|1.||Gambling (Pathological Gambling)
|2.||Impulse Control Disorders (Kleptomania)
|3.||Parkinson Disease (Parkinson's Disease)
|4.||Alcoholism (Alcohol Abuse)
|5.||Cocaine-Related Disorders (Cocaine Addiction)
|1.||Potenza, Marc N: 44 articles (01/2016 - 01/2003)|
|2.||Grant, Jon E: 39 articles (11/2015 - 01/2002)|
|3.||Kim, Suck Won: 23 articles (08/2014 - 01/2002)|
|4.||Petry, Nancy M: 16 articles (08/2013 - 06/2002)|
|5.||Hollander, Eric: 15 articles (12/2014 - 07/2002)|
|6.||Odlaug, Brian L: 13 articles (09/2015 - 09/2007)|
|7.||Blanco, Carlos: 10 articles (04/2015 - 03/2002)|
|8.||Chamberlain, Samuel R: 9 articles (10/2015 - 12/2010)|
|9.||Zack, Martin: 9 articles (09/2015 - 01/2004)|
|10.||Clark, Luke: 9 articles (09/2015 - 05/2010)|
|1.||Naltrexone (ReVia)FDA LinkGeneric
09/01/2002 - "Naltrexone, or augmentation of naltrexone with an SSRI, appears to be most effective in relieving gambling symptoms."
05/01/2008 - "Subjects assigned to naltrexone had significantly greater reductions in PG-YBOCS total scores (p = .0094), gambling urges (p = .0053), and gambling behavior (p = .0134) compared to subjects assigned to placebo. "
05/01/2008 - "Subjects assigned to naltrexone also had greater improvement in overall gambling severity (reflected in the CGI-S scores) (p = .0080) and in psychosocial functioning (p = .0177) than subjects assigned to placebo. "
09/01/2001 - "The present findings provide evidence that naltrexone may be effective in the treatment of pathological gambling disorder. "
06/01/2001 - "Results suggest that naltrexone is effective in reducing the symptoms of pathologic gambling. "
|2.||Fluvoxamine (Luvox)FDA LinkGeneric
05/01/2000 - "Fluvoxamine resulted in a significantly greater percent improvement in overall gambling severity on the PG Clinical Global Impression (PG-CGI) scale. "
03/01/2002 - "Fluvoxamine may be a useful treatment for certain subgroups of patients with pathological gambling. "
03/01/2002 - "The objective of this study was to evaluate the efficacy of fluvoxamine in the treatment of pathological gambling. "
06/30/2009 - "Changes of functional MRI findings in a patient whose pathological gambling improved with fluvoxamine."
03/01/2002 - "A pilot placebo-controlled study of fluvoxamine for pathological gambling."
03/01/2011 - "Differences in the patterns of co-occurring disorders between subsyndromal levels of gambling in Hispanic and white respondents indicate the importance of considering ethnicity/race-related factors related to subthreshold levels of gambling in developing improved mental health prevention and treatment strategies."
08/01/2015 - "This study's primary and secondary aims were to 1) examine the relationship of personality traits to co-occurring lifetime (current/past) alcohol dependence status, while 2) accounting for differences in gambling characteristics and co-occurring psychiatric disorders among problem/pathological gamblers recruited from the community. "
12/01/2014 - "The goal of the present study was to provide a comprehensive and nuanced portrait of the relation between personality and gambling by taking a multivariate approach to the co-use of multiple gambling activities and employing a broad inventory of potentially relevant personality dimensions. "
03/01/2013 - "To apply social network analysis (SNA) to investigate whether frequency and severity of gambling problems were associated with different network characteristics among friends, family and co-workers is an innovative way to look at relationships among individuals; the current study was the first, to our knowledge, to apply SNA to gambling behaviors. "
09/01/2012 - "Few studies have directly examined the relation between reward processing and gambling severity while concurrently examining the effects of co-occurring negative affect in this at risk population. "
|4.||Dopamine (Intropin)FDA LinkGeneric
08/01/2014 - "These findings suggest that pharmacologic targeting of the dopamine-1 receptor may be beneficial in gambling behavior. "
12/01/2015 - "Several studies have investigated the neurobiological background of this phenomenon and it was found that activation in the mesolimbic-mesocortical dopamine system during a gambling decision correlates with loss aversion. "
09/01/2015 - "The aim of the present study is to triangulate dopamine, reversal learning, and pathological gambling. "
01/01/2013 - "Studies of reward prediction and reward uncertainty show a sustained dopamine response toward stimuli with maximum uncertainty, which may explain the continued dopamine release and gambling despite losses in gambling disorder. "
01/01/2013 - "This article focuses on three hypotheses of dopamine dysfunctions in gambling disorder, which appear to be "fallacies," i.e., have not been supported in a series of positron emission tomography (PET) studies. "
|5.||Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
01/01/2005 - "Selective serotonin reuptake inhibitors may be effective for some patients with pathological gambling, but those with comorbid conditions, such as bipolar spectrum disorders, may relapse during treatment. "
01/01/2005 - "Several open-label and double-blind studies have suggested that selective serotonin reuptake inhibitors may be useful in the treatment of pathological gambling. "
01/01/2000 - "The link between serotonergic dysfunction and the pathophysiology of impulsivity is discussed, and studies that examine the efficacy of various selective serotonin reuptake inhibitors and other alternatives in the treatment of impulsive disorders such as pathological gambling, sexual addictions and borderline personality disorder are presented."
05/01/2009 - "Serotonin reuptake inhibitors (SRIs) have shown benefits as first-line, short-term treatments for body dysmorphic disorder, hypochondriasis, onychophagia, and psychogenic excoriation, with some benefits in trichotillomania, pathological gambling, and compulsive buying. "
12/01/2006 - "Recent studies have demonstrated that pathological gambling patients respond well to treatment with selective serotonin reuptake inhibitors, mood stabilizers and opioid antagonists. "
12/01/2014 - "The case presented also corroborates previous evidence on the efficacy of lithium in patients with pathological gambling and comorbid bipolar spectrum conditions and euphoric temperament. "
08/01/2005 - "After receiving 10 weeks of lithium treatment, the patient showed improvement in both gambling behavior and affective instability. "
12/01/2014 - "Pathological gambling treated with lithium: the role of assessing temperament."
01/01/2005 - "Sustained-released lithium may be an effective treatment in reducing both gambling behavior and affective instability in pathological gamblers with bipolar spectrum disorder. "
01/01/2005 - "Does sustained-release lithium reduce impulsive gambling and affective instability versus placebo in pathological gamblers with bipolar spectrum disorders?"
|7.||Serotonin (5 Hydroxytryptamine)IBA
03/01/2012 - "The present study revealed that (1) brain 5-HT depletion leads to poor decision-making and to gambling proneness; (2) the relationship between these two traits, shown in the control group, was disrupted in 5-HT depleted rats. "
03/01/2012 - "Psycho-genetic studies have revealed a role for the brain serotonin system in gambling proneness and poor decision-making. "
08/01/2013 - "Using pharmacological fMRI, we manipulated the availability of serotonin in healthy volunteers while performing a gambling task. "
03/01/2013 - "Family-based association analysis of serotonin genes in pathological gambling disorder: evidence of vulnerability risk in the 5HT-2A receptor gene."
03/01/2012 - "We assessed whether manipulation of brain serotonin levels in rats affected performance in operant-based tasks for decision-making and gambling proneness. "
|8.||Bupropion (Wellbutrin)FDA LinkGeneric
04/01/2007 - "We tested the efficacy of bupropion in the treatment of persons with pathological gambling (PG). "
04/01/2007 - "Bupropion in the treatment of pathological gambling: a randomized, double-blind, placebo-controlled, flexible-dose study."
02/01/2004 - "An open-label trial of bupropion in the treatment of pathologic gambling."
03/01/2007 - "Bupropion therapy for pathological gambling."
12/01/2005 - "Sustained-release bupropion versus naltrexone in the treatment of pathological gambling: a preliminary blind-rater study."
|9.||Lithium Carbonate (Eskalith)FDA LinkGeneric
01/01/2005 - "Pathological gambling patients with bipolar spectrum disorders significantly improved while taking sustained-release lithium carbonate compared to placebo on total pathological gambling scores on the Yale-Brown Obsessive Compulsive Scale, including both thoughts/urges and behavior, as well as on the Clinical Global Impression severity of pathological gambling scale. "
01/01/2005 - "Forty pathological gambling patients with bipolar spectrum disorders entered a 10-week randomized, double-blind, placebo-controlled treatment study of sustained-release lithium carbonate. "
07/01/2002 - "Findings from the present study suggest the efficacy of both lithium carbonate and valproate in the treatment of pathological gambling. "
04/01/1980 - "Lithium and lady luck; use of lithium carbonate in compulsive gambling."
|10.||Levodopa (L Dopa)FDA LinkGeneric
05/01/2010 - "Additional variables independently associated with ICDs were levodopa use, living in the United States, younger age, being unmarried, current cigarette smoking, and a family history of gambling problems. "
04/15/2010 - "As expected, however, an individual's DRD4 polymorphism accounted for variation in gambling behavior after the administration of L-DOPA. "
04/15/2010 - "Without considering genetic information, L-DOPA administration did not lead to an increase in gambling propensity compared with placebo. "
04/15/2010 - "Subjects played a gambling task 60 minutes after L-DOPA administration. "
06/01/2005 - "Apathy and reward sensitivity (Apathy Scale, Stimulus-Reward Learning, Reversal, Extinction, and Gambling tasks) were assessed in 18 PD patients treated by bilateral STN stimulation ("on" and "off" conditions) compared with 23 matched patients undergoing long term treatment with levodopa ("on" and "off" conditions). "
04/01/2015 - "Motivational interviewing was associated with significant reduction in gambling frequency up to a year after treatment delivery. "
03/01/2015 - "After treatment, self-reported gambling symptoms, depression, anxiety, and impulsiveness were all improved, and all the participants reported satisfaction with the therapy. "
02/01/2012 - "This study evaluated probability and delay discounting in treatment-seeking pathological gamblers and their association with gambling treatment outcomes during and after treatment. "
03/01/2015 - "The model is based on the book "Pathological gambling - with self-help manual" by Dr Mladenovic and Dr Lazetic, and has been designed in the form of a program that lasts 10 weeks in the intensive phase, and then continues for two years in the form of "extended treatment" ("After care"). "
12/01/2011 - "Although entry into gambling treatment was temporally associated with reductions in alcohol use in this retrospective analysis, a substantial portion of the sample exhibited at-risk drinking after treatment entry, suggesting that interventions targeting reductions in alcohol use may be useful for this population."
|2.||Drug Therapy (Chemotherapy)
03/01/2004 - "Although pharmacotherapy is often effective for pathological gambling, little is known about how it affects older populations. "
12/01/2014 - "Future clinical trials on pathological gambling pharmacotherapy should include temperament assessment to evaluate its influence on different outcomes."
02/01/2014 - "A systematic review of the 18 double-blind, placebo-controlled pharmacotherapy studies conducted for the treatment of pathological gambling was conducted. "
01/01/2010 - "This article reviews the literature on effective treatments in adults with pathological gambling, describes the safety data for the use of these drugs in adolescents, and provides a rationale for future studies to investigate the efficacy and tolerability of pharmacotherapies for pathological gambling in adolescents."
01/01/2003 - "While some of these pharmacotherapies have been efficacious in treating adult pathological gambling, additional double-blind, placebo-controlled studies are needed to determine the long-term effectiveness of these treatments. "
|3.||Deep Brain Stimulation
08/01/2007 - "Neither patients responded to the standard therapy for gambling behavior, but dramatically improved after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) and early postoperative withdrawal of dopaminergic therapy. "
05/15/2013 - "Deep brain stimulation of the subthalamic nucleus increases premature responding in a rat gambling task."
01/01/2012 - "The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H(2)[(15)O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. "
09/01/2011 - "In this experiment, we investigated the effects of deep brain stimulation of the subthalamic nucleus on one of the central features of pathological gambling: the tendency to chase losses. "
03/01/2011 - "To assess acute effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on decision-making, patients with PD who were eligible for STN-DBS were evaluated using the Iowa Gambling Task (IGT). "
|4.||Surgical Instruments (Clip)
05/01/2011 - "We report on the performance of the NODS-CLiP, an existing brief, three-item screen for problem and pathological gambling, and an alternative four-item screen that demonstrates improved sensitivity, good positive and negative predictive power, and invariance across key demographic groups . "
06/01/2014 - "However, endorsement of lifetime problem gambling on the NODS-CLiP was significantly higher within the mobile sample (10.7 %) and the MPO sample (14.8 %) than the landline sample (6.6 %). "
06/01/2012 - "The NODS-CLiP was used to identify a representative sample of 730 gamblers (54.3% male, mean age 45.3 years) with possible past year gambling problems in order to explore factors that might affect disordered gamblers' motivators for seeking gambling-related help. "
12/01/2009 - "A two-stage NODS-CLiP procedure appears quite promising as an efficient epidemiological instrument for general population research and clinical triage for gambling disorders."
12/01/2009 - "To describe and evaluate tests of the performance of the NODS-CLiP, an efficient standardized diagnostic interview instrument for adult pathological and problem gambling. "
|5.||Psychophysiology (Physiological Psychology)
05/01/1993 - "This study involved the systematic monitoring of the psychophysiology of fruit machine gambling using heart rate measures in 30 adolescent male gamblers. "
12/01/2010 - "The demonstration that physiological changes associated with rapidly occurring win and loss events during electronic gambling can be reliably captured is fundamental to further progress in the psychophysiology of gambling. "