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Giant Cell Tumors (Giant Cell Tumor)

Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.
Also Known As:
Giant Cell Tumor; Cell Tumor, Giant; Cell Tumors, Giant; Tumor, Giant Cell; Tumors, Giant Cell
Networked: 630 relevant articles (16 outcomes, 46 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Neoplasm Metastasis (Metastasis)
3. Pigmented Villonodular Synovitis
4. Osteosarcoma (Osteogenic Sarcoma)
5. Malignant Fibrous Histiocytoma

Experts

1. Wunder, Jay S: 5 articles (05/2013 - 03/2003)
2. Nielsen, Torsten O: 5 articles (04/2010 - 06/2007)
3. Xiao, Jianru: 4 articles (09/2015 - 10/2011)
4. van de Rijn, Matt: 4 articles (07/2015 - 06/2007)
5. West, Robert B: 4 articles (04/2010 - 06/2007)
6. Mankin, Henry J: 4 articles (10/2005 - 07/2002)
7. Yin, Huabin: 3 articles (09/2015 - 09/2014)
8. Xu, Wei: 3 articles (09/2015 - 09/2014)
9. Aponte-Tinao, Luis A: 3 articles (09/2015 - 08/2006)
10. Yang, Xinghai: 3 articles (08/2015 - 10/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Giant Cell Tumors:
1. denosumabFDA Link
2. tartrate-resistant acid phosphatase (TSAP)IBA
3. Doxorubicin (Adriamycin)FDA LinkGeneric
4. Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
5. HemosiderinIBA
6. RANK LigandIBA
7. Protons (Proton)IBA
02/01/2008 - "In vivo proton spectroscopy of giant cell tumor of the bone."
06/01/2006 - "This report reviews two cases of patients presenting with aggressive giant cell tumors that were irradiated by a combination of photons and protons. "
08/01/1982 - "Serial proton nuclear magnetic resonance (NMR) images of distal upper extremities were obtained in four healthy volunteers and four patients with giant cell tumor of the distal radius. "
05/01/2002 - "This report reviews the treatment of four pediatric patients presenting with aggressive giant cell tumor, using fractionated and combined, conformal proton and photon radiation therapy at Massachusetts General Hospital and Harvard Cyclotron Laboratory. "
02/01/1995 - "Important advances discussed over this period include: establishment of sarcoma teams in major oncology centers; staging systems for both soft tissue and osseous sarcomas; demonstration of genetic determinants in the development of, at least, some of the sarcomas; the revolutionary change in quality of diagnostic imaging by the introduction of CT and MRI; use of immunohistochemistry in diagnostic pathology; the drastic gains in survival of patients with osteogenic sarcoma, Ewing's sarcoma and rhabdomyosarcoma due to the efficacy of multi-drug and multi-cycle chemotherapy protocols; major advances in surgical techniques which have made limb salvage practical; cell lines derived from human sarcomas have been shown to have in vitro radiation sensitivity comparable to that of cell lines from epithelial tumors; the combination of conservative surgery and moderate doses of radiation yields local control and survival results equivalent to that of radical surgery with a much improved functional and cosmetic outcome; intra-operative electron beam radiation therapy improves the outcome of patients with retroperitoneal sarcomas when given after grossly complete resection combined with external beam radiation therapy (pre- or postoperatively); radiation is a highly effective alternative to extensive surgery for desmoid tumors; local control of giant cell tumors by modern radiation techniques is approximately 80% and the incidence of radiation induced tumors at 10 years is approximately 3%; to decrease the incidence of radiation induced sarcoma, resection has replaced radiation in the management of selected patients with primary Ewing's sarcoma when the response to chemotherapy has been excellent and the morbidity/functional decrement consequent upon the surgery judged reasonable; proton beam radiation therapy has been accepted as being superior to conventional external beam radiation therapy for chondrosarcoma and chordoma of the skull base; and attempts to utilize brachytherapy for sarcomas of the spine/sacrum appear to offer promise. "
8. DiphosphonatesIBA
9. Dihydrotachysterol (AT 10)IBA
11/01/2009 - "We report a case of a multiply recurrent aggressive giant cell tumor diagnosed at 10 months of age with extensive involvement of the maxillae and mandibles unresponsive to multiple therapeutic modalities. "
03/15/2002 - "Of the patients with benign tumors, 1 patient (giant cell tumor) had local failure at 10 months. "
02/01/1995 - "Important advances discussed over this period include: establishment of sarcoma teams in major oncology centers; staging systems for both soft tissue and osseous sarcomas; demonstration of genetic determinants in the development of, at least, some of the sarcomas; the revolutionary change in quality of diagnostic imaging by the introduction of CT and MRI; use of immunohistochemistry in diagnostic pathology; the drastic gains in survival of patients with osteogenic sarcoma, Ewing's sarcoma and rhabdomyosarcoma due to the efficacy of multi-drug and multi-cycle chemotherapy protocols; major advances in surgical techniques which have made limb salvage practical; cell lines derived from human sarcomas have been shown to have in vitro radiation sensitivity comparable to that of cell lines from epithelial tumors; the combination of conservative surgery and moderate doses of radiation yields local control and survival results equivalent to that of radical surgery with a much improved functional and cosmetic outcome; intra-operative electron beam radiation therapy improves the outcome of patients with retroperitoneal sarcomas when given after grossly complete resection combined with external beam radiation therapy (pre- or postoperatively); radiation is a highly effective alternative to extensive surgery for desmoid tumors; local control of giant cell tumors by modern radiation techniques is approximately 80% and the incidence of radiation induced tumors at 10 years is approximately 3%; to decrease the incidence of radiation induced sarcoma, resection has replaced radiation in the management of selected patients with primary Ewing's sarcoma when the response to chemotherapy has been excellent and the morbidity/functional decrement consequent upon the surgery judged reasonable; proton beam radiation therapy has been accepted as being superior to conventional external beam radiation therapy for chondrosarcoma and chordoma of the skull base; and attempts to utilize brachytherapy for sarcomas of the spine/sacrum appear to offer promise. "
10. imatinib (Gleevec)FDA Link

Therapies and Procedures

1. Radiotherapy
2. Drug Therapy (Chemotherapy)
3. Curettage
4. Transplants (Transplant)
5. Arthrodesis