gamma-Glutamylcyclotransferase

An enzyme that catalyzes the synthesis of pyroglutamate from a gamma-glutamyl-amino acid, also releasing the free amino acid. The enzyme acts on derivatives of glutamate, 2-aminobutyrate, alanine and glycine. The enzyme has been proposed to have a role in a gamma-glutamyl cycle for amino acid transport into cells in the intestines. EC 2.3.2.4.

Also Known As:

gamma-Glutamylamine Cyclotransferase; Cyclotransferase, gamma-Glutamylamine; gamma Glutamylamine Cyclotransferase; gamma Glutamylcyclotransferase; (5-L-Glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Aminoacyltransferases
        gamma-Glutamylcyclotransferase: 8
        human CHAC1 protein
        human CHAC2 protein
        human GGCT protein
        mouse Chac1 protein

Experts

1.	Ii, Hiromi: 4 articles (01/2019 - 01/2015)
2.	Kageyama, Susumu: 4 articles (01/2019 - 01/2015)
3.	Kawauchi, Akihiro: 4 articles (01/2019 - 01/2015)
4.	Chano, Tokuhiro: 3 articles (01/2019 - 01/2018)
5.	Nakata, Susumu: 3 articles (01/2019 - 01/2018)
6.	Taniguchi, Keiko: 3 articles (01/2019 - 01/2018)
7.	Yoshiki, Tatsuhiro: 3 articles (01/2018 - 01/2015)
8.	Ashihara, Eishi: 2 articles (01/2018 - 01/2018)
9.	Matsumura, Kengo: 2 articles (01/2018 - 01/2018)
10.	Dong, Zhaoliang: 1 article (09/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Previous studies show that gamma-glutamylcyclotransferase (GGCT) is expressed at high levels in various cancer tissues and that its knockdown inhibits MCF7 cancer cell growth via upregulation of p21WAF1/CIP1 (p21). " 01/01/2019 - "Inhibition of gamma-glutamylcyclotransferase (GGCT), which is highly expressed in various cancer tissues, exerts anticancer effects both in vitro and in vivo. " 01/01/2019 - "Depletion of gamma-glutamylcyclotransferase inhibits cancer cell growth by activating the AMPK-FOXO3a-p21 axis." 01/01/2018 - "Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence." 01/01/2015 - "Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and Treatment."
2.	Stomach Neoplasms (Stomach Cancer) 12/01/2016 - "Gamma glutamylcyclotransferase (GGCT) has been proved to be involved in various cancers, but the biological function of GGCT in gastric cancer is still largely unknown. " 01/01/2019 - "To screen the novel biomarkers for gastric cancer and to determine the values of glutaminase 1 (GLS1) and gamma-glutamylcyclotransferase (GGCT) for detecting gastric cancer. "
3.	Osteosarcoma (Osteogenic Sarcoma) 09/28/2021 - "Gamma-glutamylcyclotransferase (GGCT) can promote the progression of osteosarcoma (OS). " 09/28/2021 - "miR-877 inhibits the proliferation, migration, and invasion of osteosarcoma cells by targeting gamma-glutamylcyclotransferase."
4.	Glioma (Gliomas) 03/18/2016 - "Gamma-glutamylcyclotransferase promotes the growth of human glioma cells by activating Notch-Akt signaling."
5.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2018 - "Gamma-glutamylcyclotransferase (GGCT) was originally identified as a protein highly expressed in bladder cancer tissues by proteomic analysis, and its higher expression in a variety of cancers compared to normal tissues have been shown. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Proteins (Proteins, Gene)
3.	Glutaminase