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Formate-Tetrahydrofolate Ligase

A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.
Also Known As:
Formyltetrahydrofolate Synthetase; Formate Tetrahydrofolate Ligase; Formylase, Tetrahydrofolate; Ligase, Formate-Tetrahydrofolate; Synthetase, Formyltetrahydrofolate; Tetrahydrofolate Formylase; Formate:tetrahydrofolate ligase (ADP-forming)
Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kirke, Peadar N: 2 articles (04/2009 - 11/2002)
2. Molloy, Anne M: 2 articles (04/2009 - 11/2002)
3. Mills, James L: 2 articles (04/2009 - 11/2002)
4. Brody, Lawrence C: 2 articles (04/2009 - 11/2002)
5. Parle-McDermott, Anne: 2 articles (04/2009 - 11/2002)
6. Scott, John M: 2 articles (04/2009 - 11/2002)
7. Rosenblatt, David S: 1 article (07/2012)
8. Watkins, David: 1 article (07/2012)
9. Pangilinan, Faith: 1 article (04/2009)
10. Carroll, Nicola: 1 article (04/2009)

Related Diseases

1. Neural Tube Defects (Exencephaly)
2. Neoplasms (Cancer)
3. Ascites
4. Megaloblastic Anemia
5. Congenital Abnormalities (Deformity)

Related Drugs and Biologics

1. Methenyltetrahydrofolate Cyclohydrolase
2. Methylenetetrahydrofolate Dehydrogenase (NADP) (Dehydrogenase, Methylenetetrahydrofolate)
3. NADP (NADPH)
4. Folic Acid (Vitamin M)
5. Atypical hemolytic uremic syndrome
6. methylene tetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase