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Gardner Syndrome

A variant of ADENOMATOUS POLYPOSIS COLI caused by mutation in the APC gene (GENES, APC) on CHROMOSOME 5. It is characterized by not only the presence of multiple colonic polyposis but also extracolonic ADENOMATOUS POLYPS in the UPPER GASTROINTESTINAL TRACT; the EYE; the SKIN; the SKULL; and the FACIAL BONES; as well as malignancy in organs other than the GI tract.
Also Known As:
Gardner's Syndrome; Gardner Syndromes; Gardner's Syndromes; Gardners Syndrome; Syndrome, Gardner; Syndrome, Gardner's; Syndromes, Gardner; Syndromes, Gardner's
Networked: 152 relevant articles (4 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neoplasms (Cancer)
2. Adenoma (Adenomas)
3. Aggressive Fibromatosis (Desmoid)
4. Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)
5. Polyps

Experts

1. Hartmann, Wolfgang: 2 articles (01/2022 - 01/2013)
2. Wardelmann, Eva: 2 articles (01/2022 - 01/2013)
3. Lauro, A: 2 articles (01/2014 - 11/2013)
4. Pinna, A D: 2 articles (01/2014 - 11/2013)
5. Pironi, L: 2 articles (01/2014 - 11/2013)
6. Zanfi, C: 2 articles (01/2014 - 11/2013)
7. Kozarek, Richard A: 2 articles (10/2012 - 04/2007)
8. Lin, Otto S: 2 articles (10/2012 - 04/2007)
9. Hamilton, David: 1 article (05/2022)
10. Smith, Clara: 1 article (05/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gardner Syndrome:
1. Sulindac (Copal)FDA LinkGeneric
2. Doxorubicin (Adriamycin)FDA LinkGeneric
3. Dacarbazine (DIC)FDA LinkGeneric
4. DiamondIBA
5. Retinaldehyde (Retinal)IBA
6. DNA (Deoxyribonucleic Acid)IBA
09/01/2007 - "Suspected patients should have a complete workup for Gardner's syndrome, including lower gastrointestinal tract endoscopy, barium enema imaging, and DNA testing."
05/01/2017 - "retinoblastoma syndrome/RB1 and Li-Fraumeni syndrome/TP53, Gardner syndrome/APC), energy metabolism (enchondromatosis/IDH1/2), complex signaling cascades (multiple hereditary exostoses/EXT1/2) and DNA integrity (Rothmund-Thomson/RECQL4, Werner/WRN and Bloom syndromes/BLM). "
08/01/1995 - "DNA-based diagnostic testing is now available for hereditary breast-ovarian cancer, for hereditary nonpolyposis colon cancer, for Gardner syndrome (familial polyposis coli), for neurofibromatosis, multiple endocrine neoplasia, and for Von-Hippel Lindau disease. "
10/01/1984 - "The incidence of in vitro tetraploidy during logarithmic growth in dermal fibroblast monolayer cultures from normals without a family cancer history and affected with heritable colon cancer syndromes, familial polyposis coli (FPC) and the Gardner syndrome (GS) was assayed by (1) examination of metaphase preparations for percentage of tetraploids (4N nuclei); (2) determination of [3H]thymidine incorporation (average cpm/cell); and (3) measurement by flow cytophotometry of the percentage of cells with greater than 4C DNA content. "
06/01/1990 - "Exposure of fibroblasts derived from keloid tissues, desmoid and dermal tissue from individuals with Gardner's syndrome (GS) to dexamethasone resulted in the suppression of protein kinase C (PKC) activity and [3H]thymidine incorporation into DNA, and a 20-fold induction of glutamine synthetase activity. "
7. CateninsIBA
8. Estrogens (Estrogen)FDA Link
9. beta CateninIBA
10. ThymidineIBA

Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Endoscopes
4. Colectomy
5. Restorative Proctocolectomy