|1.||Crohn Disease (Crohn's Disease)
|3.||Pathologic Constriction (Stenosis)
|5.||Rectal Fistula (Anal Fistula)
|1.||Allon, Michael: 26 articles (01/2013 - 10/2002)|
|2.||Tso, Patrick: 23 articles (12/2015 - 01/2002)|
|3.||Lok, Charmaine E: 22 articles (05/2015 - 06/2003)|
|4.||Li, Jieshou: 20 articles (01/2016 - 02/2002)|
|5.||Janicki, Joseph S: 20 articles (09/2015 - 04/2002)|
|6.||Song, Ho-Young: 20 articles (04/2014 - 03/2002)|
|7.||Asif, Arif: 19 articles (03/2015 - 11/2004)|
|8.||Shin, Ji Hoon: 19 articles (11/2014 - 12/2003)|
|9.||Brower, Gregory L: 17 articles (09/2015 - 04/2002)|
|10.||Yang, Qing: 16 articles (12/2015 - 10/2006)|
|1.||Fibrin Tissue Adhesive (Fibrin Sealant)IBA
03/01/2001 - "Fibrin glue is simple and effective treatment for all anal fistulas with excellent functional results."
12/01/2008 - "Closing the bronchial stump with an appropriate technique and supporting it with fibrin glue were considered effective in preventing bronchopleural fistula development after pulmonary resection in high-risk patients."
12/01/2002 - "Fibrin glue is a novel treatment for anal fistulas and possesses many advantages in the treatment of difficult high fistulas. "
12/20/1996 - "The successful therapy of a suboccipital cerebrospinal fluid fistula by the percutaneous introduction of fibrin glue under computed tomographic guidance is described."
01/01/2009 - "Administration of expanded ASCs (20 to 60 million cells) in combination with fibrin glue is an effective and safe treatment for complex perianal fistula and appears to achieve higher rates of healing than fibrin glue alone."
|2.||infliximab (Remicade)FDA Link
06/01/2008 - "The aims of this study were to evaluate the efficacy of combined treatment with infliximab and setons for complex perianal fistulas in CD and to define the optimal time for seton removal by anal endosonography (AE). "
12/01/2008 - "A retrospective 1-year review was undertaken of all CD patients with successfully induced remission or fistula closure with 3 infusions of infliximab. "
04/01/2015 - "This study aimed to assess the efficacy of local surgery combined with infliximab on sustained fistula closure and to identify predictive factors for response after this combined treatment. "
11/06/2004 - "In CD, infliximab induces the remission of relapses which are refractory to the conventional treatment, prevents more relapses and induces a closure of enterocutaneous and perianal fistula that do not respond to first line treatment. "
08/01/2002 - "Infliximab induces remission and heals fistulas in CD but is more costly than traditional therapies. "
|3.||Octreotide (Sandostatin)FDA LinkGeneric
05/01/1993 - "In a double blind prospective study of 19 patients with enterocutaneous fistulae, octreotide therapy was neither associated with a significant reduction in fistula losses nor an increased rate of spontaneous fistula closure."
04/01/2006 - "We report a new case of thoracic duct injury effectively treated by octreotide, leading to an early decrease in drainage and early fistula closure with minimal adverse effects. "
12/01/2000 - "We conclude that octreotide is effective in treating thoracic duct injury, leading to an early decrease in drainage and early fistula closure. "
08/01/2015 - "In these patients, octreotide was safe and effective in resolving neck chylous fistulas. "
08/01/2015 - "To evaluate the efficacy of octreotide for use in patients with postoperative chyle fistulas. "
|4.||Somatostatin (Somatotropin Release-Inhibiting Factor)IBA
02/01/2002 - "Recently, Somatostatin was shown to be highly effective in closure of refractory lymphatic fistulas. "
01/01/1994 - "Somatostatin has been shown to be very useful in the conservative treatment of digestive fistulas because of its ability to reduce output significantly and to accelerate spontaneous closure."
02/15/1991 - "Previous reports and our own results indicate that this somatostatin analogue may be very useful in the nonsurgical treatment of GI tract fistulas."
12/01/2012 - "Several randomized control trials (RCTs) have compared somatostatin and its analogues versus a control group in patients with enterocutaneous fistulas (ECF). "
05/01/2012 - "We searched Medline, EMBase, the Cochrane Central Register of Controlled Trials, as well as reference lists of textbooks and relevant articles for randomized controlled trials (RCT) comparing somatostatin analogues to control in the treatment of postoperative enterocutaneous fistulas. "
|5.||adalimumab (Humira)FDA Link
01/01/2007 - "In addition, significantly more adalimumab than placebo recipients achieved corticosteroid-free remission and had complete fistula closure. "
04/01/2008 - "Clinical trials demonstrate that adalimumab reduces the risk of CD-related hospitalization, maintains rapid complete fistula closure and is steroid-sparing, especially when administered early in the course of the disease. "
08/01/2015 - "Negative predictors included present perianal fistula (HR, 0.39; 95% CI, 0.16-0.98) and prior primary nonresponse to adalimumab (ADA; HR relative to secondary loss of response, 0.18; 95% CI, 0.04-0.76). "
10/01/2014 - "Adalimumab therapy resulted in fistula closure. "
11/01/2013 - "Fistula healing was assessed in adalimumab-randomised patients with fistula at baseline. "
|6.||Anti-Bacterial Agents (Antibiotics)IBA
01/01/2010 - "Pooling of data showed that immunoregulators and antibiotics are significantly effective for at least a 50% reduction from baseline in the number of open actively draining fistulas with relative risk (RR) of 2.57 (95% CI of 1.55-4.25, P=0.0003) in four trials and 2.05 (95% CI of 1.03-4.08, P= 0.0414) in two trials respectively. "
10/01/1990 - "From these findings, we consider that the results of one stage operation can be improved by applying pedicle muscle plombage for closure of fistula after the initial operation following treatment with effective antibiotics.(ABSTRACT TRUNCATED AT 250 WORDS)"
06/01/2015 - "The aims of this study were to investigate the pathogen spectra of fistulous tracts and their resistance to antibiotics in patients with chronic fistulas. "
09/01/2012 - "This study retrospectively assessed 24 patients with clinically suspected perianal fistula who underwent a total of 28 MR examinations after conservative treatment with antibiotics. "
01/01/1993 - "fistula, the results of studies does not favour the routine administration of antibiotics."
04/01/2013 - "Use of AFP for treatment of fistula-in-ano is safe and modestly effective in reasonable long-term (15 months) follow-up. "
07/01/2009 - "The aim of this study was to assess the efficacy of the Surgisis AFP fistula plug in a wide spectrum of patients with anorectal, rectovaginal and pouch vaginal fistulae. "
11/27/2012 - "The literature search included PubMed, EMBASE, Cochrane Library and OVID original studies on the topic of AFP compared to MAF for complex fistula-in-ano that had a deadline for publication by April 2011. "
03/01/2011 - "The aim of this study was to assess the results of the AFP procedure in a group of Danish patients with complex fistulas, and to analyse if the results were compatible with previous international findings. "
01/01/2010 - "This study aims to evaluate the cost-effectiveness of the AFP compared to the endoanal advancement flap (EAAF) as an alternative sphincter-preserving option for complex anal fistulas. "
|8.||Phenobarbital (Luminal)FDA Link
12/01/1999 - "Nine achieved clinical remission (3 luminal, 6 fistula patients). "
12/01/1999 - "Clinical remission was defined as a total CDAI < 150 (luminal patients) or >/=2+ for all parameters of the GIS (fistula patients). "
02/01/2015 - "Luminal response was assessed by the Crohn’s Disease Activity Index in four studies (three of which included fistula response) and the Harvey–Bradshaw index in two (both including fistula response), and two studies examined only the fistula response. "
09/01/1994 - "In this study, we have developed an in vivo bile and lymph fistula rat model to test the hypothesis that biliary GSH is an important luminal source of GSH. "
01/01/2014 - "Combination of intra and extra luminal negative pressure systems and ABRA is a safe and successful method to manage open abdomen with colorectal fistula."
|9.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/01/2014 - "Rectum involvement was not associated with a lower remission rate, and anti-tumor necrosis factor therapy did not increase complete fistula healing rates in simple and complex fistula. "
10/01/2008 - "With the creation of minute mesenteric lymph fistulas, the clearance of endotoxin and TNFalpha was found to be significantly high in lymph fluid exited from the intestine. "
08/01/2015 - "The availability of anti-TNF-alpha therapies has substantially changed the prospects and goals of medical treatment, and fistula healing seems to be possible in a substantial proportion of patients. "
12/08/2013 - "Because of the high rate of fistula recurrence, long term tumor necrosis factor-alpha treatment may be useful. "
01/01/2011 - "We lack clinical data about treatment other fistulas than perianal, but we suspect that effectiveness of anti-TNF alpha in this cases is lower. "
11/01/2010 - "Our results suggest that the collagen patch can be effective in the prevention and treatment of postoperative fistula after head and neck reconstruction, especially pharynx and cervical esophagus."
08/01/2002 - "The objectives of this study were to investigate the temporal response of left ventricular (LV) matrix metalloproteinase (MMP) activity and collagen volume fraction (CVF) induced by an aortocaval fistula and the role of cardiac mast cells in regulating MMP activity. "
07/01/2015 - "At 1 year, no oronasal fistulas had developed where augmentation with the acellular collagen membrane was used. "
07/01/2015 - "This report describes a series of primary palatoplasties reconstructed with a middle layer of acellular collagen membrane that aided in maintaining closure between the oral and nasal cavities without the development of an oronasal fistula. "
12/01/2014 - "Eleven patients, each of whom had previously undergone an attempt to close the fistula with a collagen button plug, underwent transvaginal repair. "
01/01/2013 - "Statistical analysis showed a significant reduction in the rate of fistula development, from 45 to 9 per cent (p < 0.01), with application of the salivary stent. "
06/01/2005 - "In this series of patients with high-flow carotid cavernous fistula associated with severe injury to the internal carotid artery, stent-assisted coil placement offered a safe and effective treatment. "
04/01/1993 - "Self-expanding metal stents proved to be safe and effective; the main drawbacks, at present, are the lack of effectiveness of these devices in case of a fistula and their high costs."
08/01/2011 - "We consider inducing granulation tissue by applying vascular plug at fistula tract in combination with covered stent placement, which is a safe and effective therapeutic option for management of intractable staple line leak after LSG."
06/01/2008 - "The use of ePTFE-covered stent placement in dysfunctional autogenous fistulas is technically feasible and, in this small series, was effective in preserving function and preventing access abandonment."
09/01/2003 - "The best results were obtained with prepucial skin graft in which the graft take was 95.3% and fistula rate was 3.2%. "
05/01/1990 - "The efficacy of preservation of the best position was demonstrated in all forms of direct collumelas, ossicular graft interposition, closure of the labyrinthine fistulas and reconstruction of the external attic wall."
12/01/1986 - "Finally, the success rate of anterior fistula repair has been dramatically improved by the addition of free periosteal grafts and cancellous bone grafts."
03/01/2004 - "The pathophysiological basis of this condition is a marked decrease or reversal of flow in the arterial segment distal to the AV fistula or AV graft, induced by the low resistance of the fistula outflow. "
12/01/2002 - "The complication rate after AV access in HIV-positive patients was significantly greater after AV graft insertion than after AV fistulas, which resulted in a higher rate of reoperation. "
08/01/2012 - "Gold-standard right heart catheterization findings have-for the first time-proven that following surgical shunt ligation of the A-V fistula, haemodynamics normalized completely in this patient. "
07/01/1992 - "Even though complete excision of the fistula represents the ideal treatment of this type of lesion, simple ligation can provide good results when the size of the fistula contraindicates embolization."
12/25/2015 - "This paper is to summarize the successful rate, complication morbidity, and the impact of ligation of the intersphinteric fistula tract (LIFT) on anal continence, and to illustrate the efficacy of LIFT procedure for the treatment of high transphinteric fistula in ano and the challenging problems existed in practice through literature review retrospectively. "
04/01/2015 - "A STS radiocephalic fistula with distal vein ligation is superior to the ETS radiocephalic fistula. "
05/01/1977 - "Renal segmental artery ligation was effective in controlling renal haemorrhage and promoting closure of the fistula in 4 patients. "
|4.||Renal Dialysis (Hemodialysis)
03/01/2013 - "To analyze the efficacy of interventions in acute dysfunctional hemodialysis fistulas, if intervention is performed immediately as recommended by European Best Practice Guidelines for Hemodialysis. "
03/01/2008 - "Vascular ultrasound has been proven to be effective in the assessment of hemodialysis fistulas providing noninvasive diagnostic work-up of vascular morphology and hemodynamics. "
12/01/2005 - "The PTD is effective for percutaneous treatment of thrombosed hemodialysis fistulas, with good short- and long-term outcomes in a U.S. "
05/01/2002 - "Our aims was to assess whether surgical intervention with the brachial artery-transposed basilic vein fistula is effective in chronic hypotensive hemodialysis patients. "
11/01/2011 - "The results of this study suggest that the AVP is a safe and effective device for the endovascular occlusion of hemodialysis fistulas in selected cases."
01/01/2008 - "As for patients with neurogenic low DC, good results were achieved in 6 of 8 patients who had had spontaneous micturition; physiologic micturition was restored in 13 out of 14 patients who had performed intermittent self catheterization and in 3 out of 5 patients with suprapubic fistula and urethral catheter. "
01/01/2008 - "6 months after the toxin injection good results were achieved in 6 out of 9 DSD patients with spontaneous micturition; physiologic micturition was restored in 5 out of 8 patients who had performed intermittent self catheterization and in 3 out of 4 patients with suprapubic fistula and urethral catheter. "
09/01/2007 - "There are significant benefits to using AVFs instead of AVGs or catheters in HD patients: greater long-term fistula patency, superior flow rates, and fewer complications. "
04/01/2008 - "Better education about the risk of adverse events with catheters and the implementation of measures aimed at reducing cannulation-related complications may help to increase fistula rates and improve patient satisfaction with their vascular access."
01/01/2001 - "We report on our experience in a retrospective study from 01/01/2000 to 30/11/2000 where we compared the effective clearance of depuration measured by the ionic dialysance of all the sessions of dialysis made on central catheters in our center, with the forecast clearance of sessions made in the same conditions of dialysis but with a non pathologic fistula. "