentary glaucoma. " 01/01/2020 - "Combination of modified CLASS and preventive laser iris management was effective and safe in the long-term treatment of primary open-angle glaucoma patients." 04/01/1983 - "Another use of the laser: a new treatment for open-angle glaucoma." 01/01/2014 - "Despite advances in laser and microsurgical techniques, medical IOP reduction remains the first-line treatment option for the majority of patients with open-angle glaucoma. " 01/01/2020 - "The purpose of this study was to determine the significance of the correlations between blood flow on the optic nerve head (ONH) using the mean blur rate (MBR) determined by laser speckle flowgraphy and the visual field loss determined by perimetry and the structural alterations by optical coherence tomography in eyes solely with open-angle glaucoma. "
3.	Therapeutics 01/01/2023 - "The iStent Infinite Trabecular Micro-Bypass System implanted in patients with open angle glaucoma (OAG) (uncontrolled by prior surgical or medical therapy) was effective in reducing mean diurnal intraocular pressure with a favorable safety profile. " 12/01/1996 - "We studied patients with chronic open-angle glaucoma who had similar intraocular pressures to determine whether surgical or medical therapy is more effective in preventing progressive, long-term, glaucomatous damage. " 11/01/2020 - "The only widely accepted, effective treatment for open-angle glaucoma (OAG) is to reduce the intraocular pressure (IOP), with medical therapy being the typical first-line therapy. " 08/01/1998 - "In eyes with open-angle glaucoma and unsatisfactory IOP control on maximally tolerated medical therapy, DLT and ALT are equally effective in lowering IOP over a 5-year period." 10/01/2016 - "Trabectome surgery is an effective and safe method in early-stage open-angle glaucoma types that cannot be controlled despite maximal medical therapy. "
4.	Stents 07/01/2022 - "Standalone XEN45 Gel Stent implantation is effective in lowering IOP in open-angle glaucoma. " 08/14/2020 - " trabecular microbypass stent implantation was effective in reducing IOP and medication usage in patients with open-angle glaucoma with a low preoperative IOP. " 02/01/2023 - "The aim of this study was to determine the preoperative characteristics influencing hypotensive efficacy of the XEN45 gel stent in patients with open-angle glaucoma at one-year follow-up. " 11/01/2016 - "The purpose of the study was to evaluate the safety and efficacy of the iStent Trabecular Micro-Bypass stent in pseudophakic patients with open-angle glaucoma. " 04/01/2019 - "[XEN® Gel Stent for management of chronic open angle glaucoma: A review of the literature (French translation of the article)]."
5.	Phacoemulsification 11/01/2015 - "The IOP lowering obtained by this combined surgery is significantly greater than that obtained after phacoemulsification alone in open-angle glaucoma. " 12/01/2020 - "PRéCIS:: Regardless of the blood-filling patterns in Schlemm canal (SC) before the trabecular meshwork (TM) ablation, the trabectome surgery, combined with phacoemulsification, is effective for mild to moderate primary open-angle glaucoma patients. " 01/01/2023 - "Although there are limited microstent devices on the market, multiple studies have evaluated the safety and efficacy of iStent® (Glaukos Corp.), iStent Inject® (Glaukos Corp.), and Hydrus® Microstent (Alcon) in the treatment of mild-to-moderate open-angle glaucoma, with and without concurrent phacoemulsification. " 01/01/2023 - "To investigate the efficacy of endotrabeculectomy (ETE) performed either alone or combined with phacoemulsification (phaco) in patients with primary open-angle glaucoma (POAG). " 10/01/2022 - "To assess the safety and efficacy of endocyclophotocoagulation with phacoemulsification (phaco-ECP) in surgically naive, primary open-angle glaucoma (POAG). "