A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
Also Known As:
Formyltetrahydrofolate Synthetase; Formate Tetrahydrofolate Ligase; Formylase, Tetrahydrofolate; Ligase, Formate-Tetrahydrofolate; Synthetase, Formyltetrahydrofolate; Tetrahydrofolate Formylase; Formate:tetrahydrofolate ligase (ADP-forming)