Tourette Syndrome (Tourette's Syndrome)

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846 relevant articles (63 outcomes, 128 trials/studies) found for this Disease

Description: A neuropsychological disorder related to alterations in DOPAMINE metabolism and neurotransmission involving frontal-subcortical neuronal circuits. Both multiple motor and one or more vocal tics need to be present with TICS occurring many times a day, nearly daily, over a period of more than one year. The onset is before age 18 and the disturbance is not due to direct physiological effects of a substance or a general medical condition. The disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning. (From DSM-IV, 1994; Neurol Clin 1997 May;15(2):357-79)

Also Known As:

Tourette's Syndrome; Combined Vocal and Multiple Motor Tic Disorder; Gilles de la Tourette Syndrome; Tourette's Disorder; Syndrome, Tourette's; Combined Multiple Motor and Vocal Tic Disorder; Multiple Motor and Vocal Tic Disorder, Combined; Tourette Disease; Tourette Disorder; Tourette's Disease; Tourettes Disease; Tourettes Disorder; Tourettes Syndrome; Gilles de la Tourette's Disease; Tic Disorder, Combined Vocal and Multiple Motor

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3414

Neurodegenerative Diseases: 7363

Nervous System Heredodegenerative Disorders: 24

Tourette Syndrome: 846

Central Nervous System Diseases: 930

Movement Disorders: 1472

Tic Disorders: 155

Tourette Syndrome: 846

Brain Diseases: 1120

Basal Ganglia Diseases: 181

Tourette Syndrome: 846

Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 421

Inborn Genetic Diseases: 549

Nervous System Heredodegenerative Disorders: 24

Tourette Syndrome: 846

Mental Disorders: 1709

Mental Disorders Diagnosed in Childhood

Tic Disorders: 155

Tourette Syndrome: 846

Related Diseases

1.	Tics (Tic)
2.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
3.	Tic Disorders (Tic Disorder)
4.	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive)
5.	Dyskinesias (Dyskinesia)

Experts

1.	Singer, Harvey S: 6 articles (09/2007 - 08/2002)
2.	Leckman, James F: 6 articles (07/2007 - 03/2005)
3.	Müller-Vahl, K R: 5 articles (07/2007 - 03/2000)
4.	Müller-Vahl, Kirsten R: 5 articles (09/2005 - 02/2003)
5.	Robertson, M M: 4 articles (07/2008 - 02/2004)
6.	Visser-Vandewalle, Veerle: 4 articles (04/2008 - 03/2006)
7.	Scahill, Lawrence: 4 articles (07/2007 - 03/2005)
8.	Sandor, Paul: 4 articles (09/2006 - 02/2002)
9.	Hebebrand, Johannes: 4 articles (06/2006 - 05/2004)
10.	Shytle, R D: 4 articles (09/2001 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Tourette Syndrome:

1.	Haloperidol (Haldol)FDA LinkGeneric 10/20/1976 - "Tourette's syndrome patients treated successfully with haloperidol, untreated patients, and healthy controls were studied with tests of temporal discrimination and measures of transmitted information shown previously to be sensitive to brain dysfunction" 08/01/1979 - "Neuroendocrine effects of haloperidol in an adolescent with Gilles de la Tourette's disease and delayed onset of puberty." 08/26/1968 - "Gilles de la Tourette's syndrome: remission with haloperidol." 11/01/1999 - "Six Tourette's syndrome men aged 14-48 years resistant to haloperidol participated in the study" 10/01/1982 - "A prospective clinical and biochemical study on the effects of treatment with haloperidol has been performed in seven patients with Tourette syndrome" Order ALL the reference details at left...
2.	Pimozide (Orap)FDA Link 03/10/1999 - "Short-term versus longer term pimozide therapy in Tourette's syndrome: a preliminary study." 03/01/1984 - "Controlled study of pimozide vs. placebo in Tourette's syndrome." 10/01/1987 - "Significant interindividual variability of pimozide pharmacokinetics was found in both adults and children with Tourette's syndrome" 10/01/1987 - "Mean elimination half-life of pimozide in children was 66 hours compared with 111 hours in adults with Tourette's syndrome" 10/01/1987 - "A comparison of the pharmacokinetics of pimozide was made in children and adults with Tourette's syndrome" Order ALL the reference details at left...
3.	Clonidine (ST 155)FDA LinkGeneric 03/01/1987 - "Clonidine has been suggested to be effective in Gilles de la Tourette's syndrome (GTS), but no double-blind study has ever evaluated its effects using objective measures" 12/01/1980 - "Clonidine ameliorates Gilles de la Tourette syndrome." 01/01/1990 - "Nine patients with mild Tourette's syndrome completed a cross-over, placebo-controlled study of clonidine administered transdermally" 12/01/1986 - "Following an open trial of clonidine hydrochloride (3 to 8 micrograms/kg/day for 12 weeks), we studied the behavioral, cardiovascular, and neurochemical effects of abrupt clonidine withdrawal in seven patients with Tourette's syndrome aged 9 to 13 years" 11/01/1998 - "Conflicting and inconsistent dosing advice for clonidine in Tourette's syndrome." Order ALL the reference details at left...
4.	Nicotine FDA Link 04/01/2004 - "Evidence from pre-clinical infrahuman investigations, open-label clinical trials, and a single controlled trial found acute nicotine treatment potentiated up to 4 weeks neuroleptic-induced reductions of dyskinetic symptoms characterizing Tourette's syndrome (TS)" 10/01/2001 - "Preliminary clinical studies indicate possible therapeutic benefits of nicotine in the treatment of Tourette's syndrome (TS)" 06/01/2005 - "Excitability of motor cortex inhibitory circuits in Tourette syndrome before and after single dose nicotine." 04/01/2004 - "Clinical and attentional effects of acute nicotine treatment in Tourette's syndrome." 10/01/2001 - "Nicotine attenuates DOI-induced head-twitch response in mice: implications for Tourette syndrome." Order ALL the reference details at left...
5.	Risperidone (Risperdal Consta)FDA Link 04/08/2003 - "A placebo-controlled trial of risperidone in Tourette syndrome." 11/01/2002 - "While risperidone is not usually known to induce dysphoria or depression in patients treated for other psychiatric disorders, previous short-term 4- to 12-week trials of risperidone for Tourette's disorder have reported a 2.6% to 30.8% incidence of depression" 02/01/2002 - "A double-blind, placebo-controlled trial was performed to determine the efficacy and tolerability of 8 weeks of treatment with risperidone in the management of 48 adolescent and adult patients with Tourette syndrome" 02/01/2002 - "Risperidone in the treatment of tourette syndrome: a double-blind, placebo-controlled trial." 01/01/1996 - "BACKGROUND: An open-label trial was performed to assess the efficacy and safety of risperidone, a benzisoxazole derivative with potent D2 and 5-HT2 antagonism, for treatment of Tourette's syndrome" Order ALL the reference details at left...
6.	Antipsychotic Agents (Antipsychotics)IBA 01/01/2008 - "Antipsychotics in the treatment of Tourette disorder: a review]" 01/01/2006 - "Tardive Tourette syndrome should not be misdiagnosed as an exacerbation of schizophrenic symptoms responsive to an increase of neuroleptics" 01/01/2001 - "BACKGROUND: The treatment of Tourette's disorder with classical neuroleptics is limited by their side effects" 05/01/1997 - "Over the next few years, intensive research efforts will be required to characterize the effect of the new atypical antipsychotics in patients with Tourette syndrome and related disorders, and to determine which sets of symptoms and which subgroups of patients best respond to particular agents" 03/01/1992 - "At the present time, neuroleptics are indicated for the treatment of acute psychotic states as well as Tourette's syndrome in children and adults" Order ALL the reference details at left...
7.	quetiapine (Seroquel)FDA Link 01/01/2001 - "Controlled studies are needed to determine the efficacy of quetiapine in the treatment of Tourette's syndrome." 01/01/2007 - "We therefore aimed to investigate the efficacy of quetiapine, a newer atypical antipsychotic, in the treatment of children and adolescents with Tourette's syndrome" 07/01/2007 - "Quetiapine in patients with Tourette's disorder: an open-label, flexible-dose study." 01/01/2003 - "OBJECTIVE: The purpose of this study was to investigate the short-term safety and effectiveness of quetiapine in the treatment of children and adolescents with Tourette's disorder" 01/01/2007 - "In this article we describe the clinical response of an 8-year-old boy with the Gilles de la Tourette syndrome (GTS) when treated with quetiapine" Order ALL the reference details at left...
8.	aripiprazole (Abilify)FDA Link 12/01/2006 - "Aripiprazole is effective in the treatment of Tourette's disorder." 10/01/2008 - "Aripiprazole in children and adolescents with Tourette disorder with and without explosive outbursts." 02/15/2008 - "Aripiprazole: a treatment for severe coprolalia in "refractory" Gilles de la Tourette syndrome." 01/07/2008 - "Aripiprazole for the treatment of Tourette's syndrome.]" 06/01/2007 - "CONCLUSIONS: Aripiprazole may be a good pharmacological option for patients with Tourette syndrome." Order ALL the reference details at left...
9.	olanzapine (Zyprexa)FDA Link 01/01/2000 - "The goal of our investigation was to assess the efficacy of olanzapine in patients with Tourette's disorder who were either antipsychotic naive or who did not tolerate and/or did not respond to previous antipsychotic treatments in an open-label pilot study" 04/01/2001 - "BACKGROUND: An open-label trial was performed to explore efficacy and safety of olanzapine, an atypical neuroleptic with diverse receptor activity including both dopamine-2 and serotonin-2A and -2C antagonism, for treatment of Tourette's disorder" 04/01/2001 - "An open-label study of the treatment efficacy of olanzapine for Tourette's disorder." 10/01/2008 - "Effectiveness and tolerability of open label olanzapine in children and adolescents with Tourette syndrome." 07/01/2007 - "Following ten years of continuous olanzapine therapy a 51 years old man developed a Gilles de la Tourette syndrome which disappeared after changing to amisulprid" Order ALL the reference details at left...
10.	Desipramine (Pertofrane)FDA LinkGeneric 09/01/1986 - "A boy with Tourette's syndrome and ADD-like symptoms was treated with desipramine, and all the symptoms improved" 01/01/1995 - "Desipramine showed a statistically significant improvement on a global linear analogue scale, but not on the Hopkins Motor/Vocal Tic Severity Scale, the Tourette Syndrome Severity Scale, or the Yale Global Tic Severity Scale" 11/01/1987 - "Tourette's syndrome with symptoms of attention deficit disorder treated with desipramine." 09/01/1986 - "A case of Tourette's syndrome with symptoms of attention deficit disorder treated with desipramine." 03/01/1993 - "Desipramine treatment of children with attention-deficit hyperactivity disorder and tic disorder or Tourette's syndrome." Order ALL the reference details at left...

Therapies and Procedures

1.	Deep Brain Stimulation 07/15/2008 - "Therapy-refractory Tourette syndrome: beneficial outcome with globus pallidus internus deep brain stimulation." 11/01/2007 - "Prospective randomized double-blind trial of bilateral thalamic deep brain stimulation in adults with Tourette syndrome." 08/01/2007 - "In patients with Tourette's syndrome, the results of the first trials with thalamic and pallidal deep brain stimulation have been very promising" 10/30/2008 - "Papers concerning the use of deep brain stimulation to the thalamus for relief of symptoms of Tourette syndrome have frequently cited a paper by Hassler and Dieckmann, published in 1970" 04/01/2008 - "Deep brain stimulation in Tourette's Syndrome." Order ALL the reference details at left...
2.	Psychosurgery (Lobotomy) 01/01/2004 - "This report describes the use of cingulotomy and subsequent limbic leucotomy in an adolescent boy with Tourette's Disorder for SIB" 01/01/2004 - "Psychosurgery for self-injurious behavior in Tourette's disorder." 05/01/1995 - "Longitudinal evolution of prefrontal leucotomy in Tourette's syndrome." 09/01/1993 - "The metabolic effects of limbic leucotomy in Gilles de la Tourette syndrome." 08/01/1990 - "The treatment of Gilles de la Tourette syndrome by limbic leucotomy." Order ALL the reference details at left...
3.	Relaxation Techniques (Relaxation Technique) 02/01/1998 - "To evaluate the feasibility and efficacy of behavioral relaxation therapy as treatment for Tourette syndrome, 23 patients were recruited from a university-based pediatric Tourette syndrome referral clinic" 02/01/1998 - "Relaxation therapy in Tourette syndrome: a pilot study." 06/01/1989 - "This paper describes an attempt to treat Gilles de la Tourette syndrome (GTS) in a severely mentally handicapped girl, using a cue-controlled relaxation technique" 02/01/1998 - "On the basis of this pilot study, relaxation therapy appears to have a limited role in the treatment of tics in Tourette syndrome." Order ALL the reference details at left...
4.	Pallidotomy 05/01/2005 - "OBJECTIVE: To evaluate the efficacy and safety of unilateral pallidotomy in treating Tourette syndrome (TS)" 05/01/2005 - "CONCLUSIONS: (1) Pallidotomy is proven to be a safe and effective method to treat TS, it provides a significant immediate and short term reduction of tic severity in intractable Tourette' syndrome" Order ALL the reference details at left...
5.	Body Piercing (Piercing, Body) 01/01/2007 - "Improvement in speech dysfluency in Tourette's disorder after tongue piercing." Order ALL the reference details at left...

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