Open Fractures (Compound Fracture)

01/01/2020 - "The described multifaceted performance improvement protocol was highly effective for producing a more coordinated, efficient, and timely process for administration of antibiotics to patients with open fractures at our hospital. "
02/01/2020 - "The optimal antibiotic for open fracture prophylaxis remains unclear, and the literature comparing the safety and efficacy of different antibiotic regimens is limited. "
04/01/2011 - "The purpose of this study was to evaluate the efficacy of two different antibiotic regimens in management of type III-A open fractures. "
03/01/2000 - "This study compared the efficacy of antibiotic impregnated beads with conventional intravenous antibiotics in the treatment of open fractures. "
06/01/2015 - "We questioned whether early flap coverage improved the clinical outcome and whether we could improve our antibiotic treatment of open fractures. "

12/01/2016 - "There were 167 patients with open fractures during the study period (119 males, mean age 42 ± 17 [standard deviation] years), with 80 (48%) receiving prophylactic gentamicin (AG+ group). "
06/15/2023 - "Eight hundred ninety patients will be randomized to receive an injection of either gentamicin (treatment group) or saline (control group) at the site of their primarily closed open fracture. "
11/01/2018 - "ICU admission and concurent CT contrasted imaging are strongly associated with kidney injury in patients receiving gentamicin for open fracture treatment, and gentamicin should be avoided in those >60 years of age. "
11/01/2018 - "To evaluate all patients who received gentamicin for open fracture treatment and determine the incidence of, and risk factors for, kidney injury in this population. "
03/01/2016 - "Gentamicin use during the treatment of open fractures does not lead to increased rates of renal dysfunction when used in patients with normal baseline renal function."

08/22/2023 - "We performed this study to evaluate the concentration and pharmacokinetics of intravenously delivered cefazolin at an open fracture site after surgical debridement. "
05/01/2019 - "If open fracture was suspected, the patient was indicated for antibiotic prophylaxis with 2 g IV Cefazolin. "
09/01/2022 - "Two hundred eighty-two patients received prehospital cefazolin for deep wounds or open fractures before their arrival at a single level 2 trauma center during the study period. "
08/22/2023 - "Although cefazolin delivery to open-fracture wound beds was delayed compared with healthy tissues, the cefazolin concentration was sustained above the European Union Committee Antimicrobial Susceptibility Testing modal MIC for S. "
09/01/2022 - "Prehospital providers reliably identified open fractures, and prehospital cefazolin administration was not associated with anaphylactic reactions. "

04/01/2022 - "Although the use of aminoglycosides is widely accepted for treatment of Gustilo type III open fractures, aminoglycosides are often avoided in patients with risk factors. "
11/25/2019 - "There are conflicting recommendations between organizations regarding aminoglycoside use for the prophylaxis of type III open fractures. "
08/01/2014 - "Despite concerns with nephrotoxicity, 24.0%-76.3% of respondents reported the use of aminoglycosides in management of open fractures. "
03/01/2016 - "The purpose of this study was to determine if aminoglycoside administration during the treatment of open fractures leads to acute kidney injury. "
12/01/2016 - "The use of nephrotoxic agents, including aminoglycosides, should be restricted in open fracture patients presenting with hypotension or a high ISS."

05/01/2017 - "The purpose of this study was to compare the outcome of combined circular external fixation and cemented polymethylmethacrylate (PMMA) spacer application between a cohort of patients with grade 3 open fractures and infected tibial nonunions and concomitant segmental bone loss. "
09/01/2015 - "aureus and evaluating incorporation of these drugs into PMMA for treatment of contaminated open fractures. "
08/01/2007 - "Its presence indicates one of two things: Either infection was present at the time the PMMA cement was inserted, or there was a high potential for the development of local sepsis, such as in cases of an open fracture. "
09/01/2015 - "Local antimicrobial delivery through polymethylmethacrylate beads (PMMA), commonly vancomycin, is used for the treatment of contaminated open fractures but has limited activity against Staphylococcus aureus biofilms, which occur commonly in such fractures. "
01/01/1992 - "96 open fractures were managed with the supplemental local use of tobramycin-PMMA-beads. "

01/01/2022 - "One trial compared the use of cooled boiled water with normal saline for cleansing open fractures and found that the effect on the number of fractures infected is uncertain (RR 0.83, 95% CI 0.37 to 1.87); very low-certainty evidence. "
01/01/2022 - "Two trials comparing the use of distilled water with normal saline for cleansing open fractures found that the effect on the number of fractures that were infected is uncertain (RR 0.70, 95% CI 0.45 to 1.09); very low-certainty evidence. "
01/01/2022 - "The effect of tap water compared with normal saline is uncertain; two trials were pooled (RR 0.57, 95% CI 0.30 to 1.07) but the certainty of the evidence is very low. Results from one study comparing the use of distilled water with normal saline for cleansing open fractures found that there may be little or no difference in the number of fractures that healed (RR could not be estimated, all wounds healed); the certainty of the evidence is low. "
01/23/2008 - "The majority of surgeons favour both normal saline and low pressure lavage for the initial management of open fracture wounds. "
05/01/2015 - "It was revealed that all three solutions were comparably effective in bacterial removal while normal saline was superior in minimizing adverse wound inflammation; therefore, the use of normal saline for routine debridement is recommended in the early-stage treatment of open fractures in the trauma clinic and in relief fieldwork."

01/01/2017 - "It was concluded from this study that the use of distilled water compares favourably with isotonic saline as an irrigation solution in open fractures of the lower extremities."
08/01/2023 - "Open Fracture of the Femoral Neck in an Adult: Case Report and Surgical Solution."
11/01/2000 - "This reconstructive method seems to be an original solution for the management of open fractures, and additional proof that well-vascularized skin may be equivalent to a muscle flap, and may be considered for selected patients."
07/01/1997 - "The following case of an grade 3 open fracture of the femur with severe soft-tissue damage, including vascular lesions, with consecutive massive transfusion, should demonstrate that the cardiac-respiratory system can still be stabilized, even if a surgical solution seems impossible."
01/01/1984 - "For the treatment of 25 open fractures - the wooden fixation proved to be the best solution."

11/01/2000 - "However, there appeared to be a high failure rate for the ciprofloxacin Type III open fracture group, with patients being 5.33 times more likely to become infected than those in the combination therapy group. "
09/04/2020 - "To evaluate different concentrations of ciprofloxacin to prevent infection after open fracture contaminated with S. "
09/04/2020 - "Local delivery treatment for contaminated open fracture using chitosan with ciprofloxacin is effective above 25%."
09/01/2016 - "This study aimed to evaluate the effectiveness of prophylaxis of osteomyelitis through experimental model of open fractures with the use of chitosan films, whether or not impregnated with ciprofloxacin. "
09/01/2016 - "Effectiveness of Chitosan Films Impregnated With Ciprofloxacin for the Prophylaxis of Osteomyelitis in Open Fractures: An Experimental Study in Rats."

08/01/2016 - "During the twentieth century, walking cast and ambulation for fresh fractures were developed with plaster and pin incorporated in plaster; the open fracture care concept was introduced with plaster of Paris by Trueta before the external fixation."
01/01/1993 - "The open fracture occurred when the patient was 11 years old and was treated elsewhere with plaster of paris. "
03/01/2010 - "The purpose of this study was to investigate the effect of calcium sulfate impregnated with vancomycin combined with internal fixation in the treatment of open fractures of long bones. "
03/01/2010 - "The use of calcium sulfate impregnated with vancomycin in the treatment of open fractures of long bones: a preliminary study."
05/01/2009 - "Antibiotic-impregnated calcium sulfate use in combat-related open fractures."

08/01/2019 - "Patients' satisfaction following ortho-plastic treatment of lower limb open fractures within and after one week from injury."
07/09/2019 - "Patients with extended soft tissue damage and high-grade compound fractures present a demanding clinical challenge, requiring a complex approach and multiple orthopaedic, plastic, and vascular-reconstructive procedures. "
03/01/2018 - "Introduction We aimed to identify population demographics of motorcyclists and pillion passengers with isolated open lower-limb fractures, to ascertain the impact of the revised 2009 British Orthopaedic Association/British Association of Plastic Reconstructive and Aesthetic Surgeons joint standards for the management of open fractures of the lower limb (BOAST 4), in terms of time to skeletal stabilisation and soft-tissue coverage, and to observe any impact on patient movement. "
04/01/2016 - "Management of open fracture tibia is a complex problem and is a challenge for both orthopaedic and plastic surgeons. "
09/01/2015 - "The standards for the management of open fractures of the lower limb published by the British Association of Plastic, Reconstructive and Aesthetic surgeons (BAPRAS) and British Orthopaedic Association (BOA) were introduced to improve the treatment received by patients after open injury to the lower limb. "

01/01/2020 - "Our study concludes that NPWT therapy does not confer benefit over standard dressing technique for open fractures. "
06/01/2014 - "This is a versatile model and with the concepts presented herein, it can be modified to evaluate various emerging therapies and concepts for open fractures. "
12/01/2011 - "Current therapies fail to meet the challenges of open fractures. "
07/07/2011 - "A retrospective chart review spanning 4.5 years of all pediatric patients younger than 18 years with an open fracture initially treated with VAC therapy was conducted at a level I pediatric trauma center. "
01/01/2010 - "Although anatomic and timely repair of the distal humerus with meticulous handling of soft tissues and appropriate postoperative therapy all help to optimize results, an open fracture presents other challenges that may limit successful outcomes in spite of these measures. "

11/01/2012 - "Although closed reduction and intramedullary nailing remains the treatment of choice for most significantly displaced tibial shaft fractures, open reduction with respectful handling of the soft tissue envelope can be safe and effective and should be considered when less invasive techniques are unsuccessful."
04/01/2016 - "Moreover interlocked intramedullary nailing for open fracture shaft of tibia was safe in 80% patients while this procedure was effective in 85%. "
10/01/1996 - "In previously closed and selected grade I and grade II open fractures, reamed intramedullary nailing is a safe and effective method of treatment. "
01/01/2009 - "The efficacy of flexible intramedullary nailing for open fractures needs further evaluation. "
08/01/2021 - "During the study period, 389 patients underwent tibial intramedullary nailing with 162 identified as open fractures. "

12/01/2013 - "Thus, the 'external fixator' application for the management of open fractures of tibia may give good results even to the poor patients and may be suitable for underdeveloped and developing countries. "
04/01/2006 - "The introduction of external fixation devices has brought significant improvement in the management of complex open fractures. "
08/01/2008 - "The method of pedicle flap transfer combined with external fixator is safe and effective for the leg open fracture with soft tissue defect."
11/01/2020 - "The present study aims to evaluate of the complications which may occur in cases with an application of internal fixation following external fixator in upper and lower extremity open fractures retrospectively. "
11/01/2013 - "[Comparison study on locking compress plate external fixator and standard external fixator for treatment of tibial open fractures]."

08/01/2005 - "Early meticulous debridement, good open reduction and internal fixation with a small DCP proved very effective in the management of type I and II open fractures of both the radial and ulnar diaphyses."
05/01/2015 - "Efficacy of different irrigation solutions on the early debridement of open fracture in rats."
12/01/2013 - "The management of ballistic fractures, which are open fractures, has often been studied in wartime and has benefited from the principles of military surgery with debridement and lavage, and the use of external fixation for bone stabilization. "
01/01/2019 - "A pilot study was done at our institution, where all type 2, 3A, and 3B open fractures admitted in the emergency and operated for debridement and stabilization were included in the study. "
01/01/2017 - "The study included 23 patients applied with debridement + noncontact plate osteosynthesis + soft tissue procedures in a single session for the treatment of an open fracture. "

01/01/2018 - "Negative pressure wound therapy (NPWT) has been revealed to be effective in the treatment of open fractures, although the underlying mechanism is not clear. "
11/01/2015 - "Negative pressure wound therapy (NPWT) is effective in infection control during treatment of severe open fractures. "
05/01/2020 - "To compare the efficacy of negative pressure wound therapy (NPWT) versus conventional dressings (CD) in the management of open fractures. "
09/01/2009 - "Negative pressure wound therapy after severe open fractures: a prospective randomized study."
11/20/2023 - "A simple and rapid technique to achieving an airtight seal for negative pressure wound therapy in externally fixated lower limb open fractures."