|1.||Linehan, W Marston: 19 articles (12/2014 - 12/2003)|
|2.||Aaltonen, Lauri A: 14 articles (11/2013 - 04/2002)|
|3.||Launonen, Virpi: 12 articles (11/2010 - 04/2002)|
|4.||Pollard, Patrick J: 11 articles (05/2014 - 01/2006)|
|5.||Kiuru, Maija: 10 articles (06/2010 - 04/2002)|
|6.||Lehtonen, Rainer: 8 articles (06/2010 - 04/2002)|
|7.||Yang, Youfeng: 7 articles (12/2014 - 08/2009)|
|8.||Aittomäki, Kristiina: 7 articles (06/2010 - 04/2002)|
|9.||Frizzell, Norma: 6 articles (11/2015 - 10/2011)|
|10.||Neckers, Len: 6 articles (12/2014 - 08/2005)|
05/21/2002 - "Ibuprofen and its major metabolites were incubated with catalase and fumarase, in the presence of protein-modifying biomolecules, to explore the mode of action of ibuprofen in protection against cataract. "
05/21/2002 - "Protective effects of ibuprofen and its major metabolites against in vitro inactivation of catalase and fumarase: relevance to cataract."
09/01/2011 - "Validation included the use of mice with targeted inactivation of fumarate hydratase in the kidney, extensive studies of normal human tissues and examination of over 1000 specimens from human cancers not associated with FH mutations. "
10/01/2015 - "Indeed, a limited subset of PBMAH can be observed as part of multiple tumors syndromes due to alterations of the APC, Menin or Fumarate Hydratase genes. "
05/01/2015 - "Alterations in nuclear factor (erythroid-derived 2)-like 2, Kelch-like erythroid-derived cap-n-collar homology-associated protein 1, and cullin 3, components of an oxidative stress response pathway, have been recently recognized in some sporadic papillary tumors as well as in fumarate hydratase-deficient tumor and may serve as additional therapeutic targets. "
03/01/2015 - "This syndrome is an autosomal dominant disorder caused by a heterozygous germline mutation of the gene that encodes fumarate hydratase, a Krebs cycle enzyme that acts as a tumor suppressor. "
12/08/2014 - "Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer."
|3.||Kidney Neoplasms (Kidney Cancer)
01/01/2015 - "Mutations in the tricarboxylic acid (TCA) cycle enzyme fumarate hydratase (FH) are associated with a highly malignant form of renal cancer. "
12/08/2014 - "Patients with germline fumarate hydratase (FH) mutation are predisposed to develop aggressive kidney cancer with few treatment options and poor therapeutic outcomes. "
12/08/2014 - "DisABLing kidney cancers caused by fumarate hydratase mutations."
01/01/2011 - "Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion."
06/01/2010 - "We report a patient in whom renal cancer was detected at the age of 11 years at his first routine screening imaging after he was found to carry a fumarate hydratase gene mutation (c.1189G > A) transmitted from his mother. "
|4.||Renal Cell Carcinoma (Grawitz Tumor)
12/01/2015 - "Fumarate Hydratase-deficient Cell Line NCCFH1 as a New In Vitro Model of Hereditary Papillary Renal Cell Carcinoma Type 2."
07/01/2015 - "Because of a family history of renal cell cancer, she was tested for fumarate hydratase mutations and found to be a carrier. "
01/01/2013 - "Downregulation of fumarate hydratase is related to tumorigenesis in sporadic renal cell cancer."
12/01/2011 - "Subsets of these patients are at risk for renal cell cancer and have been determined to have mutations in the fumarate hydratase gene. "
10/18/2011 - "Fumarate hydratase (FH) mutation causes hereditary type 2 papillary renal cell carcinoma (PRCC2). "
|5.||Leiomyoma (Uterine Fibroids)
11/01/2004 - "Involvement of fumarate hydratase in nonsyndromic uterine leiomyomas: genetic linkage analysis and FISH studies."
11/01/2015 - "Morphology and Immunohistochemistry for 2SC and FH Aid in Detection of Fumarate Hydratase Gene Aberrations in Uterine Leiomyomas From Young Patients."
07/01/2014 - "We hypothesized that S-(2-succino)-cysteine-positive leiomyomas, indicating fumarate hydratase aberration, have morphologic features that differ from those without S-(2-succino)-cysteine positivity. "
07/01/2014 - "Rare, sporadic uterine leiomyomas arise in the setting of severe metabolic aberration due to a somatic fumarate hydratase mutation. "
01/01/2013 - "We suggest performing fumarate hydratase activity or FH mutation screening in women with onset of uterine fibroids in their 20s and family history of uterine fibroids or other HLRCC-associated malignancies."
|3.||Succinate Dehydrogenase (Fumarate Reductase)
|4.||hereditary Leiomyomatosis and renal cell cancer
|5.||Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))
|7.||Aconitate Hydratase (Aconitase)
|9.||L-Lactate Dehydrogenase (Lactate Dehydrogenase)
|10.||Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)