Glafenine

12/01/1988 - "Fifty-one per cent of the nonresponsive patients to paracetamol could benefit from the glafenine treatment and 18 per cent of patients suffering from hip or knee osteoarthritis in this study showed improvement only with glafenine. "

04/01/1980 - "[Glaphenine in the treatment of various neurological pain syndromes]."
07/01/1984 - "Double-blind comparison with standard glaphenine in post-apicoectomy pain (wisdom teeth included)]."
07/01/1993 - "The mean decreases in pain and tenderness on the second and fourth days, in relation to their initial values, were greater in the diclofenac-potassium treated patients than the glafenine treated ones. "
07/01/1993 - "The mean decrease of pain level in diclofenac-potassium group after 1/2 hour was significantly (P < 0.01) greater than that in the glafenine group. "
07/01/1993 - "Diclofenac potassium in the management of dental pain: a multicenter double-blind comparison with glafenine."

09/01/2011 - "Severe liver toxicity and a high incidence of anaphylaxis were reported in patients treated with glafenine, eventually leading to its withdrawal from the market in most countries. "
01/01/1991 - "Glafenine was mentioned as the cause in 36% of all admissions for drug-induced anaphylaxis. "
01/01/1991 - "Glafenine-associated anaphylaxis as a cause of hospital admission in The Netherlands."
10/13/1990 - "Anaphylaxis to glafenine."
06/01/1985 - "The timing of the symptoms in the context of an anaphylactic reaction and their repetition when the same molecule was reintroduced are strong arguments in favour of the pathogenic role of glafenine, even in the absence of biological criteria which are always variable. "

01/01/1983 - "We have been able to study 6 cases of acute poisoning and 5 cases of glafenine renal stones which have shown that several mechanisms are likely to be involved. "
07/01/1974 - "Acute tubulointerstitial nephropathy due to glafenine poisoning. "
12/23/1972 - "[Acute tubulo-interstitial nephropathy caused by glafenine poisoning]."
08/01/1988 - "[Acute renal insufficiency due to intentional glafenine poisoning]."
10/01/1981 - "Recurrent acute renal failure due to nonaccidental poisoning with glafenin in a child."

06/01/1978 - "Leucocyte migration test and hypersensitivity to glafenin."
06/01/1985 - "[Transmural myocardial infarction and Prinzmetal's syndrome in an allergic reaction to glafenine. "
08/01/1984 - "Pulmonary hypersensitivity in a 36-year-old man manifested by fever, abnormal lung auscultation, lung infiltrates and blood eosinophilia had to be ascribed to glafenine, a widely used analgesic drug. "
06/01/1985 - "The authors report the case of a 38 year old man who experienced at two month' interval, hypersensitivity reactions to the ingestion of 200 mg tablets of glafenine, complicated on the first occasion by a transmural anterior wall myocardial infarction as the first manifestation of coronary artery disease and on the second occasion by Prinzmetal angina due to posterior wall ischaemia. "
10/13/2020 - "Exclusion criteria are: Inability to make an informed decision to participate (e.g.: dementia, guardianship); Rockwood Clinical Frailty Scale ≥7; Long QT syndrome; QTc interval > 500 ms; Heart rate <50/min; Kalaemia >5.5 mmol/L or <3.5 mmol/L; Ongoing treatment with piperaquine, halofantrine, dasatinib, nilotinib, hydroxyzine, domperidone, citalopram, escitalopram, potent inhibitors or inducers of cytochrome P450 CYP3A4 isoenzyme, repaglinide, azathioprine, 6-mercaptopurine, theophylline, pyrazinamide, warfarin; Known hypersensitivity to any of the trial drugs or to chloroquine and other 4-aminoquinolines, amodiaquine, mefloquine, glafenine, floctafenine, antrafenine, ARB; Hepatic porphyria; Liver failure (Child-Pugh stage ≥B); Stage 4 or 5 chronic kidney disease (GFR <30 mL/min/1.73 m²); Dialysis; Hypersentivity to lactose; Lactase deficiency; Abnormalities in galactose metabolism; Malabsorption syndrome; Glucose-6-phosphate dehydrogenase deficiency; Symptomatic hyperuricemia; Ileus; Colitis; Enterocolitis; Chronic hepatitis B virus disease. "