Formiminoglutamic Acid (FIGLU)

Measurement of this acid in the urine after oral administration of histidine provides the basis for the diagnostic test of folic acid deficiency and of megaloblastic anemia of pregnancy.

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Networked: 37 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Feldman, Gerald L: 1 article (11/2017)
2.	Gavrilov, Dimitar: 1 article (11/2017)
3.	Majumdar, Ramanath: 1 article (11/2017)
4.	Matern, Dietrich: 1 article (11/2017)
5.	Oglesbee, Devin: 1 article (11/2017)
6.	Raymond, Kimiyo: 1 article (11/2017)
7.	Rinaldo, Piero: 1 article (11/2017)
8.	Rush, Peggy W: 1 article (11/2017)
9.	Tortorelli, Silvia: 1 article (11/2017)
10.	Yori, Andrew: 1 article (11/2017)

Related Diseases

1.	Folic Acid Deficiency (Folic Acid Deficiencies) 09/28/1961 - "[Formiminoglutamic acid in the urine in folic acid deficiency]." 07/01/1961 - "Conventional voltage electrophoresis for formiminoglutamic-acid determination in folic acid deficiency." 08/13/1960 - "Simplified method for detecting formiminoglutamic acid in urine as a test of folic-acid deficiency." 10/31/1959 - "Excretion of formiminoglutamic acid as an index of folic-acid deficiency." 07/01/1959 - "Urinary excretion of formiminoglutamic acid: application in diagnosis of clinical folic acid deficiency."
2.	Neoplasms (Cancer) 12/22/1967 - "[FIGLU (formimino-glutamic acid): urinary excretion in malignant neoplasms in childhood]." 12/01/1970 - "[Antineoplastic therapy of neoplasms in the female genital sphere: considerations on results of the Figlu test]." 01/01/1967 - "[Urinary excretion of formiminoglutamic acid as a test for folic acid deficiency determination in patients with cancer following surgical treatment, endoxan therapy and cobalt irradiation]."
3.	Malnutrition (Nutritional Deficiencies) 12/01/1962 - "Urinary formiminoglutamic acid in the megaloblastic anaemias associated with pregnancy and malnutrition." 12/01/1968 - "Resistance of liver formiminoglutamic acid transferase to experimental protein malnutrition in weanling rats."
4.	Megaloblastic Anemia 07/01/2003 - "Features of a severe phenotype, first identified in patients of Japanese descent, include elevated levels of formiminoglutamate (FIGLU) in the urine in response to histidine administration, megaloblastic anemia, and mental retardation. " 12/01/1979 - "When these animals were fed the deficient diet, they lost weight rapidly, the alopecia and dermatitis worsened, excretion of formiminoglutamic acid in the urine increased, and a severe megaloblastic anemia with profound intramedullary hemolysis developed. "
5.	Histidinemia 03/12/1982 - "Skin histidase activities and urine formiminoglutamic acid (FIGLU) levels were measured in 20 patients with histidinemia, identified by Guthrie's screening method, and their family members as well as control subjects. " 03/12/1982 - "Skin histidase activity and urine formiminoglutamic acid (FIGLU) in patients with histidinemia found by screening newborn infants." 01/01/1981 - "But in other case of 13 year-old boy without clinical signs of histidinemia, elder brother of former case, serum histidine level was 4.7 mg/dl, histidase activity was 11% of normal control, excretion of FIGLU and urocanic acid in urine, and urocanic acid in sweat were observed, and the half life of histidine was 5 hours and 50 minutes (normal: 2 hours and 20 minutes). " 01/01/1981 - "In a case of 5 year-old boy with clinical histidinemia, in whom serum histidine level was 12.1 mg/kl, histidase activity of stratum corneum was not detectable, FIGLU and urocanic acid in urine and urocanic acid in sweat were not detected, the half life of histidine at intravenous histidine loading test was too long to measure. "

Related Drugs and Biologics

1.	Formiminoglutamic Acid (FIGLU)
2.	Histidine (L-Histidine)
3.	Folic Acid (Vitamin M)
4.	Urocanic Acid
5.	Histidine Ammonia-Lyase
6.	formic acid (formate)
7.	Glutamic Acid (Glutamate)
8.	Vitamin B 12 (Cyanocobalamin)
9.	Transferases
10.	Serum Albumin

Related Therapies and Procedures

1.	Therapeutics
2.	Curettage
3.	Anesthesia