|1.||Cieśla, Joanna: 1 article (12/2015)|
|2.||Shugar, David: 1 article (12/2015)|
|3.||Wińska, Patrycja: 1 article (12/2015)|
|4.||Frączyk, Tomasz: 1 article (12/2015)|
|5.||Maj, Piotr: 1 article (12/2015)|
|6.||Zieliński, Zbigniew: 1 article (12/2015)|
|7.||Wilk, Piotr: 1 article (12/2015)|
|8.||Ruman, Tomasz: 1 article (12/2015)|
|9.||Wałajtys-Rode, Elżbieta: 1 article (12/2015)|
|10.||Jarmuła, Adam: 1 article (12/2015)|
09/01/1984 - "Those gastrointestinal tumors with higher FdUMP:dUMP ratios showed significantly greater TS inhibition. "
09/01/2002 - "The TS and DPD activity in tumor tissue was measured before and after UFT administration by the FdUMP binding assay and a catalytic assay in 38 patients, respectively. "
01/01/2001 - "Further, elevated expression of DPD in the tumor tissue results in a lack of FdUMP. "
11/01/1998 - "At the same time, the TS activity was determined with the 5-fluoro-2'-deoxyuridylate (FdUMP)-TS-binding assay in fresh-frozen specimens of these cervical cancers. "
04/01/1998 - "There was a significant correlation between the levels of FdUMP, total TS and free TS in cancer and in normal gastric mucosa, respectively. "
|2.||Colorectal Neoplasms (Colorectal Cancer)
10/15/1988 - "Colorectal tumors showed significantly greater FdUMP levels than other gastrointestinal malignancies, associated with somewhat lower free TS values. "
10/15/1988 - "Among the 30 of the 37 colorectal tumors that showed suboptimal (less than 85%) inhibition of TS, 16 (53%) showed FdUMP levels less than 75 pmol/g, 8 (27%) showed relatively high dUMP levels (over 35 nmol/g), and 16 (53%) showed poor efficiency of inhibition of TS, with the major overlap between these mechanisms of resistance being high dUMP and poor binding in 6 (20%). "
05/01/1988 - "Hemolysates were found to catalyze efficient dephosphorylation of FdUMP to yield nearly stoichiometric amounts of the corresponding deoxyribonucleoside 5-fluoro-2'-deoxyuridine (FdUrd), an antineoplastic drug showing selective cytotoxicity toward liver metastases from colorectal carcinomas. "
09/01/1995 - "We investigated the changes in the number of FdUMP binding sites in human colorectal carcinoma tissues after treatment with 5-fluorouracil derivatives and also examined the mechanisms underlying these changes. "
09/01/1995 - "The number of 5-fluoro-2'-deoxyuridine-5'-monophosphate binding sites and reduced folate pool in human colorectal carcinoma tissues: changes after tegafur and uracil treatment."
|3.||Experimental Liver Neoplasms
02/10/1977 - "Hence, the formation of FdUMP from FUra in Novikoff hepatoma cells apparently proceeds primarily via the intermediate formation of ribonucleotides. "
02/10/1977 - "N1-S1/FdUrd Novikoff hepatoma cells, which lack thymidine kinase activity, are resistant to 5-fluorouracil (FUra) as well as 5-fluorodeoxyuridine (FdUrd), suggesting that the pathway, FUra leads to FdUrd leads to FdUMP, is utilized for the conversion of FUra to FdUMP. "
02/10/1977 - "However, the inhibition of thymidylate synthetase activity, the presumed target of FdUMP, by 1 X 10(-4) M FUra in intact N1-S1 Novikoff hepatoma cells, which have significant levels of thymidine kinase activity, is completely eliminated by 5 X 10(-4) M hydroxyurea, which is a potent inhibitor of ribonucleotide reductase. "
05/01/2009 - "In the present study, we compared the ability of 5-FU and FdUMP to induce apoptosis and to influence the cell cycle progression in human colon SW620 adenocarcinoma cells in regards to their genotoxic and clastogenic activities. "
05/01/2009 - "5-Fluorouracil and its active metabolite FdUMP cause DNA damage in human SW620 colon adenocarcinoma cell line."
03/01/1999 - "TS expression was assessed by both Fluorodeoxyuridine-monophosphate (FdUMP) binding assay and cPCR in 9 human adenocarcinoma cell lines and 50 human adenocarcinoma tissues obtained by surgical resection. "
01/01/1986 - "Sequential methotrexate/5-FU: FdUMP formation and TS inhibition in a transplantable rodent colon adenocarcinoma."
04/01/1986 - "188.8.131.52), 5-fluoro 2'-deoxyuridylate (FdUMP) and 5,10-methylenetetrahydrofolate (CH2-H4PteGlu) has been examined in cytosols derived from xenografts of human colon adenocarcinomas. "
02/14/1992 - "IFN alpha treatment of HT-29 colon carcinoma cells induced a greater than two-fold increase in the intracellular levels of the active metabolite of FUra, FdUMP. "
12/15/1991 - "Quantitation of TS by Western blot analysis and biochemical FdUMP binding assay in 5-fluorouracil-resistant colon carcinoma cell lines (NCI H630R10, NCI H630R1) and a sensitive colon carcinoma cell line (NCI H630) revealed a 36- and 6-fold increase in TS in the resistant cell line as measured by the biochemical assay compared to a 39- and 10.6-fold increase as measured by densitometric analysis of the Western blot. "
01/01/1986 - "By contrast, the corresponding methyl ester of FdUMP was a tight-binding inhibitor of the enzyme from L1210, Ehrlich ascites carcinoma and CCRF-CEM cells. "
07/01/1978 - "Based on our data, a study might be warranted to determine if there is a correlation between FdUMP formation and responsiveness of colon carcinoma to 5-FU therapy."
08/01/2001 - "The levels of TS and DPD activities in nonfixed, fresh, frozen, bladder carcinoma and normal bladder specimens were determined biochemically by the FdUMP binding assay and the 5-FU degradation assay, respectively. "
|3.||Ribonucleotide Reductases (Ribonucleotide Reductase)
|7.||Folic Acid (Vitamin M)
|9.||titanium silicide (TS-1)
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Drug Therapy (Chemotherapy)