gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)

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1657 relevant articles (29 outcomes, 110 trials/studies) found for this Bio-Agent

Description: An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.

Also Known As:

gamma-Glutamyl Transpeptidase; Transpeptidase, Glutamyl; Transpeptidase, gamma-Glutamyl; gamma Glutamyl Transpeptidase; gamma Glutamyltransferase; GGTP; Glutamyl Transpeptidase; gammaglutamyltransferase; (5-L-Glutamyl)-peptide:amino-acid 5-glutamyltransferase

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1

Enzymes: 24378

Transferases: 3171

Acyltransferases: 11

Aminoacyltransferases

gamma-Glutamyltransferase: 1657

gamma-glutamyltransferase related enzyme

Experts

1.	Paolicchi, Aldo: 11 articles (03/2008 - 02/2002)
2.	Pompella, Alfonso: 11 articles (03/2008 - 02/2002)
3.	Huseby, Nils-Erik: 5 articles (12/2007 - 03/2002)
4.	Jacobs, David R: 5 articles (06/2007 - 08/2003)
5.	Emdin, Michele: 5 articles (05/2006 - 04/2002)
6.	Ruttmann, Elfriede: 4 articles (10/2008 - 10/2005)
7.	Diem, Günter: 4 articles (10/2008 - 10/2005)
8.	Concin, Hans: 4 articles (10/2008 - 10/2005)
9.	Ulmer, Hanno: 4 articles (10/2008 - 10/2005)
10.	Jousilahti, Pekka: 4 articles (07/2008 - 04/2002)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1992 - "In our study, in contrast with the previous report, all animals that had survived some initial toxicity were found to have developed hepatic tumors or hyperplastic gamma-glutamyltransferase-positive foci a year later" 02/01/1986 - "Histochemical studies of tumors revealed a marked increase in the phenotypic expression of the oncofetal enzyme, gamma-glutamyl transpeptidase (GGT) in the tumors of treated rats." 07/01/1985 - "This study was undertaken to determine whether gamma-glutamyl transpeptidase (GGT) histochemical activity is expressed during the development of human oral, pharyngeal, and laryngeal squamous neoplasms" 10/15/2008 - "Prospective study of the association of gamma-glutamyltransferase with cancer incidence in women." 05/15/2008 - "Association of gamma-glutamyltransferase and risk of cancer incidence in men: a prospective study." Order ALL the reference details at left...
2.	Cholestasis 11/01/2003 - "Obstetric cholestasis with elevated gamma glutamyl transpeptidase: incidence, presentation and treatment." 11/01/2001 - "Although all patients had severe cholestasis, serum gamma glutamyltransferase values were normal" 07/01/2000 - "Longitudinal analysis of the treated group showed that cholestasis and cytolisis parameters constantly decreased and that gamma-glutamyl transpeptidase was significantly lower compared to baseline values at the 4th month of therapy" 03/01/2000 - "PFIC types 1 and 2 are characterized by cholestasis and a low to normal serum gamma-glutamyltransferase (GGT) activity, whereas in PFIC type 3, the serum GGT activity is elevated" 01/01/1997 - "Our data corroborate Muller et al.'s suggestion that fetuses with cholestasis might demonstrate lower GGTP values in their amniotic fluid at a given stage of gestation" Order ALL the reference details at left...
3.	Liver Diseases (Liver Disease) 07/01/2006 - "However, patients included in these studies belong to a heterogeneous population, which may not represent true cases of ICP since some reports include patients diagnosed in the first trimester of pregnancy, with elevated serum levels of gamma-glutamyl transpeptidase and clear evidence of chronic liver disease" 03/01/1985 - "This study shows that serum gamma-glutamyl transpeptidase is persistently elevated in patients with clinically obvious liver injury, but only in 22% of chronic alcoholics without significant liver disease." 09/01/1974 - "A histochemical study on the activity of gamma-glutamyl transpeptidase in liver disease." 07/15/1972 - "Study of gamma-glutamyl transpeptidase in liver diseases]" 01/01/2007 - "Routine testing for serum GGTP levels to assess liver disease induced by hepatotropic viruses or other agents in dialysis population is suggested." Order ALL the reference details at left...
4.	Body Weight (Weight, Body) 04/01/2006 - "For example, gamma-glutamyl transpeptidase activity was decreased from 20.3 +/- 6.7 mmol/min/mg protein to almost normal levels (2.8 +/- 0.9) by 750 mg/kg body weight of the extract" 12/01/2005 - "Significant reductions in body weight, BMI, waist circumference, blood pressure, TC, LDL-C, non-HDL-C, triglyceride and SUA levels, as well as gamma-glutamyl transpeptidase activity and HOMA index were observed in all treatment groups" 10/24/1997 - "Earlier work also showed that after ten daily doses the AFB dose-response relationship with gamma-glutamyl transpeptidase (GGT) positive preneoplastic foci measured at 3 months was sublinear, with a threshold at a dose of about 150 micrograms/kg body weight/day" 06/01/1989 - "The rats subjected to repeated heavy exercises (swimming with the load equal to 10% of body weight) had an increased activity of gamma-glutamyl transpeptidase in the urine" 01/01/1995 - "One group of animals was killed by decapitation on the 120th day and testicular functions like sperm count in testis and epididymis, testicular glutamyl transpeptidase activity and Leydig cell count as well as body weight were noted" Order ALL the reference details at left...
5.	Pruritus (Itching) 08/01/2008 - "Individuals with inborn errors of bile acid synthesis generally present with the hallmark features of normal or low serum bile acid concentrations, normal gamma-glutamyl transpeptidase concentrations and the absence of pruritus" 10/01/2003 - "BACKGROUND AND AIMS: Progressive familial intrahepatic cholestasis (PFIC) is characterized by pruritus, intrahepatic cholestasis, low serum gamma-glutamyltransferase levels, and characteristic "Byler bile" on electron microscopy" 01/01/1998 - "CONCLUSIONS: These data suggest that although UDCA therapy improves pruritus and results in a reduction in ALT and gamma-glutamyl transpeptidase, UDCA therapy did not improve quantitative measures of hepatic function in children with intrahepatic cholestasis." 01/01/2003 - "To detect PBC early, young and middle-aged women with unexplained weakness or skin pruritus should undergo a comprehensive examination including measurements of GGTP, AP, AMA, IgM, morphological investigation of liver tissue" 03/01/1996 - "Within nine days, severe pruritus developed, alkaline phosphatase and gamma-glutamyltransferase increased" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Alkaline Phosphatase
2.	Bilirubin
3.	Glutathione (Reduced Glutathione)
4.	Alanine Transaminase (SGPT)
5.	Aspartate Aminotransferases (Aspartate Transaminase)
6.	Cholesterol
7.	Enzymes
8.	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)
9.	Bile Acids and Salts (Bile Acids)
10.	Oxidoreductases

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Liver Transplantation
4.	Transplants (Transplant)
5.	Hepatectomy

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