Formaldehyde (Formol)

A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
Also Known As:
Formol; Formalin; Methanal; Oxomethane
Networked: 12883 relevant articles (268 outcomes, 1531 trials/studies)

Relationship Network

Drug Context: Research Results


1. Granados-Soto, Vinicio: 25 articles (10/2015 - 01/2002)
2. Butkevich, I P: 22 articles (07/2015 - 06/2001)
3. Ross, Jeffrey S: 21 articles (08/2015 - 03/2002)
4. Fountzilas, George: 20 articles (07/2015 - 01/2008)
5. Höfler, Heinz: 20 articles (11/2014 - 09/2002)
6. Yoon, Myung Ha: 19 articles (04/2015 - 09/2003)
7. Cheng, Liang: 18 articles (01/2015 - 01/2002)
8. Becker, Karl-Friedrich: 16 articles (11/2014 - 11/2002)
9. Maione, Sabatino: 16 articles (09/2014 - 06/2002)
10. Tamaddonfard, Esmaeal: 15 articles (10/2015 - 08/2004)

Related Diseases

1. Pain (Aches)
10/15/2012 - "Relative to the NTg controls, GET-1 mice displayed a marked decrease in pain-like behavioral responses during the second phase of formalin-induced pain (i.e., 15-20 min after injection), whereas the responses elicited in TET-1 mice were unaltered. "
01/01/2010 - "The results indicated that II produces higher analgesic effects in the tail immersion test compared to the PCP and control groups, with a marked and significant increase in tail immersion latency for the doses 1, 5 and 10 mg/kg. The formalin test showed that PD (II) is not effective in acute chemical pain (phase I, 0-5 min after injection) in all doses but chronic pain (initial-phase II, 15-40 min after injection) is significantly attenuated by this compound compared to PCP and saline (control) in dosesof 5 and 10 mg/kg. It is concluded that II is effective in acute thermal (in all doses) and chronic (doses of 5 and 10 mg/kg) pains; however, it is not effective in acute chemical pain compared to PCP and control."
05/01/2014 - "In the formalin-induced paw lick test, the extract at 100 and 200 mg/kg doses exhibited good analgesic activity characterized by a significant reduction in the number of paw licks at both the early and the late phases of the induced pain when compared with the untreated control group. "
01/01/2012 - "Hydroalcoholic extracts also significantly reduced pain responses in early and late phases of the formalin test whereas the polyphenolic extract and essential oil were only effective in the late phase of the formalin test. "
02/01/2010 - "The order of testing had no effect on the pain response--there were no differences between the numbers of flexion + shaking patterns in either prenatally stressed rat pups or unstressed animals; measures of the pain response were significantly greater in the sequence in which the formalin test was followed by the Porsolt test in prenatally stressed individuals as compared with unstressed animals. "
2. Infection
3. Neoplasms (Cancer)
4. Proctitis
5. Hyperalgesia

Related Drugs and Biologics

1. Paraffin
2. DNA (Deoxyribonucleic Acid)
3. Acetic Acid (Vinegar)
4. Ethyl Ether (Ether)
5. Antigens
6. Antibodies
7. Carrageenan
8. Vaccines
9. Morphine (MS Contin)
10. Streptozocin (Streptozotocin)

Related Therapies and Procedures

1. Ligation
2. Enema (Enemas)
3. Analgesia
4. Drug Therapy (Chemotherapy)
5. Lasers (Laser)