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Folic Acid Antagonists

Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
Also Known As:
Acid Antagonists, Folic; Antagonists, Folic Acid; Antifolates
Networked: 344 relevant articles (16 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Gangjee, Aleem: 11 articles (09/2015 - 05/2002)
2. Matherly, Larry H: 11 articles (09/2015 - 03/2007)
3. Hou, Zhanjun: 11 articles (09/2015 - 03/2007)
4. Assaraf, Yehuda G: 10 articles (10/2014 - 01/2002)
5. Zhao, Rongbao: 6 articles (02/2014 - 01/2004)
6. Goldman, I David: 6 articles (02/2014 - 01/2004)
7. McGuire, John J: 5 articles (04/2009 - 05/2002)
8. Jansen, G: 4 articles (01/2014 - 09/2000)
9. Cherian, Christina: 4 articles (11/2013 - 02/2012)
10. Jansen, Gerrit: 4 articles (12/2011 - 01/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Leukemia
3. Mesothelioma
4. Sarcoma (Soft Tissue Sarcoma)
5. Rheumatoid Arthritis

Related Drugs and Biologics

1. Methotrexate (Mexate)
2. pemetrexed (MTA)
3. Reduced Folate Carrier Protein
4. Folic Acid (Vitamin M)
5. pyrimidine
6. Aminopterin
7. purine
8. Chloroquine (Aralen)
9. 6-Mercaptopurine (Mercaptopurine)
10. Hormones

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Combination Drug Therapy (Combination Chemotherapy)
3. Heterologous Transplantation (Xenotransplantation)
4. Therapeutics