UTP-Hexose-1-Phosphate Uridylyltransferase (UTP Hexose 1 Phosphate Uridylyltransferase)

An enzyme that catalyzes the synthesis of UDPgalactose from UTP and galactose-1-phosphate. It is present in low levels in fetal and infant liver, but increases with age, thereby enabling galactosemic infants who survive to develop the capacity to metabolize galactose. EC 2.7.7.10.

Also Known As:

UTP Hexose 1 Phosphate Uridylyltransferase; Galactose-1-Phosphate Uridyltransferase; Galactose 1 Phosphate Uridyltransferase; Galactose Pyrophosphorylase, UDP; Pyrophosphorylase, UDP Galactose; Uridyltransferase, Galactose-1-Phosphate; Uridylyltransferase, Galactosephosphate; Uridylyltransferase, UTP-Hexose-1-Phosphate; Galactosephosphate Uridylyltransferase; UDP Galactose Pyrophosphorylase; UTP:alpha-D-hexose-1-phosphate uridylyltransferase

Networked: 141 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Nucleotidyltransferases: 29
        UTP-Hexose-1-Phosphate Uridylyltransferase: 141
        human GALT protein

Experts

1.	Lai, Kent: 6 articles (01/2019 - 11/2005)
2.	Berry, Gerard T: 6 articles (05/2012 - 06/2004)
3.	Elsas, L J: 6 articles (04/2001 - 03/2000)
4.	Bosch, Annet M: 5 articles (09/2021 - 05/2004)
5.	Tang, Manshu: 5 articles (01/2019 - 11/2005)
6.	Lai, K: 4 articles (09/2011 - 05/2000)
7.	Treacy, Eileen P: 3 articles (09/2021 - 05/2009)
8.	Hanisch, Franz-Georg: 3 articles (01/2020 - 01/2016)
9.	Mao, Rong: 3 articles (11/2018 - 10/2007)
10.	Pasquali, Marzia: 3 articles (11/2018 - 01/2018)

Related Diseases

1.	Galactosemias (Galactosemia) 03/01/2010 - "Availability of the galactose-1-phosphate uridyltransferase (GALT) assay for newborn (NB) screening has improved identification of classic galactosemia. " 01/01/2018 - "All four studies describing screening strategies used TGAL as the primary screening marker combined with galactose-1-phosphate uridyltransferase (GALT) measurement that is used for classical galactosemia screening. " 02/01/2000 - "A study of the galactose-1-phosphate uridyltransferase (GALT) gene from 37 unrelated galactosemia families is reported here. " 08/01/1994 - "This study was conducted to determine whether there is a genotype/phenotype correlation between aspects of cognitive, neurologic, and ovarian outcome in patients with galactosemia and the Q188R mutation of the galactose-1-phosphate uridyltransferase gene. " 12/01/2022 - "It is caused by a complete or severe deficiency of galactose-1-phosphate uridyltransferase (GALT), and in rare cases, atypical galactosemia can manifest at older ages. "
2.	Cataract (Cataracts) 09/01/1991 - "[Study of galactose-1-phosphate uridyltransferase activity in erythrocytes of patients with presenile cataract]." 01/01/2003 - "Mutations in galactose-1-phosphate uridyltransferase gene in patients with idiopathic presenile cataract." 01/01/1987 - "We have evaluated the levels of red blood cell galactose-1-phosphate uridyltransferase in 20 patients with cataract and in 15 subjects without cataract, suffering from compensated, noninsulin-dependent, type II diabetes. " 01/01/2003 - "Impaired activity of the enzyme galactose-1-phosphate uridyltransferase (GALT) has been proposed as a risk factor for idiopathic presenile cataract. " 05/01/1996 - "Classical galactosaemia caused by deficiency of galactose-1-phosphate uridyltransferase (GALT) is characterized by acute symptoms of hepatocellular dysfunction, sepsis, cataracts and failure to thrive. "
3.	Primary Ovarian Insufficiency 10/01/2005 - "The present study was aimed at mutational screening of the gene coding for galactose-1-phosphate uridyltransferase in females with premature ovarian failure within an Indian population. " 12/01/2007 - "Female patients with classical galactosemia (galactose-1-phosphate uridyltransferase [GALT] deficiency) frequently suffer from premature ovarian failure, despite treatment with a galactose-restricted diet. " 12/01/2000 - "The risk for premature ovarian failure (POF) in females with galactosemia can be predicted by analyzing 3 areas of risk pathology: the patient's molecular genotype for galactose-1-phosphate uridyltransferase (GALT), alternate pathways for galactose metabolism, and the patient's environment at diagnosis and during treatment. "
4.	Ovarian Neoplasms (Ovarian Cancer) 10/15/2002 - "Association of galactose-1-phosphate uridyltransferase activity and N314D genotype with the risk of ovarian cancer." 02/01/2005 - "We collected epidemiological studies related to the association between milk/dairy products consumption or galactose metabolism (lactose, galactose, galactose-1-phosphate uridyltransferase, lactose/transferase) and ovarian cancer published between January 1966 and August 2003 and found 27 items from 22 independent studies. "
5.	Apraxias (Dyspraxia) 03/01/2000 - "This study evaluates a genotype/phenotype relationship between developmental verbal dyspraxia (DVD) and the common, missense mutation of the galactose-1-phosphate uridyltransferase gene, Q188R, in patients with classic galactosemia (G/G). "

Related Drugs and Biologics

1.	A 7 (A-7)
2.	Galactose (Galactopyranose)
3.	Enzymes
4.	Isotopes
5.	Lactose
6.	Transferases
7.	Folic Acid (Vitamin M)
8.	galactose-1-phosphate
9.	Uridine Diphosphate (UDP)
10.	Galactokinase

Related Therapies and Procedures

1.	Blood Transfusion (Blood Transfusions)