Gallbladder Diseases (Gall Bladder Disease)

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531 relevant articles (30 outcomes, 63 trials/studies) found for this Disease

Description: Diseases of the GALLBLADDER. They generally involve the impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, neoplasms, or other diseases.

Also Known As:

Gall Bladder Disease; Gallbladder Disease; Gall Bladder Diseases; Bladder Disease, Gall; Bladder Diseases, Gall; Disease, Gall Bladder; Disease, Gallbladder; Diseases, Gall Bladder; Diseases, Gallbladder

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 29

Biliary Tract Diseases: 303

Gallbladder Diseases: 531

Cholecystitis: 1327

Gallbladder Neoplasms: 499

Cholecystolithiasis: 263

Related Diseases

1.	Cholelithiasis
2.	Breast Neoplasms (Breast Cancer)
3.	Stroke (Strokes)
4.	Thromboembolism
5.	Osteoporosis

Experts

1.	Ruhl, C E: 3 articles (11/2001 - 02/2000)
2.	Everhart, J E: 3 articles (11/2001 - 02/2000)
3.	Liu, Bette: 1 article (01/2008)
4.	Reeves, Gillian: 1 article (01/2008)
5.	Sweetland, Siân: 1 article (01/2008)
6.	Balkwill, Angela: 1 article (01/2008)
7.	Green, Jane: 1 article (01/2008)
8.	Million Women Study Collaborators: 1 article (01/2008)
9.	Beral, Valerie: 1 article (01/2008)
10.	Völzke, H: 1 article (07/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gallbladder Diseases:

1.	Cholecystokinin (Pancreozymin)IBA 05/01/1980 - "It is concluded that in some individuals with continuing symptoms suggesting gallbladder disease but normal oral cholecystograms, cholecystokinin cholecystography may be helpful in identifying physiologic dysfunction of the gallbladder." 01/01/1992 - "The physiologic studies on gallbladder contraction and cholecystokinin release in a subset of the patients failed to provide information on a mechanism for the possible increased incidence of gallbladder disease." 09/01/1985 - "The objective of this study was to examine the effect of aging on gallbladder contraction and cholecystokinin (CCK) release, as well as on the correlation between the two in humans who are free of gallbladder disease" 07/01/2003 - "Acalcolous gallbladder disease is the clinical setting deserving further investigation on the value of the cholecystokinin provocative test, but this test needs to be standardized." 06/01/2001 - "Diagnostic accuracy of 99Tcm-HIDA with cholecystokinin and gallbladder ejection fraction in acalculous gallbladder disease." Order ALL the reference details at left...
2.	Estrogens (Estrogen)FDA Link 01/19/2005 - "Both trials showed greater risk of any gallbladder disease or surgery with estrogen (CEE: HR, 1.67; 95% CI, 1.35-2.06; E + P: HR, 1.59; 95% CI, 1.28-1.97)" 01/01/1988 - "Although an increase in the risk of gallbladder disease in women using supplemental estrogens has been consistently observed in previous studies, the risk after cessation of use has received little attention but could be important" 04/01/1982 - "An increased risk of gallbladder disease may be associated with estrogen therapy, but this risk is minimal and has not been observed in all studies" 01/19/2005 - "OBJECTIVE: To determine the effect of estrogen therapy in healthy postmenopausal women on gallbladder disease outcomes" 01/19/2005 - "Effect of estrogen therapy on gallbladder disease." Order ALL the reference details at left...
3.	CholesterolIBA 09/01/1997 - "Because it had been shown that an elevated total serum cholesterol was associated with phenotype A in many western European and Japanese populations as compared to non-A phenotype, a study was conducted to see whether there was any correlation between ABO blood group and gall bladder disease in our environment" 08/15/1987 - "These results, which need to be confirmed by further studies, show that in acalculous gallbladder disease there is a delay in gallbladder emptying which could explain the formation of cholesterol crystals by bile stasis as described by various authors." 10/01/2008 - "Results: The quantity of cholesterol was significantly less in the GS of GBC than in benign gallbladder diseases (CC or XGC, P < 0.0001 for both)" 04/01/2003 - "Cholesterol crystal morphology in acalculous gallbladder disease." 06/01/1994 - "The results support the view that gallbladder disease presents histological evidence of biliary complications more often in patients with multiple cholesterol stones than in those with solitary stones." Order ALL the reference details at left...
4.	Sincalide FDA Link 11/01/2004 - "DATA SYNTHESIS: Five human studies investigated the safety and efficacy of sincalide in patients with PN-associated gallbladder disease" 04/01/2006 - "For chronic acalculous gallbladder disease, calculation of a gallbladder ejection fraction during sincalide cholescintigraphy can confirm the clinical diagnosis and has become a common routine procedure in many nuclear medicine clinics" 06/01/1996 - "Findings of hepatobiliary scintigraphy with intravenous cholecystokinin octapeptide (sincalide) were examined in 26 asymptomatic patients with various malignancies but no known pre-existing gallbladder disease, and normal hepatobiliary and gallbladder morphology on sonography" 09/01/1986 - "These findings suggest that the ability of CCK-8 to maintain high bile flows during TPN may have prophylactic relevance for prevention of TPN-induced gallbladder disease" 06/01/1985 - "The role of sincalide cholescintigraphy in the evaluation of patients with acalculus gallbladder disease." Order ALL the reference details at left...
5.	PlacebosIBA 01/01/1979 - "Conclusions reached by the conference participants were: 1) estrogens are more effective than placebos in reducing vasomotor symptoms associated with menopause; 2) therapy should be undertaken only if the patient considers the symptoms to be severe enough to warrant treatment, and the smallest dose possible should be administered; 3) estrogens are effective in treating atrophy of the vaginal epithelium, but the use of estrogen creams to treat localized vaginal areas needs further study; 4) estrogens should not be used to treat primary psychological problems; 5) insufficient data is available for determining whether estrogen therapy decreases the risk of fracture associated with osteoporosis; 6) recent investigations indicate estrogen therapy reduces bone loss, but it is not known if the effect is permanant; 7) estrogen therapy appears to neither increase nor decrease the risk of thromboembolism, stroke, or heart disease; 8) estrogen therapy is associated with an increased risk of endometrial cancer but primarily with low grade endometrial cancers; 9) cystic hyperplasia is associated with unopposed estrogen therapy; 10) yearly endometrial samples should be obtained and checked for endometrial changes for all patients receiving estrogen therapy; 11) evidence supporting an association between estrogen therapy and breast cancer is indecisive; and 12) estrogen therapy is associated with an increased risk of gallbladder disease" Order ALL the reference details at left...
6.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 02/01/1999 - "The prostanoid response of gallbladder cells stimulated by proinflammatory agents is inhibited by COX-2 inhibitors suggesting that these agents may be effective in treating the pain and inflammation of gallbladder disease." Order ALL the reference details at left...
7.	Cyclooxygenase InhibitorsIBA 09/01/1989 - "Cyclooxygenase inhibitors decrease gallbladder prostaglandin formation and are effective in producing relief of the symptoms of gallbladder disease" Order ALL the reference details at left...
8.	HormonesIBA 07/01/2007 - "OBJECTIVE: Several studies suggest that oral menopausal hormone therapy (MHT) is associated with an increased risk of gallbladder disease" 07/01/2007 - "Menopausal hormone therapy and gallbladder disease: the Study of Health in Pomerania (SHIP)." 06/01/1980 - "Part II. Clinical study: fluorescence histochemical studies in various gallbladder disease in human--especially on relationship between autonomic nerves, digestive tract hormones, EC-cells and mast cells (author's transl)]" 08/19/1998 - "Within the overall null effect, there was a statistically significant time trend, with more CHD events in the hormone group than in the placebo group in year 1 and fewer in years 4 and 5. More women in the hormone group than in the placebo group experienced venous thromboembolic events (34 vs 12; RH, 2.89; 95% CI, 1.50-5.58) and gallbladder disease (84 vs 62; RH, 1.38; 95% CI, 1.00-1.92)" 05/15/1950 - "Adrenocortical hormone therapy of chronic gallbladder disease.]" Order ALL the reference details at left...
9.	Oral ContraceptivesIBA 01/22/1976 - "The reported association between use of oral contraceptives (0C) and gallbladder disease led to a study of the effects of OCs on lipid compos ition of gallbladder bile on 22 healthy women between the ages of 19 and 39" 01/01/2006 - "Oral contraceptives do not pose a greater risk for gallbladder disease" 08/01/1994 - "It is concluded that it is unlikely that oral contraceptives are of either clinical or public health significance in relation to the occurrence of gallbladder disease." 01/01/1994 - "Current users of oral contraceptives had a moderately increased risk of symptomatic gall bladder disease (relative risk 1.15; 95% CI 0.99 to 1.34), unlike former users (relative risk 1.03; 95% CI 0.90 to 1.18)" 08/01/1993 - "Considering the large efforts already devoted to this exposure-disease relationship, the probably weak effect, and the rapidly changing formulas of oral contraceptives, the authors suggest that the safety of new oral contraceptives be evaluated by studying bile saturation and biliary function rather than by waiting for gallbladder disease to develop." Order ALL the reference details at left...
10.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 08/01/1998 - "OBJECTIVES: This study examined the correlates of clinical gallbladder disease among US adults and whether serum ascorbic acid levels are associated with a decreased prevalence of gallbladder disease" 04/10/2000 - "Serum ascorbic acid level was inversely related to prevalence of clinical and asymptomatic gallbladder disease among women, but not among men" 04/10/2000 - "Serum ascorbic acid and gallbladder disease prevalence among US adults: the Third National Health and Nutrition Examination Survey (NHANES III)." 08/01/1998 - "An inverted U-shaped relation was found between serum ascorbic acid level and clinical gallbladder disease among women but not among men" 08/01/1998 - "Serum ascorbic acid and other correlates of gallbladder disease among US adults." Order ALL the reference details at left...

Therapies and Procedures

1.	Laparoscopic Cholecystectomy 09/01/2006 - "BACKGROUND: Laparoscopic cholecystectomy is the gold standard treatment for most gallbladder diseases" 02/01/2003 - "PURPOSE: Laparoscopic cholecystectomy (LC) is accepted as a "gold standard" for treating most gallbladder diseases because it is superior to the open method, causes less postoperative pulmonary dysfunction, and promotes earlier postoperative recovery" 11/01/1994 - "Laparoscopic cholecystectomy is a major advance in the management of patients with symptomatic gall-bladder disease" 05/01/1993 - "Laparoscopic cholecystectomy is a major advance in the management of patients with symptomatic gallbladder disease" 03/01/2002 - "CONCLUSION: We conclude that elective laparoscopic cholecystectomy in elderly with uncomplicated gallbladder disease is safe and effective and we suggest that it may become the surgical procedure of choice." Order ALL the reference details at left...
2.	Cholecystectomy 01/01/1991 - "Laparoscopic guided cholecystectomy appears to offer a number of advantages in patient care as well as a significant reduction in health care expenses for gallbladder disease" 10/01/1988 - "This compares well with patients undergoing cholecystectomy for uncomplicated calculous gallbladder disease, 88 per cent of whom, in our study, were improved by surgery" 05/01/1986 - "The presence of bilirubinate sludge may predict symptomatic improvement in those patients with acalculous gallbladder disease undergoing cholecystectomy." 12/01/1984 - "Intraoperative ultrasonography shows promise in detecting nonpalpable gallbladder disease and decreasing the incidence of delayed cholecystectomy." 04/01/2008 - "RESULTS: Some 25,743 patients were admitted as an emergency with acute gallbladder disease, of whom 3791 had an emergency cholecystectomy during the first admission (open cholecystectomy (OC) 29.8 per cent, laparoscopic conversion rate (LCR) 10.7 per cent) and 9806 patients had an elective cholecystectomy (OC 11.3 per cent, LCR 8.3 per cent) during the study period" Order ALL the reference details at left...
3.	Estrogen Replacement Therapy 05/01/2000 - "OBJECTIVE: To examine the role of estrogen replacement therapy on the development of gallbladder disease in postmenopausal women" 05/01/2000 - "Estrogen replacement therapy and gallbladder disease in postmenopausal women." 09/01/1981 - "Studies have shown that side effects of estrogen replacement therapy include endometrial cancer, hypertension, gallbladder disease, and angina pectoris" 02/01/1983 - "Complications of estrogen replacement include endometrial cancer, breast cancer, hypertension, hyperlipidemia, and gallbladder disease, the latter 3 apparently resulting from hepatic action of estrogen replacement therapy" 12/01/2003 - "Postmenopausal hormone replacement therapy is helpful in relieving menopausal vasomotor symptoms and vaginal atrophy and can prevent osteoporosis; however, attendant risks include breast cancer, thromboembolism, gallbladder disease, stroke, CHD, dementia, and hypertriglyceridemia" Order ALL the reference details at left...
4.	Microbubbles 04/01/1998 - "We evaluated the efficacy of contrast-enhanced ultrasonography (CEUS) with intra-arterial injection of CO2 microbubbles in 37 cases of gall bladder diseases" 09/01/2002 - "Thirteen patients with gallbladder disease underwent power Doppler ultrasound (PDUS) before and after microbubble contrast agent injection" 11/01/1994 - "Ultrasonographic (US) angiography was performed by sonographic examination with injection of carbon dioxide microbubbles through a catheter following conventional angiography in 41 patients with various gallbladder diseases" Order ALL the reference details at left...
5.	Hormone Replacement Therapy (Therapy, Hormone Replacement) 05/01/2000 - "All studies that addressed the association between hormone replacement therapy and gallbladder disease published from 1970 to the present were reviewed" 01/01/1999 - "Among the associations considered here, only an increased risk of gallbladder disease and venous thromboembolic disease have been confirmed in clinical trials of hormone replacement therapy" 01/01/2008 - "CONCLUSION: Gallbladder disease is common in postmenopausal women and use of hormone replacement therapy increases the risk" 01/01/2008 - "Compared with never users of hormone replacement therapy, current users were more likely to be admitted for gallbladder disease (relative risk 1.64, 95% confidence interval 1.58 to 1.69) but risks were substantially lower with transdermal therapy than with oral therapy (relative risk 1.17, 1.10 to 1.24 v 1.74, 1.68 to 1.80; heterogeneity P<0.001)" 01/01/2008 - "OBJECTIVE: To determine whether transdermal compared with oral use of hormone replacement therapy reduces the risk of gallbladder disease in postmenopausal women" Order ALL the reference details at left...

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