Foot Rot

A disease of the horny parts and of the adjacent soft structures of the feet of cattle, swine, and sheep. It is usually caused by Corynebacterium pyogenes or Bacteroides nodosus (see DICHELOBACTER NODOSUS). It is also known as interdigital necrobacillosis. (From Black's Veterinary Dictionary, 18th ed)

Also Known As:

Networked: 99 relevant articles (11 outcomes, 8 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Mycoses (Diseases, Fungus)
2.	Bacterial Infections (Bacterial Infection)
3.	Infections
4.	Pneumonia (Pneumonitis)
5.	Pain (Aches)

Experts

1.	Zhou, Jianuan: 2 articles (08/2021 - 12/2020)
2.	Balmas, Virgilio: 2 articles (12/2012 - 10/2011)
3.	Migheli, Quirico: 2 articles (12/2012 - 10/2011)
4.	Scherm, Barbara: 2 articles (12/2012 - 10/2011)
5.	Spanu, Francesca: 2 articles (12/2012 - 10/2011)
6.	Davies, John K: 2 articles (05/2008 - 07/2007)
7.	Han, Xiaoyan: 2 articles (05/2008 - 07/2007)
8.	Kennan, Ruth M: 2 articles (05/2008 - 07/2007)
9.	Rood, Julian I: 2 articles (05/2008 - 07/2007)
10.	Gaab, Tara: 1 article (02/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Foot Rot:

1.	VaccinesIBA 09/01/1983 - "Hence a vaccine containing 38 micrograms of purified pili in IFA is nearly optimal for homologous protection against severe foot rot and is acceptable in terms of the reaction at the injection site." 08/05/1989 - "The vaccine conferred statistically significant protection against foot rot. " 08/05/1989 - "Efficacy of a multivalent Bacteroides nodosus vaccine against foot rot in sheep in Britain." 12/01/1986 - "A field trial with a commercial vaccine against foot-rot in sheep." 11/15/1985 - "An 18-week field trial was conducted on a sheep ranch to evaluate the therapeutic and prophylactic effect of a commercial foot rot vaccine. "
2.	Oxytetracycline (Terramycin)FDA Link 08/01/1981 - "A test was designed to evaluate the efficacy of a new oxytetracycline aerosol in the treatment of foot rot in sheep. " 08/01/1981 - "Efficacy of a new oxytetracycline aerosol against foot rot in sheep." 01/01/2003 - "Two clinical trials evaluated the efficacy of ceftiofur sodium versus placebo for naturally occurring foot rot, and two trials compared the efficacy of ceftiofur sodium or hydrochloride (1.0 mg CE/kg) with oxytetracycline (6.6 or 10 mg/kg), each administered once daily for 3 days, for treatment of acute foot rot in beef cattle. " 01/15/1998 - "Comparison of ceftiofur sodium and oxytetracycline for treatment of acute interdigital phlegmon (foot rot) in feedlot cattle."
3.	ethylenediamine (ethylenediamine dihydroiodide)FDA Link 11/01/1984 - "Efficacy of ethylenediamine dihydriodide in the prevention of naturally occurring foot rot in cattle." 06/01/1984 - "Efficacy of ethylenediamine dihydriodide as an agent to prevent experimentally induced bovine foot rot." 11/01/1984 - "The efficacy of an ethylenediamine dihydriodide containing salt mixture was evaluated with regard to the prevention of naturally occurring foot rot in pastured cattle. " 05/01/1976 - "The addition of ethylenediamine dihydriodide or urea to the rations did not affect the frequency of experimentally induced foot rot." 05/01/1976 - "Experimentally induced foot rot in feedlot cattle fed rations containing organic iodine (ethylenediamine dihydriodide) and urea."
4.	ceftiofurIBA 01/01/2003 - "All trials demonstrated the efficacy of ceftiofur for treatment of acute bovine foot rot. " 01/01/2003 - "A comprehensive review of ceftiofur sodium and hydrochloride formulations for treatment of acute bovine foot rot." 07/01/2002 - "Ceftiofur has worldwide approvals for respiratory disease in swine, ruminants (cattle, sheep and goats) and horses and has also been approved for foot rot and metritis infections in cattle. " 01/15/1998 - "To determine whether ceftiofur sodium would be useful for treatment of acute interdigital phlegmon (foot rot) in cattle. " 01/01/2003 - "Seven well-controlled studies conducted under multiple management conditions demonstrated that ceftiofur, a late-generation veterinary parenteral cephalosporin, is effective for the treatment of bovine foot rot in beef and dairy cattle. "
5.	Cephalosporins (Cephalosporin Antibiotics)IBA 01/01/2003 - "Seven well-controlled studies conducted under multiple management conditions demonstrated that ceftiofur, a late-generation veterinary parenteral cephalosporin, is effective for the treatment of bovine foot rot in beef and dairy cattle. "
6.	Formaldehyde (Formol)FDA Link 09/01/1982 - "Most chemicals tested had penetration rates of less than 0.1 mm per hour and formalin, a chemical widely used for treatment of foot rot, penetrated very poorly (less than 0.02 mm per hour). " 06/17/1972 - "Corono-pedal abscessation following the excessive use of formalin as a treatment for foot-rot in sheep." 06/17/1972 - "The potential danger arising from the misuse of formalin in the treatment of foot-rot in sheep." 09/01/1989 - "A comparison was made of the efficacy of zinc sulphate and formalin footbaths in treating foot-rot of a wide range of severity in a British lowland sheep flock. " 09/01/1989 - "A comparison of the efficacy of footbaths containing formalin or zinc sulphate in treating ovine foot-rot under field conditions."
7.	IodineIBA 10/01/1989 - "A rate of 0.11 mg EDDI/kg/day was correlated with serum iodine concentrations (20 to 80 micrograms/dl) previously found to be effective in preventing foot rot in cattle. " 06/01/1981 - "Most of the herds with levels above 1,000 μg/liter were fed organic iodine above recommended levels as a prevention for foot rot. " 05/01/1976 - "Experimentally induced foot rot in feedlot cattle fed rations containing organic iodine (ethylenediamine dihydriodide) and urea."
8.	ZincIBA 09/01/1989 - "A comparison was made of the efficacy of zinc sulphate and formalin footbaths in treating foot-rot of a wide range of severity in a British lowland sheep flock. " 09/01/1989 - "A comparison of the efficacy of footbaths containing formalin or zinc sulphate in treating ovine foot-rot under field conditions."
9.	SaltsIBA 11/01/1984 - "The efficacy of an ethylenediamine dihydriodide containing salt mixture was evaluated with regard to the prevention of naturally occurring foot rot in pastured cattle. "
10.	Amoxicillin (Wymox)FDA LinkGeneric 12/01/1987 - "Efficacy of amoxicillin trihydrate for the treatment of experimentally induced foot rot in cattle." 12/01/1987 - "It was concluded that administration of amoxicillin trihydrate early in the course of acute foot rot may reduce the severity of lesions associated with foot rot in cattle."

Therapies and Procedures

1.	Pain Management 02/22/2022 - "Transdermal flunixin meglumine was approved in 2018 to treat pain related to foot-rot in cattle, leading to the question of whether it would be effective as part of a comprehensive pain management strategy for disbudding. "
2.	Therapeutics 02/01/1973 - "[Results of using the chloramphenicol drug Berlicetin-Spray in ovine foot rot therapy]."
3.	Drug Therapy (Chemotherapy) 06/01/1968 - "Parenteral chemotherapy of ovine foot-rot."
4.	Baths 08/15/1983 - "Of the chemicals commonly used in foot baths for treatment of ovine foot rot, copper sulfate was most effective, followed by zinc sulfate, then formalin. "
5.	Oral Administration 04/01/1981 - "Oral administration of zinc sulfate for control of ovine foot rot."