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Gigantism

The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
Also Known As:
Pituitary Gigantism; Gigantism, Pituitary
Networked: 201 relevant articles (6 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Acromegaly
2. Pituitary Neoplasms (Pituitary Adenoma)
3. Adenoma (Adenomas)
4. Stroke (Strokes)
5. Carney Complex

Experts

1. Trivellin, Giampaolo: 3 articles (02/2016 - 01/2012)
2. Ebert, Dieter: 3 articles (04/2015 - 11/2004)
3. Sun, Cheng: 3 articles (01/2014 - 01/2012)
4. Mueller, Rachel Lockridge: 3 articles (01/2014 - 01/2012)
5. Stratakis, Constantine A: 2 articles (02/2016 - 12/2014)
6. Daly, Adrian F: 2 articles (12/2015 - 12/2014)
7. Beckers, Albert: 2 articles (12/2015 - 12/2014)
8. Rostomyan, Liliya: 2 articles (12/2015 - 12/2014)
9. Zatelli, Maria Chiara: 2 articles (12/2014 - 09/2005)
10. Peng, Ying: 2 articles (06/2014 - 08/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gigantism:
1. Growth Hormone (Somatotropin)IBA
2. Octreotide (Sandostatin)FDA LinkGeneric
3. Insulin-Like Growth Factor I (IGF-1)IBA
4. pegvisomantFDA LinkGeneric
5. lanreotide (Somatuline)FDA Link
6. ProlactinIBA
7. Somatotropin Receptors (Growth Hormone Receptor)IBA
8. aryl hydrocarbon receptor-interacting proteinIBA
9. Succinate Dehydrogenase (Fumarate Reductase)IBA
10. OxygenIBA

Therapies and Procedures

1. Hypophysectomy
2. Injections
3. Castration
4. Amputation
5. Radiotherapy