|1.||Chugani, D C: 6 articles (11/2001 - 01/2000)|
|2.||Muzik, O: 6 articles (11/2001 - 01/2000)|
|3.||Chugani, H T: 6 articles (11/2001 - 01/2000)|
|4.||Hammers, Alexander: 5 articles (01/2013 - 06/2003)|
|5.||Juhász, C: 5 articles (11/2001 - 01/2000)|
|6.||Heiss, W D: 5 articles (05/2001 - 01/2000)|
|7.||Hammers, A: 4 articles (01/2015 - 04/2001)|
|8.||Hood, Sean: 4 articles (01/2015 - 03/2002)|
|9.||Duncan, J S: 4 articles (08/2011 - 04/2001)|
|10.||Koepp, M J: 4 articles (08/2011 - 04/2001)|
11/12/1986 - "Animals treated with Ro 15-1788 still expressed lower behavioral stages when Ro 15-1788 was eliminated from the trials indicating that this compound suppresses the very process of kindling itself and not just the expression of the kindled seizures. "
11/01/2014 - "The mean onset and percentage protection against convulsion in neroli-treated mice were reduced by flumazenil. "
06/01/1991 - "Anticonvulsive efficacy of flumazenil in the electroinduced seizures in the rabbit."
10/01/2012 - "The objectives of the study were: to determine the frequency of seizures among acutely poisoned adults administered flumazenil; to identify factors associated with seizures; and to determine the mental status of subjects before and after administration of flumazenil. "
07/01/1989 - "A generalized tonic-clonic seizure was also observed in one dog of the trial with infusion of Ro 15-1788. "
08/01/1997 - "In a placebo-controlled study involving patients with mild hepatic encephalopathy, a low dose of flumazenil (0.2 mg/kg) resulted in a significant improvement in reaction time.Research"
04/01/1995 - "The infusion of 0.4-1 mg flumazenil results in a modest but rapid improvement in the EEG grading of hepatic encephalopathy and to a moderate but delayed improvement in the clinical grade of hepatic encephalopathy."
03/01/2006 - "Is flumazenil an effective treatment for hepatic encephalopathy?"
01/01/1994 - "To test this possibility, we conducted a double-blind, placebo-controlled crossover trial of the efficacy of flumazenil in cirrhotic patients in hepatic coma. "
04/01/1995 - "During 12 episodes of hepatic encephalopathy, flumazenil was administered and the EEG recording improved within 7 min (range 4-47 min; 12 out of 18 cases; 66 versus 0% for flumazenil versus placebo, respectively; P < 0.01); a modest clinical improvement in hepatic encephalopathy was observed within 83 min (range 30-340 min). "
|3.||Amnesia (Dissociative Amnesia)
08/01/1988 - "With efficacious doses of 0.2 mg-0.4 mg the Flumazenil group showed a significant improvement in collaboration and in reversing sedation and amnesia up to 30 min after the injection of the antagonist. "
09/01/1990 - "The amnesia was eliminated by flumazenil in 34 patients (72%). "
01/01/1988 - "The amnesia was totally eliminated by flumazenil. "
07/01/2012 - "On the basis of the results of flumazenil administration in this and a previous case report, we would recommend a trial dose of 0.2 mg for cases of global postoperative amnesia, repeated if the first dose seems effective."
08/01/1988 - "At the end of operations Flumazenil was i.v. injected in incremental doses up to the awakening of the patient or to a maximal dose of 1 mg. The parameters of efficacy (degree of sedation, amnesia, orientation and collaboration) and safety (vital signs, vital capacity), adverse reactions and the patient's subjective assessment were recorded up to 240 min after the injection of the trial drug. "
01/01/2002 - "Flumazenil bolus administration was associated with an improvement in Glasgow Coma Score from 7 +/- 1 to 13 +/- 1 in the nonintubatedpatients, and from 5 +/- 1 to 11 +/- in the intubated patients. "
01/01/1994 - "There are a few case reports which suggest that flumazenil can be used as a diagnostic tool in coma of unknown aetiology but no large scale studies have proved its efficacy and cost-effectiveness. "
03/01/1988 - "This study supports the introduction of Ro 15-1788 as a useful antidote in the diagnosis and the treatment of drug-induced coma."
02/01/2007 - "Coma cocktail: a role for flumazenil?"
05/01/2004 - "To our knowledge, this is the first case in children where flumazenil has been reported to reverse antihistamine-induced coma."
|5.||Respiratory Insufficiency (Respiratory Failure)
07/01/1993 - "Flumazenil may be able to improve breathing through improved consciousness, but its effects on central respiratory depression are inconsistent. "
10/01/1992 - "However, after receiving 3 mg of flumazenil, the respiratory depression improved so that the patient no longer required intubation. "
02/01/1996 - "Fourteen (25%) of the intubated patients were extubated safely while 12 patients, who had shown increased respiratory insufficiency, resumed satisfactory respiration after flumazenil injection. "
01/15/1994 - "Flumazenil for reversal of respiratory depression."
11/01/1993 - "We determined whether a large dose of flumazenil, injected alone, induces respiratory depression or alteration of psychomotor performance. "
|4.||GABA-A Receptors (GABA(A) Receptor)
|9.||gamma-Aminobutyric Acid (GABA)
|10.||PK 11195 (PK11195)
|1.||Cesarean Section (Caesarean Section)