gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)

An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.

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Networked: 3223 relevant articles (74 outcomes, 256 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pompella, Alfonso: 36 articles (01/2022 - 02/2002)
2.	Paolicchi, Aldo: 32 articles (01/2022 - 02/2002)
3.	Franzini, Maria: 20 articles (01/2022 - 12/2004)
4.	Corti, Alessandro: 19 articles (01/2022 - 12/2004)
5.	Emdin, Michele: 18 articles (01/2022 - 04/2002)
6.	Carr, Brian I: 17 articles (06/2020 - 01/2007)
7.	Kunutsor, Setor K: 12 articles (01/2018 - 02/2014)
8.	Zhou, Jian: 11 articles (10/2022 - 11/2005)
9.	Fan, Jia: 11 articles (07/2020 - 09/2003)
10.	Wang, Jian-She: 10 articles (01/2022 - 07/2010)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "The purpose of this study is to investigate the predictive value of GLR (gamma-glutamyl transpeptidase to lymphocyte count ratio) in single HCC with a tumor size (TS) ≤ 5 cm. A retrospective analysis was performed on 272 patients with TS ≤ 5 cm who underwent radical resection. " 06/01/2018 - "In this study, ALP is correlated to γ-glutamyl transpeptidase (GGT; p = 0.002) and the tumor location in the liver (p = 0.007), and increased levels of ALP had poor effects on overall survival (p = 0.006) and progression-free survival (p = 0.022). " 01/01/2012 - "Although experimental studies have shown that gamma-glutamyltransferase (GGT) has a role in tumor progression, epidemiologic evidence for a relationship between GGT and cancer incidence is limited. " 09/01/2011 - "Gamma-glutamyltransferase and risk of cancer in a cohort of 545,460 persons - the Swedish AMORIS study." 10/01/1992 - "In our study, in contrast with the previous report, all animals that had survived some initial toxicity were found to have developed hepatic tumors or hyperplastic gamma-glutamyltransferase-positive foci a year later. "
2.	Liver Diseases (Liver Disease) 07/01/2006 - "However, patients included in these studies belong to a heterogeneous population, which may not represent true cases of ICP since some reports include patients diagnosed in the first trimester of pregnancy, with elevated serum levels of gamma-glutamyl transpeptidase and clear evidence of chronic liver disease. " 03/01/1985 - "This study shows that serum gamma-glutamyl transpeptidase is persistently elevated in patients with clinically obvious liver injury, but only in 22% of chronic alcoholics without significant liver disease." 09/01/1974 - "A histochemical study on the activity of gamma-glutamyl transpeptidase in liver disease." 07/15/1972 - "[Study of gamma-glutamyl transpeptidase in liver diseases]." 12/01/2021 - "Gamma-glutamyltransferase (GGT), a marker of liver disease, has been shown to be associated with increased risk of diabetes and relative insulin secretion deficiency. "
3.	Cholestasis 02/01/2022 - "This study aimed to detect variations in exons 14, 15, and 24 of the ABCB11 gene in patients with suspected PFIC2 among a group of Egyptian infants and children with normal gamma-glutamyl transpeptidase (GGT) cholestasis. " 01/01/2022 - "In this study, we analyzed the genetic data of cholestasis patients with no obvious extrahepatic involvement but with an unexplained high level of gamma-glutamyl transpeptidase (GGT). " 11/01/2021 - "This study sought second pathogenic variants in ATP8B1 by whole-genome sequencing (WGS) in four unrelated low γ-glutamyl transpeptidase cholestasis patients in whom clinical suspicion of PFIC1 was high and gene-panel or Sanger sequencing had identified only one pathogenic variant in ATP8B1. " 06/14/2023 - "By reverse phenotyping, we identified a de novo variant c.1883G > A in FAM111B of a case with high glutamyl transpeptidase (GGT) cholestasis. " 02/01/2021 - "Biallelic variants in the USP53 gene have recently been reported to segregate with normal gamma glutamyltransferase (GGT) cholestasis. "
4.	Body Weight (Weight, Body) 01/01/2020 - "Covariate analysis led to the selection of γ-glutamyl transpeptidase on apparent oral clearance and body weight on apparent volume of distribution as covariates. " 10/24/1997 - "Earlier work also showed that after ten daily doses the AFB dose-response relationship with gamma-glutamyl transpeptidase (GGT) positive preneoplastic foci measured at 3 months was sublinear, with a threshold at a dose of about 150 micrograms/kg body weight/day. " 06/01/1989 - "The rats subjected to repeated heavy exercises (swimming with the load equal to 10% of body weight) had an increased activity of gamma-glutamyl transpeptidase in the urine. " 01/01/1995 - "One group of animals was killed by decapitation on the 120th day and testicular functions like sperm count in testis and epididymis, testicular glutamyl transpeptidase activity and Leydig cell count as well as body weight were noted. " 07/01/1987 - "This study was conducted to follow as a function of time the activity of gamma-glutamyltransferase in the various membranes of rat liver cells after a single dose of phenobarbital (PB) (75 mg kg-1 body weight). "
5.	Fibrosis (Cirrhosis) 09/01/2016 - "Fibrosis 4 and APRI were less accurate in excluding significant stiffness; however, performance of models significantly improved with γ-glutamyl transpeptidase (GGT) and body mass index (BMI) (area under receiver operating characteristic curve, 0.81; 95% confidence interval, .76-.87). " 09/01/2003 - "The demographical parameters of the study population, the indices of alcohol consumption: erythrocyte median corpuscular volume (MCV), gamma-glutamyl transpeptidase (GGT), the histological characteristics were noted and a statistical analysis was performed in order to determine the factors independently associated with severe fibrosis and with severe steatosis. " 08/01/2022 - "Gamma-glutamyl transpeptidase (GGT) levels (72.9 vs 51.1 IU/L; P = 0.23) and ΔGGT (+6.0% vs -6.9%; P = 0.06) were higher in the advanced fibrosis group. " 12/01/2021 - "In training cohort, we developed a novel fibrosis index, GAPI, using γ-glutamyl transpeptidase (GGT), age, platelet, and international normalized ratio (INR) results. " 01/01/2021 - "Of the patients, 35 (55.6%) had CLI on their initial episode of TCMR; those patients with CLI were significantly associated with the type of immunosuppression treatment (P = 0.03), severity of TCMR (P < 0.001), higher gamma-glutamyltransferase (P = 0.01), and advanced fibrosis (P = 0.03). "

Related Drugs and Biologics

1.	Alkaline Phosphatase
2.	Alanine Transaminase (SGPT)
3.	Bilirubin
4.	Aspartate Aminotransferases (Aspartate Transaminase)
5.	Enzymes
6.	Cholesterol
7.	Glutathione (Reduced Glutathione)
8.	Bile Acids and Salts (Bile Acids)
9.	Antioxidants
10.	Creatinine

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Liver Transplantation
4.	Neoadjuvant Therapy
5.	Drug Therapy (Chemotherapy)