Formazans

Colored azo compounds formed by the reduction of tetrazolium salts. Employing this reaction, oxidoreductase activity can be determined quantitatively in tissue sections by allowing the enzymes to act on their specific substrates in the presence of tetrazolium salts.

Also Known As:

Networked: 125 relevant articles (7 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Xia, Qiang: 9 articles (05/2008 - 01/2005)
2.	Gao, Qin: 7 articles (05/2008 - 01/2005)
3.	Wang, Jue: 4 articles (05/2008 - 01/2007)
4.	Bruce, Iain C: 3 articles (11/2007 - 01/2005)
5.	Pan, Hong-Yang: 3 articles (11/2006 - 01/2005)
6.	Ye, Ting-Mei: 2 articles (01/2007 - 01/2007)
7.	Chen, Bao-Ping: 2 articles (02/2006 - 01/2005)
8.	Fan, Fang-Yan: 2 articles (02/2006 - 01/2005)
9.	Mao, Hong-Jiao: 2 articles (02/2006 - 01/2005)
10.	Fracasso, Giulio: 1 article (05/2022)

Related Diseases

1.	Ischemia 11/01/2006 - "The pretreatment with Pue at 0.24 mmol/L for 5 min before ischemia increased formazan content of myocardium, reduced LDH release, improved the recovery of the left ventricular developed pressure, maximal rise/fall rate of left ventricular pressure, left ventricular end-diastolic pressure and rate pressure product (left ventricular developed pressure multiplied by heart rate) and attenuated the decrease of coronary flow during reperfusion. " 06/13/2006 - "Pretreatment with Pue at 0.24 mmol/l for 5 min before ischemia increased myocardial formazan content, reduced LDH release, improved recovery of left ventricular end-diastolic pressure and rate-pressure product (left ventricular developed pressure multiplied by heart rate) during reperfusion. " 01/15/2000 - "Spectrophotometric measurements of the extract showed a diminished formazan coloration (absorbance/g brain) in all samples from the untreated ischemia group compared to non-operated controls. " 10/01/1994 - "In contrast, the degree of oxidative stress in hepatocytes assessed by formazan deposition after liver perfusion with nitro blue tetrazolium alone was greater after 37 degrees C-ischemia than after 4 degrees C-ischemia. " 05/01/2008 - "In the Langendorff perfused rat heart model, ischemic postconditioning (6 cycles of 10 s reperfusion/10 s global ischemia starting at the beginning of reperfusion) increased formazan content, reduced LDH release, improved the recovery of the left ventricular developed pressure, maximal rise/fall rate of left ventricular pressure and rate pressure product (left ventricular developed pressure multiplied by heart rate), attenuated the decrease of coronary flow during reperfusion and increased the isolated cell viability. "
2.	Plasmacytoma 04/01/1975 - "Lower proportions of formazan granulocytes capable of spontaneous reduction of NBT were found in patients with chronic myeloid leukaemia, in immunohaemolytic anaemias and in plasmocytoma. "
3.	Neoplasms (Cancer) 02/01/2020 - "The antibacterial and cytotoxic activities were investigated on Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria, and in ovarian (A2780) and prostate (PC3) cancer cells by tetrazolium/formazan-based methods. " 02/15/2009 - "In this model, MTT was reduced by viable cancer cells to produce a purple formazan. " 01/01/1953 - "[Formazan reaction in skin tumors]." 01/01/2021 - "The cell viability of the cancer cells was assessed using the tetrazolium compound (MTS reagent), which was reduced to colored formazan, to indicate metabolically active cancer cells in a proliferating assay. " 12/01/2013 - "We compared the sensitivity of six colon-derived cancer cell lines to HY-PDT at IC50 equitoxic doses acquired by formazan-based (MTT) assay. "
4.	Myocardial Infarction 07/01/2010 - "The first group (38 cases) consisted of people where the acute myocardial infarction was the only cause of death (the myocardial lesion could be easily detected by macroscopic examination or by formazan test, other causes of death were excluded and the constriction or obturation of the coronary arteries was detected). " 11/01/1980 - "A possible indication for the use of the K+/Na+ determination together with the formazan test could be cases of instantaneous death by accidents suspected to have been provoked by a fatal heart attack." 05/01/1978 - "If the formazan test is employed as an independent demonstration of myocardial infarction, a total of 16 cases could be demonstrated (as mentioned above), or four times as many as at macroscopic examination at autopsy." 05/01/1978 - "In consecutive medicolegal material comprising 79 persons, the formazan test revealed recent myocardial infarction in 16 cases (20%). " 07/01/1988 - "Although the results showed that the formazan test and K/Na ratio give a good reliability to rule out a myocardial infarction, the most specific technique for the diagnosis of infarct is the formazan test."
5.	Glucosephosphate Dehydrogenase Deficiency 02/01/2003 - "In the present study, 3278 male newborns were screened for G6PD deficiency using the modified formazan method, a simple screening procedure affordable in the setting of a developing country. " 02/01/2003 - "Screening for glucose-6-phosphate dehydrogenase deficiency using a modified formazan method: a pilot study on Filipino male newborns." 01/01/2003 - "In 1996, we detected 145 neonates with G6PD deficiency using the formazan ring method. " 06/01/1999 - "Evaluation of the blue formazan spot test for screening glucose 6 phosphate dehydrogenase deficiency." 05/01/1985 - "Two cell populations of almost equal size could be discerned in heterozygotes for G6PD deficiency, one completely negative, the other with a variable amount of formazan per cell. "

Related Drugs and Biologics

1.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
2.	Bromides
3.	Coloring Agents (Dyes)
4.	Nitroblue Tetrazolium
5.	Oxidoreductases (Dehydrogenase)
6.	diphenyl (biphenyl)
7.	Adenosine Triphosphate (ATP)
8.	Eosine Yellowish-(YS) (Eosin)
9.	Acridine Orange
10.	becatecarin (XL 119)

Related Therapies and Procedures

1.	Ischemic Postconditioning
2.	Tourniquets
3.	Therapeutics
4.	Synchrotrons
5.	Ligation