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Giant Lymph Node Hyperplasia (Castleman's Disease)

Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.
Also Known As:
Castleman's Disease; Angiofollicular Lymphoid Hyperplasias; Castleman Tumor; Castlemans Disease; Castlemans Tumor; Hyperplasia, Angiofollicular Lymphoid; Hyperplasias, Angiofollicular Lymphoid; Lymphoid Hyperplasia, Angiofollicular; Lymphoid Hyperplasias, Angiofollicular; Tumor, Castleman's; Angiofollicular Lymphoid Hyperplasia; Castleman Disease; Castleman's Tumor; GLNH; Hyperplasia, Giant Lymph Node; Lymph Node Hyperplasia, Giant
Networked: 535 relevant articles (50 outcomes, 20 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Rheumatoid Arthritis
2. Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
3. Kaposi Sarcoma (Kaposi's Sarcoma)
4. Anemia
5. Crohn Disease (Crohn's Disease)

Experts

1. Kishimoto, Tadamitsu: 11 articles (01/2015 - 01/2002)
2. Nishimoto, Norihiro: 10 articles (05/2014 - 01/2002)
3. Dispenzieri, Angela: 9 articles (10/2015 - 06/2004)
4. Kurzrock, Razelle: 8 articles (01/2016 - 09/2007)
5. Yarchoan, Robert: 8 articles (01/2015 - 03/2007)
6. Tanaka, Toshio: 7 articles (03/2015 - 12/2011)
7. Little, Richard F: 7 articles (12/2014 - 03/2007)
8. Bower, Mark: 7 articles (01/2014 - 09/2004)
9. van Rhee, Frits: 6 articles (10/2015 - 08/2010)
10. Aleman, Karen: 6 articles (12/2014 - 03/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Giant Lymph Node Hyperplasia:
1. tocilizumabFDA Link
2. rituximab (Mabthera)FDA Link
3. Interleukin-6 (Interleukin 6)IBA
4. Interleukin-6 Receptors (Interleukin 6 Receptor)IBA
5. Thalidomide (Thalomid)FDA Link
6. bortezomib (Velcade)FDA Link
7. AntibodiesIBA
8. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
9. IronIBA
10. lenalidomide (CC 5013)FDA Link

Therapies and Procedures

1. Radiotherapy
2. Drug Therapy (Chemotherapy)
3. Combination Drug Therapy (Combination Chemotherapy)
4. Highly Active Antiretroviral Therapy (HAART)
5. Aftercare (After-Treatment)