Floxacillin (Flucloxacillin)

Antibiotic analog of CLOXACILLIN.

Also Known As:

Flucloxacillin; Fluorochloroxacillin; 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolyl)carbonyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-

Networked: 390 relevant articles (32 outcomes, 49 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pirmohamed, Munir: 7 articles (01/2019 - 06/2009)
2.	Daly, Ann K: 6 articles (01/2019 - 12/2008)
3.	Roberts, Jason A: 5 articles (03/2022 - 08/2010)
4.	Quirke, Michael: 4 articles (01/2020 - 06/2013)
5.	Wakai, Abel: 4 articles (01/2020 - 06/2013)
6.	Bue, Mats: 3 articles (07/2022 - 01/2021)
7.	Hanberg, Pelle: 3 articles (07/2022 - 01/2021)
8.	Slater, Josefine: 3 articles (07/2022 - 01/2021)
9.	Stilling, Maiken: 3 articles (07/2022 - 01/2021)
10.	Öbrink-Hansen, Kristina: 3 articles (07/2022 - 01/2021)

Related Diseases

1.	Staphylococcal Infections 04/23/1977 - "These studies showed that 18-hour diffusion sensitivity tests indicate the clinical value of treatment with flucloxacillin for staphylococcal infections of moderate severity more correctly at 37 degrees C than at 30 degrees C." 11/01/2009 - "Flucloxacillin, still the empirical choice for putative Staphylococcus aureus infections in intensive care units in the Netherlands." 08/01/1994 - "In addition, flucloxacillin (1-2 g every 4 h) could be added if there was clinical suspicion of staphylococcal infection. " 08/01/1993 - "In addition, flucloxacillin (1-2 g, every 4 h) could be added if there was clinical suspicion of staphylococcal infection (17 in each arm). " 01/01/1986 - "[Clinical evaluation of flucloxacillin in the treatment of serious staphylococcal infections in children]."
2.	Infections 08/18/2023 - "Flucloxacillin is prescribed to treat skin infections but its highly bitter taste is poorly tolerated in children. " 03/05/2023 - "According to physician experience and based on (inter)national guidelines and the severity of the infection, treatment with intravenous (IV) flucloxacillin at an initial continuous dose of 9 g/24h was started. " 08/03/2022 - "Pharmacodynamics of Flucloxacillin in a Neutropenic Murine Thigh Infection Model: A Piece of the Puzzle towards Evidence-Based Dosing." 01/01/2016 - "This difference highlights that parents of children with CF are less likely to use food to aid administration compared to those using flucloxacillin for acute infections. " 10/01/2013 - "Does routine prophylactic oral flucloxacillin reduce the incidence of post-circumcision infections?"
3.	Cellulitis 05/05/2014 - "Those who have improved substantially (defined as being afebrile, and having a lower cellulitis severity score) will be randomized at day 6 between additional 6 days of oral flucloxacillin (n = 198) or placebo (n = 198). " 05/01/2020 - "This multicentre, randomized, double-blind, placebo-controlled, non-inferiority trial enrolled adult patients hospitalized for severe cellulitis who were treated with intravenous flucloxacillin. " 05/19/2019 - "Assuming cellulitis, flucloxacillin was began. " 01/01/2019 - "He had recently received treatment for cellulitis with flucloxacillin. " 12/06/2017 - "She was commenced on flucloxacillin by the medical team for presumed cellulitis with minimal response. "
4.	Wound Infection (Wound Infections) 02/01/2017 - "Surgical complications were shoulder stiffness in 1 patient that resolved with physiotherapy and 1 superficial wound infection that was successfully treated with flucloxacillin. " 12/01/2015 - "Two patients developed a superficial wound infection, which was resolved with oral flucloxacillin. " 10/01/2013 - "When compared with no prophylactic flucloxacillin, routine prophylactic flucloxacillin does not significantly reduce the risk of post-MMC wound infection in a massive circumcision program." 10/01/2013 - "Use of routine prophylactic flucloxacillin did not significantly reduce incidence of post-MMC wound infection (odds ratio, 0.6; 95% confidence interval, 0-1.2). " 10/01/2013 - "Wound infection was present in 0.7% (5 of 646) of flucloxacillin recipients and 1.2% (8 of 645) of non-recipients (P = .4). "
5.	Endocarditis 01/01/2022 - "Bacteriophages Combined With Subtherapeutic Doses of Flucloxacillin Act Synergistically Against Staphylococcus aureus Experimental Infective Endocarditis." 07/01/2020 - "He was treated for infective endocarditis, attributed to poorly controlled AD, with intravenous Flucloxacillin. " 04/01/2015 - "We investigated whether at this temperature, mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. " 04/01/2015 - "In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro." 06/12/2023 - "After the detection of Gram-positive cocci in clusters in several blood culture sets, endocarditis was suspected, and flucloxacillin was added to the initial therapy. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	Penicillins (Penicillin)
3.	Vancomycin
4.	Clindamycin (Cleocin)
5.	Teicoplanin
6.	Methicillin (Metin)
7.	Rifampin (Rifampicin)
8.	Penicillin V (Phenoxymethylpenicillin)
9.	Cloxacillin (Tegopen)
10.	Amoxicillin (Wymox)

Related Therapies and Procedures

1.	Therapeutics
2.	Hip Replacement Arthroplasty (Total Hip Replacement)
3.	Dermatologic Surgical Procedures
4.	Intravenous Infusions
5.	Continuous Ambulatory Peritoneal Dialysis (CAPD)