Fumarates

02/01/2017 - "Fumaric acid esters (FAEs) have proven efficacy in the treatment of psoriasis and have been in use for decades. "
02/01/2010 - "Fumaric acid esters (FAE) are used in Germany as a first-line systemic treatment for chronic plaque psoriasis, with proven efficacy and low toxicity. "
05/01/2016 - "Fumaric acid esters (FAE) are beneficial in the treatment of psoriasis. "
12/01/2011 - "Our successful therapy consisted of fumaric acid esters according to the therapeutic schedule for psoriasis and showed a good tolerance subjectively and objectively."
04/26/2006 - "The major conclusions from the results of medical RCT on moderate and severe psoriasis vulgaris are: Oral fumarates are effective in the treatment of moderate to severe psoriasis vulgaris. "

01/01/2022 - "Gastrointestinal intolerance (20%-42%), infection (6%-18%), and decreased lymphocyte count (4%-9%) were more common with tepilamide fumarate. "
01/01/2020 - "Together, these findings contribute to defining a mitochondrial signature associated with the induction of innate immune training by fumarate treatment, and to the understanding of whole organism infection resistance."
11/09/2023 - "Here, we found that enterohemorrhagic Escherichia coli (EHEC) O157:H7 imports host- and microbiota-derived L-malate using the DcuABC transporters and converts these substrates into fumarate to fuel anaerobic fumarate respiration during infection, thereby promoting its colonization of the host intestine. "
01/01/2023 - "These findings suggest fumarate can be employed as an antibiotic adjuvant to effectively treat infections induced by bacterial biofilms/microcolonies in a 3D-confined environment."
12/21/2021 - "Restraint of Fumarate Accrual by HIF-1α Preserves miR-27a-Mediated Limitation of Interleukin 10 during Infection of Macrophages by Histoplasma capsulatum."

06/01/2005 - "Recently, in several case reports, fumaric acid esters (FAE) have proved beneficial in granulomatous skin diseases, but studies on a larger collection of consecutive patients have not yet been performed. "
06/01/2005 - "Therapy of noninfectious granulomatous skin diseases with fumaric acid esters."
07/01/2006 - "Fumaric acid esters (FAE) have proven their therapeutic efficacy in psoriasis, a Th1 mediated skin disease. "
11/01/2012 - "According to this data, fumarates may represent a new approach in the treatment of granulomatous and inflammatory skin diseases other than psoriasis vulgaris. "
11/01/2012 - "To examine the efficacy and safety of fumarates for the treatment of granulomatous and inflammatory skin diseases other than psoriasis vulgaris. "

03/01/2001 - "[Granuloma annulare disseminatum: successful therapy with fumaric acid ester]."
01/01/2005 - "Treatment of granuloma annulare with fumaric acid esters (FAE) has recently been reported to be effective in 2 patients. "
05/01/2013 - "Successful treatment of disseminated granuloma annulare with oral fumaric acid esters."
01/01/2009 - "Low-dose fumaric acid esters significantly improve disseminated granuloma annulare in approximately 63% of patients. "
01/01/2009 - "Disseminated granuloma annulare has also been reported to respond to fumaric acid esters. "

01/01/2014 - "The present case and similar reports in the literature highlight the probable efficacy of fumaric acid esters in the treatment of sarcoidosis and other non-infectious, granulomatous diseases."
10/01/2021 - "[Low-dose, long-term fumaric acid esters in recalcitrant cutaneous sarcoidosis : Report of two cases]."
01/01/2014 - "Multi-organ sarcoidosis treatment with fumaric acid esters: a case report and review of the literature."
06/01/2004 - "This case demonstrates a possible role for fumaric acid esters not only in the treatment of cutaneous but also systemic sarcoidosis."
06/01/2004 - "[Successful treatment of skin and lung sarcoidosis with fumaric acid ester]."