Fucosyltransferases

Enzymes catalyzing the transfer of fucose from a nucleoside diphosphate fucose to an acceptor molecule which is frequently another carbohydrate, a glycoprotein, or a glycolipid molecule. Elevated activity of some fucosyltransferases in human serum may serve as an indicator of malignancy. The class includes EC 2.4.1.65; EC 2.4.1.68; EC 2.4.1.69; EC 2.4.1.89.

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Networked: 329 relevant articles (2 outcomes, 34 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yan, Qiu: 14 articles (01/2022 - 01/2007)
2.	Liu, Jiwei: 7 articles (01/2021 - 02/2008)
3.	Jia, Li: 5 articles (01/2017 - 09/2014)
4.	Lowe, John B: 5 articles (01/2009 - 10/2004)
5.	Miyoshi, Eiji: 4 articles (12/2021 - 07/2014)
6.	Li, Ming: 4 articles (11/2021 - 01/2018)
7.	Li, Wenzhe: 4 articles (11/2021 - 01/2018)
8.	Taniguchi, Naoyuki: 4 articles (01/2021 - 01/2015)
9.	Shan, Xiu: 4 articles (01/2020 - 04/2015)
10.	Zhou, Huimin: 4 articles (09/2016 - 09/2014)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 10/01/2014 - "Overexpression of α (1,6) fucosyltransferase associated with aggressive prostate cancer." 11/17/2009 - "Alpha 1,3 fucosyltransferases are master regulators of prostate cancer cell trafficking." 01/01/2018 - "Overexpression of α (1,6) fucosyltransferase in the development of castration-resistant prostate cancer cells." 12/10/2013 - "Human fucosyltransferase 6 enables prostate cancer metastasis to bone." 07/01/2014 - "A high expression of alpha-(1-6) fucosyltransferase (FUT8) and haptoglobin was observed in prostate cancer cell line, suggesting that certain kinds of prostate cancer cells produce Fuc-Hpt. "
2.	Adenoma (Adenomas) 03/01/2000 - "Also, expression of fucosyltransferase FT-IV was increased in colorectal adenomas (p = 0.039) and carcinomas (p<0. " 01/15/2013 - "Moreover, eliminating E-selectin ligand-synthesizing α1,3 fucosyltransferases in transgenic adenoma of mouse prostate mice dramatically reduced prostate cancer incidence. "
3.	Esophageal Squamous Cell Carcinoma 01/01/2020 - "Understanding the expression pattern of fucosyltransferase (FUT) genes may help to suggest better-targeted therapy strategies for esophageal squamous cell carcinoma (ESCC). "
4.	Neoplasms (Cancer) 01/01/2007 - "These studies suggest that fucosyltransferase IV may serve as a potential therapeutic target for the treatment of Lewis Y-positive epithelial cancers." 07/01/2023 - "Members of the focused fucosyltransferase (FUT) family participate in the advancement of various types of cancer. " 03/01/2023 - "Corrigendum to "Therapeutic potential of fucosyltransferases in cancer and recent development of targeted inhibitors" [Drug Discov. " 01/01/2023 - "Fucosyltransferase 8 (FUT8) is a potential therapeutic target with high level in most malignant cancers including CRC. " 01/01/2023 - "Fucosyltransferases (FUTs) are associated with numerous cancers. "
5.	Carcinoma (Carcinomatosis) 12/01/2008 - "[alpha1,2-fucosyltransferase gene transfection influences on biological behavior of ovarian carcinoma-derived RMG-I cells]." 09/01/2006 - "Different expression levels of alpha3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines." 04/01/2000 - "These results provide target validation for inhibition of carcinoma proliferation with antisense sequences directed at human fucosyltransferases." 04/01/2000 - "Transfection of alpha(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells." 03/01/1997 - "Increase of rat colon carcinoma cells tumorigenicity by alpha(1-2) fucosyltransferase gene transfection."

Related Drugs and Biologics

1.	Ligands
2.	E-Selectin
3.	Sialyl Lewis X Antigen
4.	Carbohydrates
5.	Sialyltransferases
6.	Antigens
7.	Fucose
8.	Enzymes
9.	Polysaccharides (Glycans)
10.	Selectins

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Diagnosis (Oral Examination)
3.	Drug Therapy (Chemotherapy)
4.	Precision Medicine
5.	Transplantation